延邊地區(qū)朝漢族腦梗死患者同型半胱氨酸等生化指標(biāo)及頸動(dòng)脈斑塊的研究
發(fā)布時(shí)間：2018-10-14 09:34
【摘要】：目的：通過探討延邊地區(qū)朝鮮族與漢族腦梗死患者血漿同型半胱氨酸水平(Homocysteine,HCY),頸動(dòng)脈粥樣硬化斑塊及相關(guān)生化指標(biāo)的關(guān)系,為腦卒中的二級預(yù)防提供參考。 方法：對2012年6月至2014年1月在延邊大學(xué)附屬醫(yī)院神經(jīng)內(nèi)科住院治療的142例腦梗死患者的臨床資料進(jìn)行了回顧性分析計(jì),記錄每位患者的性別、民族、年齡、合并高血壓、糖尿病史情況、動(dòng)脈硬化指數(shù)(Arteriosclerosis index,AI).超敏C反應(yīng)蛋白(Hypersensitive C-reactive protein,hs-CRP).葉酸(Folic acid,FA).尿酸(Uric acid,UA).維生素B12(VitB,2)、血漿HCY和頸動(dòng)脈超聲結(jié)果,以60歲分組比較朝漢兩個(gè)民族HCY.FA.AI、UA.VitB,2指標(biāo)有無差異；根據(jù)頸動(dòng)脈超聲結(jié)果分為有斑塊組及無斑塊組,比較兩組間HCY.FA.AI.UA. VitB12.hs-CRP指標(biāo)有無差異；分析血漿HCY與FA、AI、UA、VitB12的相關(guān)性；按不同合并癥分為單純腦梗死組、腦梗死合并高血壓組、腦梗死合并糖尿病組、腦梗死合并高血壓糖尿病組,比較不同合并癥組血漿HCY水平有無差異。 結(jié)果：腦梗死患者中朝鮮族較漢族的HCY值、AI值高,FA值則是漢族較朝鮮族高,不同年齡的HCY、AI、FA值不存在統(tǒng)計(jì)學(xué)差異；有斑塊組的AI值高于無斑塊組,差異有統(tǒng)計(jì)學(xué)意義(p0.01);有斑塊組的hs-CRP值高于無斑塊組,差異有統(tǒng)計(jì)學(xué)意義(p0.01),其余指標(biāo)無統(tǒng)計(jì)學(xué)意義；HCY與FA存在負(fù)相關(guān),相關(guān)系數(shù)為-0.53,p0.01,HCY與UA存在正相關(guān)性,相關(guān)系數(shù)為0.27,p0.01,與VitB12、AI不存在相關(guān)性；不同合并癥組HCY值不完全相同,經(jīng)過兩兩比較可知單純合并高血壓組、合并高血壓糖尿病組的HCY值均高于對照組(p0.01)；單純合并糖尿病組與對照組HCY值差異不存在統(tǒng)計(jì)學(xué)差異(p0.05)；單純合并高血壓組HCY值高于合并糖尿病組,差異具有統(tǒng)計(jì)學(xué)意義(p0.01)；單純合并高血壓組與合并高血壓糖尿病組HCY值比較差異無統(tǒng)計(jì)學(xué)差異(p0.05)；合并高血壓糖尿病組HCY值高于單純合并糖尿病組(p0.01)。 結(jié)論：1.延邊地區(qū)腦梗死患者中朝鮮族與漢族的HCY、AI、FA水平有差異；2.頸動(dòng)脈斑塊組較無頸動(dòng)脈斑塊組的AI、hs-CRP水平有差異；3.HCY與FA、UA有相關(guān)性：4.腦梗死患者中合并高血壓組的較合并糖尿病組的HCY值升高。
[Abstract]:Objective: to investigate the relationship between plasma homocysteine (Homocysteine,HCY), carotid atherosclerotic plaque and related biochemical indexes in the patients with cerebral infarction in Yanbian area, so as to provide reference for the secondary prevention of stroke. Methods: the clinical data of 142 patients with cerebral infarction who were hospitalized in Department of Neurology, affiliated Hospital of Yanbian University from June 2012 to January 2014 were analyzed retrospectively. History of diabetes, arteriosclerosis index (Arteriosclerosis index,AI). Hypersensitive C-reactive protein (Hypersensitive C-reactive protein,hs-CRP). Folic acid (Folic acid,FA). Uric acid (Uric acid,UA). Vitamin B12 (VitB,2), plasma HCY and carotid artery ultrasound were compared in 60 years old with or without HCY.FA.AI,UA.VitB,2 between Korean and Han nationalities, and were divided into plaque group and non-plaque group according to the results of carotid ultrasound, and the HCY.FA.AI.UA. VitB12.hs-CRP indexes were compared between the two groups. To analyze the correlation between plasma HCY and FA,AI,UA,VitB12, according to different complications, the patients were divided into simple cerebral infarction group, cerebral infarction with hypertension group, cerebral infarction with diabetes group, cerebral infarction with hypertension diabetes group, cerebral infarction with hypertension diabetes group, cerebral infarction with hypertension diabetes mellitus group, cerebral infarction with hypertension diabetes group, cerebral infarction with hypertension diabetes group, cerebral infarction with hypertension diabetes group. To compare the plasma HCY levels in different complications. Results: in the patients with cerebral infarction, the HCY value, AI value and FA value of Korean nationality were higher than those of Han nationality, and the HCY,AI,FA value of different ages of Han nationality was higher than that of Korean nationality, the AI value of plaque group was higher than that of non-plaque group. The difference was statistically significant (p0.01), the hs-CRP value of plaque group was higher than that of non-plaque group, the difference was statistically significant (p0.01), the other indexes had no statistical significance, there was a negative correlation between HCY and FA, and the correlation coefficient was -0.53p0.01HCY and UA. The correlation coefficient was 0.27, p0.01, there was no correlation with VitB12,AI, the HCY value of the patients with different complications was not exactly the same, and the HCY values of the patients with hypertension and diabetes mellitus were higher than those of the control group (p0.01). There was no significant difference in HCY between the simple diabetes group and the control group (p0. 05), but the HCY value in the simple hypertension group was higher than that in the diabetes mellitus group, the difference was statistically significant (p0. 01). There was no significant difference in HCY between patients with hypertension and diabetes mellitus (p0. 05), and the HCY value in patients with hypertension and diabetes was higher than that in patients with hypertension and diabetes (p0. 01). Conclusion 1. There was significant difference in HCY,AI,FA level between Korean and Han in Yanbian area. The level of AI,hs-CRP in the carotid plaque group was significantly higher than that in the non-carotid plaque group, and there was a correlation between 3.HCY and FA,UA: 4. The HCY values in patients with cerebral infarction with hypertension were higher than those with diabetes.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R743.3
[Abstract]:Objective: to investigate the relationship between plasma homocysteine (Homocysteine,HCY), carotid atherosclerotic plaque and related biochemical indexes in the patients with cerebral infarction in Yanbian area, so as to provide reference for the secondary prevention of stroke. Methods: the clinical data of 142 patients with cerebral infarction who were hospitalized in Department of Neurology, affiliated Hospital of Yanbian University from June 2012 to January 2014 were analyzed retrospectively. History of diabetes, arteriosclerosis index (Arteriosclerosis index,AI). Hypersensitive C-reactive protein (Hypersensitive C-reactive protein,hs-CRP). Folic acid (Folic acid,FA). Uric acid (Uric acid,UA). Vitamin B12 (VitB,2), plasma HCY and carotid artery ultrasound were compared in 60 years old with or without HCY.FA.AI,UA.VitB,2 between Korean and Han nationalities, and were divided into plaque group and non-plaque group according to the results of carotid ultrasound, and the HCY.FA.AI.UA. VitB12.hs-CRP indexes were compared between the two groups. To analyze the correlation between plasma HCY and FA,AI,UA,VitB12, according to different complications, the patients were divided into simple cerebral infarction group, cerebral infarction with hypertension group, cerebral infarction with diabetes group, cerebral infarction with hypertension diabetes group, cerebral infarction with hypertension diabetes group, cerebral infarction with hypertension diabetes mellitus group, cerebral infarction with hypertension diabetes group, cerebral infarction with hypertension diabetes group, cerebral infarction with hypertension diabetes group. To compare the plasma HCY levels in different complications. Results: in the patients with cerebral infarction, the HCY value, AI value and FA value of Korean nationality were higher than those of Han nationality, and the HCY,AI,FA value of different ages of Han nationality was higher than that of Korean nationality, the AI value of plaque group was higher than that of non-plaque group. The difference was statistically significant (p0.01), the hs-CRP value of plaque group was higher than that of non-plaque group, the difference was statistically significant (p0.01), the other indexes had no statistical significance, there was a negative correlation between HCY and FA, and the correlation coefficient was -0.53p0.01HCY and UA. The correlation coefficient was 0.27, p0.01, there was no correlation with VitB12,AI, the HCY value of the patients with different complications was not exactly the same, and the HCY values of the patients with hypertension and diabetes mellitus were higher than those of the control group (p0.01). There was no significant difference in HCY between the simple diabetes group and the control group (p0. 05), but the HCY value in the simple hypertension group was higher than that in the diabetes mellitus group, the difference was statistically significant (p0. 01). There was no significant difference in HCY between patients with hypertension and diabetes mellitus (p0. 05), and the HCY value in patients with hypertension and diabetes was higher than that in patients with hypertension and diabetes (p0. 01). Conclusion 1. There was significant difference in HCY,AI,FA level between Korean and Han in Yanbian area. The level of AI,hs-CRP in the carotid plaque group was significantly higher than that in the non-carotid plaque group, and there was a correlation between 3.HCY and FA,UA: 4. The HCY values in patients with cerebral infarction with hypertension were higher than those with diabetes.
【學(xué)位授予單位】：延邊大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R743.3
【參考文獻(xiàn)】
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