【摘要】：目的:研究不同級別腦膜瘤的影像特征與MDM2和PTEN表達的關系,探究不同級別腦膜瘤影像表現(xiàn)的分子病理基礎,分析不同級別與MDM2,PTEN蛋白表達及關系,兩種蛋白表達與MRI征象的關系,進而揭示腫瘤發(fā)生發(fā)展中生物學行為與影像征象的關聯(lián)。方法:收集蘭州大學第二醫(yī)院2012年1月1日至2016年9月1日間經手術及病理證實的病例,術前均行MRI平掃及增強掃描,盲法記錄各病例MRI特征,查找臘塊進行MDM2、PTEN染色;所得數(shù)據應用Spss19.0統(tǒng)計軟件進行統(tǒng)計學分析。結果:不同級別腦膜瘤MRI分葉征(χ2=32.018,P0.001)、瘤腦界面(χ2=20.292,P=0.001)、瘤周水腫(χ2=8.753,P=0.013)、壞死囊變(χ2=12.619,P=0.002)、強化均勻性(χ2=13.214,P=0.001)、鄰近骨質改變(χ2=10.431,P=0.005)6項差異均有統(tǒng)計學意義(P均0.05),腦膜尾征(χ2=4.282,P=0.118)、腫瘤強化程度(χ2=5.603,P=0.061)及瘤內血管流空信號(χ2=3.617,P=0.164)3項差異無統(tǒng)計學意義(P均0.05)。腦膜瘤MDM2、PTEN蛋白免疫組化染色表達陽性,MDM2在腦膜瘤不同級別表達有差異(H=67.15,P0.001),呈正相關(r=0.889,P0.001);PTEN在腦膜瘤不同級別表達有差異(H=69.59,P0.001),呈負相關(r=-0.905,P0.001)。分葉征、瘤腦界面、瘤周水腫、壞死囊變、腫瘤強化后均勻性及鄰近骨質改變6項MRI征象與MDM2表達呈正相關,6項MRI征象與PTEN表達呈負相關。結論:不同級別腦膜瘤的MRI特征和MDM2、PTEN表達存在差異,分葉征象、瘤腦界面模糊、瘤周水腫、壞死囊變、強化不均勻及鄰近顱骨的改變等征象的鑒別意義較大,6項MRI征象與MDM2表達呈正相關,與PTEN表達呈負相關,揭示了不同級別腦膜瘤MRI征象與MDM2及PTEN表達相關性,為提高腦膜瘤分級診斷、臨床治療和預后判斷提供依據。
[Abstract]:Objective: to study the relationship between the imaging features of meningiomas of different grades and the expression of MDM2 and PTEN, to explore the molecular pathological basis of the imaging manifestations of meningiomas of different grades, and to analyze the expression and relationship between MDM2,PTEN protein and different grades of meningiomas. The relationship between the expression of two proteins and MRI signs, and the relationship between biological behavior and imaging signs in tumorigenesis and development were revealed. Methods: cases confirmed by operation and pathology from January 1, 2012 to September 1, 2016 in the second Hospital of Lanzhou University were collected. The MRI features of each case were recorded by blind method and MDM2,PTEN staining was performed before operation. The data were analyzed by Spss19.0 software. 緇撴灉:涓嶅悓綰у埆鑴戣啘鐦RI鍒嗗彾寰，

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