體素內(nèi)不相干運(yùn)動(dòng)擴(kuò)散加權(quán)成像在顱內(nèi)常見腫瘤中的應(yīng)用研究
發(fā)布時(shí)間：2018-08-31 07:32
【摘要】：第一部分體素內(nèi)不相干運(yùn)動(dòng)擴(kuò)散加權(quán)成像在良性腦膜瘤中的初步研究研究目的： 應(yīng)用多b值體素內(nèi)不相干運(yùn)動(dòng)擴(kuò)散加權(quán)磁共振成像(introvoxel incoherent motion MR imaging, IVIM MRI),探討該序列生成的單、雙指數(shù)模型在良性腦膜瘤中的應(yīng)用價(jià)值。 研究方法： 搜集臨床疑為良性腦膜瘤的患者60例,所有檢查者均簽署知情同意書,同意接受術(shù)前磁共振平掃、強(qiáng)化及多b值的IVIM序列掃描,本研究獲得本機(jī)構(gòu)倫理委員會(huì)批準(zhǔn),最終納入22例手術(shù)病理證實(shí)為良性腦膜瘤的患者。掃描序列IVIM序列由14個(gè)b值組成(自0至1000s/mm2),掃描完成后得到的IVIM序列原始數(shù)據(jù)經(jīng)后處理軟件分析,分別擬合為單、雙指數(shù)模型,并各自得到單、雙指數(shù)模型衰減曲線,同時(shí)生成對(duì)應(yīng)的參數(shù)圖(單指數(shù)擴(kuò)散系數(shù)ADC圖、雙指數(shù)擴(kuò)散系數(shù)D圖、灌注分?jǐn)?shù)f圖、灌注系數(shù)D*圖)。在各自所得不同的參數(shù)圖上結(jié)合平掃及強(qiáng)化圖像,分別測(cè)量腫瘤實(shí)質(zhì)區(qū)及正常腦白質(zhì)的單指數(shù)模型的擴(kuò)散系數(shù)ADC值以及雙指數(shù)模型的擴(kuò)散系數(shù)D值、灌注分?jǐn)?shù)f值、灌注系數(shù)D*值,然后采用配對(duì)樣本t檢驗(yàn),取a=0.05為檢驗(yàn)水準(zhǔn)進(jìn)行統(tǒng)計(jì)學(xué)分析,以P0.05為差異有統(tǒng)計(jì)學(xué)意義。 結(jié)果： 22例病人顱內(nèi)腫瘤病灶在各掃描序列均清晰顯示,在IVIM序列所生產(chǎn)的各參數(shù)圖中病變與正常腦組織分界清。腫瘤實(shí)質(zhì)區(qū)的信號(hào)衰減在單、雙指數(shù)模型衰減曲線上隨b值的增大而減小。經(jīng)所測(cè)得數(shù)據(jù)分析腫瘤實(shí)質(zhì)區(qū)平均ADC值、平均D值、平均D*值、平均f值分別為(0.87±0.13)μm2/ms、(0.79±0.10)μm2/ms、(58.68±27.52)μm2/ms、(7.68±3.59)%；正常腦白質(zhì)的平均ADC值、平均D值、平均D*值、平均f值分別為(0.74±0.06)μm2/ms、(0.69±0.04)μm2/ms、(93.43±31.64)μm2/ms、(4.48±2.39)%。經(jīng)統(tǒng)計(jì)學(xué)分析,在單指數(shù)模型中的腫瘤實(shí)質(zhì)區(qū)ADC值與正常腦白質(zhì)ADC值兩者比較差異有統(tǒng)計(jì)學(xué)意義(t=5.793,P0.05)；雙指數(shù)模型中,腫瘤實(shí)質(zhì)與正常腦白質(zhì)D、f、D*值分別進(jìn)行比較,其中腫瘤實(shí)質(zhì)的D、f值較正常腦白質(zhì)的D、f值增高(t=4.384,P0.05和t=3.349,P0.05)；在腫瘤實(shí)質(zhì)D*值中,其較正常腦白質(zhì)D*值減低(t=-3.559,P0.05),兩者比較有統(tǒng)計(jì)學(xué)意義。腫瘤實(shí)質(zhì)區(qū)單指數(shù)模型ADC值與雙指數(shù)模型D值兩者差異有統(tǒng)計(jì)學(xué)意義,且單指數(shù)模型ADC值顯著高于雙指數(shù)模型D值(t=6.492,P0.05)。 結(jié)論： 基于常規(guī)DWI序列的多b值IVIM雙指數(shù)模型不僅可以定量描述良性腦膜瘤的擴(kuò)散信息,有助于同正常腦實(shí)質(zhì)相鑒別,且較單指數(shù)模型更準(zhǔn)確；同時(shí)雙指數(shù)模型可非侵入性地獲得良性腦膜瘤的灌注信息,擴(kuò)大了灌注技術(shù)的臨床應(yīng)用范圍。 第二部分體素內(nèi)不相干運(yùn)動(dòng)擴(kuò)散加權(quán)成像在膠質(zhì)瘤中的初步研究 研究目的： 應(yīng)用多b值體素內(nèi)不相干運(yùn)動(dòng)擴(kuò)散加權(quán)磁共振成像(introvoxel incoherent motion MR imaging, IVIM MRI),探討該序列生成的單、雙指數(shù)模型在顱內(nèi)膠質(zhì)瘤中的應(yīng)用價(jià)值。 研究方法： 搜集臨床懷疑顱內(nèi)膠質(zhì)瘤的患者48例,所有檢查者均簽署知情同意書,且同意接受術(shù)前磁共振平掃、強(qiáng)化及多b值的IVIM序列掃描,研究獲得本機(jī)構(gòu)倫理委員會(huì)批準(zhǔn),最終納入25例手術(shù)病理證實(shí)為顱內(nèi)膠質(zhì)瘤的患者。IVIM序列由14個(gè)b值構(gòu)成(從0至1000s/mm2),掃描完成后所得IVIM序列原始數(shù)據(jù)經(jīng)后處理軟件處理分析,各自擬合為單、雙指數(shù)模型,并分別得到單、雙指數(shù)模型衰減曲線,同時(shí)生成相應(yīng)的參數(shù)圖(單指數(shù)擴(kuò)散系數(shù)ADC圖、雙指數(shù)擴(kuò)散系數(shù)D圖、灌注分?jǐn)?shù)f圖、灌注系數(shù)D*圖)。在各自所得不同的參數(shù)圖上結(jié)合平掃及強(qiáng)化圖像,分別測(cè)量腫瘤實(shí)質(zhì)區(qū)及正常腦白質(zhì)的單指數(shù)模型的擴(kuò)散系數(shù)ADC值以及雙指數(shù)模型中的擴(kuò)散系數(shù)D值、灌注分?jǐn)?shù)f值、灌注系數(shù)D*值,采用配對(duì)樣本t檢驗(yàn),取a=0.05為檢驗(yàn)水準(zhǔn)進(jìn)行統(tǒng)計(jì)學(xué)分析,以P0.05為差異有統(tǒng)計(jì)學(xué)意義。 結(jié)果： 25例病人顱內(nèi)膠質(zhì)瘤病灶在各掃描序列均清晰顯示,在IVIM序列所生產(chǎn)的各參數(shù)圖中病變可同正常腦組織相區(qū)分。單、雙指數(shù)模型衰減曲線上腫瘤實(shí)質(zhì)區(qū)信號(hào)強(qiáng)度隨b值的增大而衰減。膠質(zhì)瘤實(shí)質(zhì)區(qū)平均ADC值、平均D值、平均D*值、平均f值分別為(1.13±0.36)μm2/ms,(1.07±0.27)μm2/ms,(69.60±45.57)μm2/ms口(5.80±3.81)%；對(duì)側(cè)正常腦白質(zhì)平均ADC值、平均D值、平均D*值、平均f值分別為(0.77±0.08)μm2/ms,(0.72±0.06)μm2/ms、(73.27±32.22)μm2/ms和(4.09±1.58)%。單指數(shù)模型中腫瘤實(shí)質(zhì)區(qū)ADC值與正常腦白質(zhì)ADC值兩者比較差異有統(tǒng)計(jì)學(xué)意義(t=-6.165,P0.05),且腫瘤實(shí)質(zhì)區(qū)的ADC值顯著較正常腦白質(zhì)區(qū)的ADC值升高；雙指數(shù)模型中腫瘤實(shí)質(zhì)D、f、D*值分別與對(duì)側(cè)正常腦白質(zhì)D、f、D*值進(jìn)行比較,腫瘤實(shí)質(zhì)的D、f值均較正常腦白質(zhì)高(t=5.430,P0.05和t=2.312,P0.05),而腫瘤實(shí)質(zhì)區(qū)D*值與對(duì)側(cè)正常腦白質(zhì)D*值相比,兩者差異無統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論： 基于常規(guī)DWI序列的多b值IVIM雙指數(shù)模型不僅可以很好描述顱內(nèi)膠質(zhì)瘤的擴(kuò)散信息,有助于同正常腦白質(zhì)相鑒別；同時(shí)IVIM的雙指數(shù)模型可無創(chuàng)性的獲得顱內(nèi)膠質(zhì)瘤的灌注信息,大大提高了灌注技術(shù)的在顱內(nèi)膠質(zhì)瘤患者中的臨床應(yīng)用范圍。
[Abstract]:The first part is the preliminary study of intravoxel incoherent motion diffusion weighted imaging in benign meningiomas.
To investigate the application value of single and double exponential models generated by this sequence in benign meningiomas, the multi-b-value intravoxel incoherent motion-weighted magnetic resonance imaging (IVIM MRI) was used.
Research methods:
Sixty patients with clinically suspected benign meningiomas were enrolled in this study. All of them signed informed consent forms and agreed to undergo preoperative plain magnetic resonance imaging, enhanced and multi-b-value IVIM sequence scanning. This study was approved by the Ethics Committee of this institution, and eventually included 22 patients with pathologically proved benign meningiomas. The sequence of IVIM sequence was 14 B. Value composition (from 0 to 1000s/mm2), after scanning, the original IVIM sequence data were analyzed by post-processing software, and were fitted to single and double exponential models, and the attenuation curves of single and double exponential models were obtained respectively. At the same time, the corresponding parameter diagrams (single exponential diffusion coefficient ADC diagram, double exponential diffusion coefficient D diagram, perfusion fraction f diagram, perfusion coefficient D* The diffusion coefficient ADC values of the single-index model of tumor parenchyma and normal white matter, the diffusion coefficient D values of the double-index model, the perfusion fraction f values and the perfusion coefficient D* values were measured respectively on the parametric maps obtained by plain scan and contrast-enhanced images. Then the paired sample t-test was used and a=0.05 was taken as the test level for statistical analysis. The difference of P0.05 was statistically significant.
Result:
22 cases of intracranial tumor lesions were clearly displayed in each scan sequence. The lesions were clearly distinguished from normal brain tissue in the parametric maps produced by IVIM sequence. The signal attenuation of tumor parenchyma decreased with the increase of B value on the attenuation curve of single and double exponential model. The average values of D * and F * were (0.87.13) micron 2/ms, (0.79.10) micron 2/ms, (58.68.52) micron 2/ms, (7.68.59)% and (0.74.06) micron 2/ms, (0.69.04) micron 2/ms, (93.43 (31.64) micron 2/ms, (4.48.39)% respectively. The average values of ADC, D, D, and F 6550 The ADC values of tumor parenchyma and normal white matter were significantly different (t = 5.793, P 0.05); the D, f, D * values of tumor parenchyma and normal white matter were compared in double index model, in which the D, F values of tumor parenchyma were higher than those of normal white matter (t = 4.384, P 0.05 and T = 3.349, P 0.05); the D * values of tumor parenchyma were higher than those of normal white matter (t = 4.384, P 0.05 and T = 3.349, P 0.05). The D * value of normal white matter decreased (t = - 3.559, P 0.05), and the difference was statistically significant. The ADC value of single index model and double index model in tumor parenchyma was statistically significant, and the ADC value of single index model was significantly higher than that of double index model (t = 6.492, P 0.05).
Conclusion:
The multi-b-value IVIM bi-exponential model based on conventional DWI sequence can not only quantitatively describe the diffusion information of benign meningiomas, but also help to differentiate benign meningiomas from normal brain parenchyma, and is more accurate than the single-exponential model.
The second part of voxel incoherent motion diffusion weighted imaging in gliomas: a preliminary study
Research purposes:
To investigate the application value of single and double exponential models of intracranial gliomas produced by this sequence, we applied multi-b-value intravoxel incoherent motion-weighted magnetic resonance imaging (IVIM MRI).
Research methods:
A total of 48 patients with clinically suspected intracranial gliomas were enrolled in the study. All the examiners signed informed consents and agreed to undergo preoperative plain magnetic resonance imaging, enhanced and multi-b-value IVIM sequence scanning. The study was approved by the Ethics Committee of the Institute and eventually included 25 patients with pathologically confirmed intracranial gliomas. From 0 to 1000s/mm2, the original data of IVIM sequence after scanning were processed and analyzed by post-processing software. The decay curves of single-exponential and double-exponential models were fitted respectively, and the corresponding parameter diagrams (single-exponential diffusion coefficient ADC diagram, double-exponential diffusion coefficient D diagram, perfusion fraction f diagram, perfusion coefficient D* diagram) were generated. The ADC values of the single-index model of tumor parenchyma and normal white matter, the D values of perfusion fraction f and D * values of the double-index model were measured respectively from the obtained parametric maps with plain and enhanced images. The paired sample t test was used and a=0.05 was taken as the test level for statistical analysis. The P 0. 05, the difference was statistically significant.
Result:
The intracranial glioma lesions of 25 patients were clearly displayed in each scan sequence, and the lesions could be distinguished from normal brain tissues in the parametric maps produced by IVIM sequence. The signal intensity of the tumor parenchyma decreased with the increase of B value on the attenuation curve of single and double exponential model. The average ADC value, D value and D * value of the contralateral normal white matter were (1.13 +0.36) micron 2/ms, (1.07 +0.27) micron 2/ms, (69.60 +45.57) micron 2/ms, (5.80 +3.81)% and (0.77 +0.08) micron 2/ms, (0.72 +0.06) micron 2/ms, (73.27 +32.22) micron 2/ms and (4.09 +1.58)% respectively. The ADC values of tumor parenchyma were significantly higher than those of normal white matter (t = - 6.165, P 0.05), and the D, f, D * values of tumor parenchyma were significantly higher than those of normal white matter (t = 5.430, P 0.05 and T = 2.312, P 0.05). However, there was no significant difference between the D* value of tumor parenchyma and the D* value of contralateral normal white matter (P0.05).
Conclusion:
The multi-b-value IVIM bi-exponential model based on conventional DWI sequence can not only describe the diffusion information of intracranial gliomas, but also help to differentiate them from normal white matter. At the same time, the bi-exponential model of IVIM can obtain the perfusion information of intracranial gliomas noninvasively, which greatly improves the clinical application of perfusion technology in patients with intracranial gliomas. Circumference.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R739.41
本文編號(hào)：2214313
[Abstract]:The first part is the preliminary study of intravoxel incoherent motion diffusion weighted imaging in benign meningiomas.
To investigate the application value of single and double exponential models generated by this sequence in benign meningiomas, the multi-b-value intravoxel incoherent motion-weighted magnetic resonance imaging (IVIM MRI) was used.
Research methods:
Sixty patients with clinically suspected benign meningiomas were enrolled in this study. All of them signed informed consent forms and agreed to undergo preoperative plain magnetic resonance imaging, enhanced and multi-b-value IVIM sequence scanning. This study was approved by the Ethics Committee of this institution, and eventually included 22 patients with pathologically proved benign meningiomas. The sequence of IVIM sequence was 14 B. Value composition (from 0 to 1000s/mm2), after scanning, the original IVIM sequence data were analyzed by post-processing software, and were fitted to single and double exponential models, and the attenuation curves of single and double exponential models were obtained respectively. At the same time, the corresponding parameter diagrams (single exponential diffusion coefficient ADC diagram, double exponential diffusion coefficient D diagram, perfusion fraction f diagram, perfusion coefficient D* The diffusion coefficient ADC values of the single-index model of tumor parenchyma and normal white matter, the diffusion coefficient D values of the double-index model, the perfusion fraction f values and the perfusion coefficient D* values were measured respectively on the parametric maps obtained by plain scan and contrast-enhanced images. Then the paired sample t-test was used and a=0.05 was taken as the test level for statistical analysis. The difference of P0.05 was statistically significant.
Result:
22 cases of intracranial tumor lesions were clearly displayed in each scan sequence. The lesions were clearly distinguished from normal brain tissue in the parametric maps produced by IVIM sequence. The signal attenuation of tumor parenchyma decreased with the increase of B value on the attenuation curve of single and double exponential model. The average values of D * and F * were (0.87.13) micron 2/ms, (0.79.10) micron 2/ms, (58.68.52) micron 2/ms, (7.68.59)% and (0.74.06) micron 2/ms, (0.69.04) micron 2/ms, (93.43 (31.64) micron 2/ms, (4.48.39)% respectively. The average values of ADC, D, D, and F 6550 The ADC values of tumor parenchyma and normal white matter were significantly different (t = 5.793, P 0.05); the D, f, D * values of tumor parenchyma and normal white matter were compared in double index model, in which the D, F values of tumor parenchyma were higher than those of normal white matter (t = 4.384, P 0.05 and T = 3.349, P 0.05); the D * values of tumor parenchyma were higher than those of normal white matter (t = 4.384, P 0.05 and T = 3.349, P 0.05). The D * value of normal white matter decreased (t = - 3.559, P 0.05), and the difference was statistically significant. The ADC value of single index model and double index model in tumor parenchyma was statistically significant, and the ADC value of single index model was significantly higher than that of double index model (t = 6.492, P 0.05).
Conclusion:
The multi-b-value IVIM bi-exponential model based on conventional DWI sequence can not only quantitatively describe the diffusion information of benign meningiomas, but also help to differentiate benign meningiomas from normal brain parenchyma, and is more accurate than the single-exponential model.
The second part of voxel incoherent motion diffusion weighted imaging in gliomas: a preliminary study
Research purposes:
To investigate the application value of single and double exponential models of intracranial gliomas produced by this sequence, we applied multi-b-value intravoxel incoherent motion-weighted magnetic resonance imaging (IVIM MRI).
Research methods:
A total of 48 patients with clinically suspected intracranial gliomas were enrolled in the study. All the examiners signed informed consents and agreed to undergo preoperative plain magnetic resonance imaging, enhanced and multi-b-value IVIM sequence scanning. The study was approved by the Ethics Committee of the Institute and eventually included 25 patients with pathologically confirmed intracranial gliomas. From 0 to 1000s/mm2, the original data of IVIM sequence after scanning were processed and analyzed by post-processing software. The decay curves of single-exponential and double-exponential models were fitted respectively, and the corresponding parameter diagrams (single-exponential diffusion coefficient ADC diagram, double-exponential diffusion coefficient D diagram, perfusion fraction f diagram, perfusion coefficient D* diagram) were generated. The ADC values of the single-index model of tumor parenchyma and normal white matter, the D values of perfusion fraction f and D * values of the double-index model were measured respectively from the obtained parametric maps with plain and enhanced images. The paired sample t test was used and a=0.05 was taken as the test level for statistical analysis. The P 0. 05, the difference was statistically significant.
Result:
The intracranial glioma lesions of 25 patients were clearly displayed in each scan sequence, and the lesions could be distinguished from normal brain tissues in the parametric maps produced by IVIM sequence. The signal intensity of the tumor parenchyma decreased with the increase of B value on the attenuation curve of single and double exponential model. The average ADC value, D value and D * value of the contralateral normal white matter were (1.13 +0.36) micron 2/ms, (1.07 +0.27) micron 2/ms, (69.60 +45.57) micron 2/ms, (5.80 +3.81)% and (0.77 +0.08) micron 2/ms, (0.72 +0.06) micron 2/ms, (73.27 +32.22) micron 2/ms and (4.09 +1.58)% respectively. The ADC values of tumor parenchyma were significantly higher than those of normal white matter (t = - 6.165, P 0.05), and the D, f, D * values of tumor parenchyma were significantly higher than those of normal white matter (t = 5.430, P 0.05 and T = 2.312, P 0.05). However, there was no significant difference between the D* value of tumor parenchyma and the D* value of contralateral normal white matter (P0.05).
Conclusion:
The multi-b-value IVIM bi-exponential model based on conventional DWI sequence can not only describe the diffusion information of intracranial gliomas, but also help to differentiate them from normal white matter. At the same time, the bi-exponential model of IVIM can obtain the perfusion information of intracranial gliomas noninvasively, which greatly improves the clinical application of perfusion technology in patients with intracranial gliomas. Circumference.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R739.41
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