發(fā)布時(shí)間：2018-08-26 18:39

【摘要】：目的:研究不同強(qiáng)度重復(fù)經(jīng)顱磁刺激(repetitive transcranial magnetic stimulation,rTMS)對(duì)腦梗死大鼠條件性恐懼記憶的影響。方法:雄性成年SD大鼠40只,體重200~250 g,采用改良Zea longa線栓法對(duì)大鼠制作右側(cè)大腦中動(dòng)脈閉塞的腦梗死模型。建模成功的大鼠隨機(jī)分為模型組及40%(0.76 T)、60%(1.14 T)、80%(1.52 T)強(qiáng)度刺激組,每組8只,另外假手術(shù)組8只。各刺激組大鼠于建模成功后第5 d開始按照設(shè)定參數(shù)分別接受磁刺激,連續(xù)5 d,假手術(shù)組和模型組置于相同磁場(chǎng)環(huán)境,但不接受磁刺激。治療結(jié)束后,給予各組大鼠相同足底電擊(55 V,2 s),在24 h后檢測(cè)大鼠在5 min內(nèi)的僵直持續(xù)時(shí)間。結(jié)果:各刺激組大鼠在接受足底電擊24 h后的僵直持續(xù)時(shí)間均明顯高于模型組(P0.01),并且隨著刺激強(qiáng)度的增加,大鼠在24 h后的僵直持續(xù)時(shí)間也明顯增長(zhǎng)(P0.01)。結(jié)論:rTMS能促進(jìn)腦梗死大鼠記憶功能的恢復(fù),并隨著刺激強(qiáng)度的加強(qiáng),大鼠記憶能力的恢復(fù)程度亦增強(qiáng)。
[Abstract]:Aim: to study the effects of repeated transcranial magnetic stimulation (repetitive transcranial magnetic stimulation,rTMS) with different intensities on conditioned fear memory in rats with cerebral infarction. Methods: 40 adult male SD rats, weighing 200,250g, were used to establish the right middle cerebral artery occlusion model of cerebral infarction in rats by modified Zea longa thread occlusion method. The rats were randomly divided into model group and 40% (0.76 T) 60% (1.14 T) intensity stimulation group (1.52 T) with 8 rats in each group and 8 in sham operation group. The rats of each stimulation group received magnetic stimulation according to the set parameters on the 5th day after the model was successfully established. The sham operation group and the model group were placed in the same magnetic field environment for 5 days, but they did not receive the magnetic stimulation. After the treatment, the rats were given the same plantar electric shock (55 V / 2 s), after 24 h) and the duration of stiffness was detected within 5 min. Results: the duration of stiffness in each stimulation group was significantly longer than that in the model group (P0.01) after 24 h of foot shock, and with the increase of stimulation intensity, the duration of stiffness increased significantly (P0.01) after 24 h of stimulation (P0.01). Conclusion the memory function of rats with cerebral infarction can be improved with the increase of stimulation intensity, and the recovery degree of memory ability is also enhanced with the increase of stimulation intensity.
【作者單位】： 西南醫(yī)科大學(xué)附屬醫(yī)院康復(fù)科;四川省人民醫(yī)院康復(fù)科;
【基金】：四川省科技廳科研基金資助項(xiàng)目(編號(hào):2014JY0032)
【分類號(hào)】：R743.33

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