【摘要】：目的調(diào)查青海地區(qū)非致殘性缺血性腦血管事件(Non-disabling Ischemic Cerebrovascular Events,NICE)患者90天轉(zhuǎn)歸情況以及睡眠障礙的發(fā)生率,同時(shí)探討NICE患者出現(xiàn)睡眠障礙可能的危險(xiǎn)因素。方法連續(xù)納入發(fā)病7天內(nèi)住院的青海地區(qū)NICE患者,發(fā)病90±7天面對(duì)面隨訪,訪視內(nèi)容包括:完成mRS量表(modified Rankin Scale,mRS)、PSQI量表(Pittsburgh Sleep Quality Index)及ESS量表(Epworth Sleepiness Scale)。NICE睡眠障礙定義為PSQI量表評(píng)分≥11分。采用多變量logistic回歸分析明確青海地區(qū)NICE睡眠障礙的可能危險(xiǎn)因素。結(jié)果發(fā)病90±7天時(shí)成功隨訪132例,其中轉(zhuǎn)歸不良(mRS≥3分)者42例(31.8%),NICE睡眠障礙者60例(45.5%),而有42例(31.8%)存在日間嗜睡情況(ESS6分)。進(jìn)行多變量logistic回歸分析顯示,肥胖(優(yōu)勢(shì)比(odds ratio,OR)4.550,95%可信區(qū)間(95%confidence interval,95%CI),2.374~11.451,p=0.009)、轉(zhuǎn)歸不良(OR 8.545,95%CI,1.869~49.978,p=0.002)、日間嗜睡(OR 1.129,95%CI,1.069~2.978,p=0.048)、后循環(huán)病變(OR 1.223,95%CI,1.029~3.547,p=0.042)、高海拔居住(OR 1.345,95%CI,1.063~4.978,p=0.039)、合并高原紅細(xì)胞增多癥(High altitude polycythemia,HAPC)(OR 2.374,95%CI,1.679~5.263,p=0.023)是NICE 90天存在睡眠障礙的獨(dú)立危險(xiǎn)因素。進(jìn)一步篩選出高海拔居住者45例進(jìn)行分析,其中合并高粘滯血癥的高海拔患者睡眠障礙發(fā)生率(18/23)顯著高于非高粘滯血癥的高海拔患者(8/22),差異有統(tǒng)計(jì)學(xué)意義(χ~2=8.091,p=0.004)。合并HAPC的高海拔患者睡眠障礙發(fā)生率(16/22)顯著高于非HAPC的高海拔患者(10/23),差異有統(tǒng)計(jì)學(xué)意義(χ~2=3.943,p=0.047)。結(jié)論1.90天訪視時(shí)31.8%的NICE患者轉(zhuǎn)歸不良。2.較高比例的NICE患者出現(xiàn)睡眠障礙(45.5%)和日間嗜睡(31.8%)情況。3.高海拔居住、合并高原紅細(xì)胞增多癥是青海地區(qū)NICE睡眠障礙的重要危險(xiǎn)因素。
[Abstract]:Objective to investigate the outcome of 90 days and the incidence of sleep disorders in patients with non-disabled ischemic cerebrovascular events (Non-disabling Ischemic Cerebrovascular Events,NICE) in Qinghai area, and to explore the possible risk factors of sleep disorders in patients with NICE. Methods the patients with NICE in Qinghai area who were hospitalized within 7 days were followed up face to face for 90 鹵7 days. The contents of interview included: complete mRS scale (modified Rankin Scale,mRS, (Pittsburgh Sleep Quality Index) and ESS scale (Epworth Sleepiness Scale). Nice Sleep Disorder was defined as PSQI score 鈮，

本文編號(hào)：2201140