【摘要】：銅缺乏性脊髓�。╟opper deficiency myelopathy，CDM）是銅缺乏導致的神經系統(tǒng)變性疾病其病變主要累及脊髓側索后索，周圍神經和血液系統(tǒng)，，主要表現(xiàn)為雙下肢痙攣性截癱感覺性共濟失調末梢性感覺障礙和貧血粒細胞減少等，類似于維生素B12缺乏引起的亞急性聯(lián)合變性（subacute combined degeneration，SCD）的臨床表現(xiàn)磁共振（Magnetic Resonance Imaging，MRI）約半數可見脊髓后索T2高信號主要的治療方法為補銅治療該病自Schleper B于2001年首次報道之后，相關報道陸續(xù)增多，國內亦有零星報道我們將該病的病因臨床表現(xiàn)影像學及血液學特征和治療轉歸等進行總結，以提高臨床醫(yī)師對該病的認識
[Abstract]:Copper deficiency myelopathy (CDM) is a degenerative disorder of the nervous system caused by copper deficiency. Its pathological changes mainly involve the dorsal funiculus of the spinal cord, peripheral nerves and blood system. It is characterized by sensory ataxia, peripheral sensory dysfunction and anemia granulocytopenia in spastic paraplegia of both lower extremities, similar to vitamin B12. About half of the clinical manifestations of subacute combined degeneration (SCD) caused by deficiency can be seen by magnetic resonance imaging (MRI). The main treatment for T2 hyperintense signal in the posterior spinal cord is copper supplementation. Since Schleper B first reported this disease in 2001, the related reports have increased, and there are sporadic reports in China. We summarized the etiology, clinical manifestations, hematological features and treatment outcome of the disease in order to improve the understanding of clinicians.
【學位授予單位】：重慶醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R744

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