兒童全面性強(qiáng)直陣攣發(fā)作及癲癇性痙攣發(fā)作近日生物節(jié)律特征的初步研究
發(fā)布時(shí)間：2018-08-23 10:51
【摘要】：目的:探索兒童全面性強(qiáng)直陣攣發(fā)作及癲癇性痙攣發(fā)作的近日生物節(jié)律特征,以了解兩種類型癲癇發(fā)作各自的近日分布特點(diǎn),為癲癇的治療提供新的思路。方法:選擇南方醫(yī)科大學(xué)珠江醫(yī)院兒科中心腦電圖室自2015年9月到2017年02月期間所進(jìn)行的長程視頻腦電圖監(jiān)測(cè)的患兒(年齡0歲-14歲)共43例,我們共發(fā)現(xiàn)腦電圖確認(rèn)的臨床發(fā)作事件182次。其中,全面強(qiáng)直陣攣發(fā)作患兒共20例(共51次全面性強(qiáng)直陣攣發(fā)作事件);癲癇性痙攣發(fā)作患兒23例(共131次癲癇性痙攣發(fā)作事件)。我們把51次全面性強(qiáng)直陣攣發(fā)作事件及131次癲癇性痙攣發(fā)作事件作為本次研究的對(duì)象。癲癇發(fā)作類型定義根據(jù)2010年ILAE術(shù)語。我們通過分別觀察兒童全面性強(qiáng)直陣攣發(fā)作及癲癇性痙攣發(fā)作晝夜(6:00am-6:00pm為白天)分布規(guī)律、睡眠/覺醒分布規(guī)律及時(shí)間段(連續(xù)3個(gè)小時(shí)為一個(gè)時(shí)間單位將24小時(shí)分為8個(gè)時(shí)間段)分布規(guī)律,對(duì)其各自發(fā)作的近日生物節(jié)律特征進(jìn)行初步研究。同時(shí),我們還通過觀察發(fā)作晝夜分布規(guī)律、睡眠/覺醒分布規(guī)律及時(shí)間段分布規(guī)律,初步研究頭顱磁共振異常與頭顱磁共振正常的癲癇患兒全面性強(qiáng)直陣攣發(fā)作及癲癇性痙攣發(fā)作近日生物節(jié)律特征和癲癇綜合征與非癲癇綜合征患兒癲癇性痙攣發(fā)作的近日生物節(jié)律特征。我們應(yīng)用秩轉(zhuǎn)換的非參數(shù)檢驗(yàn)方法進(jìn)行統(tǒng)計(jì)分析。p0.05、0.01、0.001則認(rèn)為有統(tǒng)計(jì)學(xué)意義。結(jié)果:本研究共分析了 20例全面性強(qiáng)直陣攣發(fā)作的癲癇患兒(男17人、女3人;平均年齡4.12(0.33-13.75歲))的51次全面性強(qiáng)直陣攣發(fā)作事件。全面性強(qiáng)直陣攣發(fā)作多發(fā)于睡眠狀態(tài)(p0.05);晝夜發(fā)作分布無統(tǒng)計(jì)學(xué)意義(p0.05);全天發(fā)作高峰集中于12:00-15:00和0:00-03:00(p0.05);睡眠期發(fā)作高峰時(shí)段為12:00-15:00和0:00-03:00(p0.05),覺醒期無明顯發(fā)作高峰時(shí)間段(p0.05)。頭顱磁共振異常的患兒全面性強(qiáng)直陣攣發(fā)作多于睡眠狀態(tài)發(fā)生(p0.05);頭顱磁共振檢查正常的患兒睡眠與覺醒狀態(tài)下發(fā)作頻率無明顯差異(p0.05)。本研究還分析了 23名癲癇性痙攣患兒(其中男14人、女9人;平均年齡1.53歲(0.25-6.17歲)),的131次癲癇性痙攣發(fā)作事件。癲癇性痙攣發(fā)作多集中于白天(p0.001)和覺醒狀態(tài)(p0.01),多集中于 09:00-12:00、06:00-09:00 及15:00-18:00三個(gè)時(shí)段(p0.001)。頭顱磁共振異常的癲癇性痙攣患兒發(fā)作多集中白天(p0.001)和覺醒(p0.001),高峰時(shí)段集中于白天06:00-09:00及09:00-12:00兩個(gè)時(shí)段(p0.001)。癲癇綜合征患兒及非癲癇綜合征患兒癲癇性痙攣發(fā)作都集中于白天(p0.05)和覺醒狀態(tài)(p0.05)。但是,癲癇綜合征患兒發(fā)作高峰時(shí)段在白天09:00-12:00及15:00-18:00兩個(gè)時(shí)段(p0.05)。非癲癇綜合征患兒多發(fā)于白天06:00-09:00及09:00-12:00兩個(gè)時(shí)段(p0.01)。結(jié)論:兒童全面性強(qiáng)直陣攣發(fā)作及癲癇性痙攣發(fā)作都存在各自獨(dú)特的近日生物節(jié)律特征。掌握全面性強(qiáng)直陣攣發(fā)作及癲癇性痙攣發(fā)作的近日生物節(jié)律可為癲癇研究提供一個(gè)全新的思路,其機(jī)制有待進(jìn)一步研究。
[Abstract]:Objective: to explore the circadian rhythm characteristics of generalized tonic-clonic seizure and epileptic spasm in children in order to understand the perihelion distribution of the two types of seizures and to provide a new idea for the treatment of epilepsy. Methods: a total of 43 children (aged 0-14 years) who were monitored by electroencephalogram (EEG) from September 2015 to February 2017 in the Electroencephalogram Room of Zhujiang Hospital, Southern Medical University, were selected. We found 182 clinical seizures confirmed by EEG. There were 20 children with generalized tonic-clonic seizure (51 generalized tonic-clonic seizures) and 23 children with epileptic spasm (131 seizures). We studied 51 generalized tonic-clonic seizures and 131 epileptic spasms. Epileptic seizure type is defined according to 2010 ILAE terminology. We observed the diurnal distribution of generalized tonic-clonic seizure (6:00am-6:00pm) and epileptic spasm (6:00am-6:00pm) in children. The distribution of sleep / arousal and the distribution of different periods (24 hours were divided into 8 periods in a time unit of 3 hours in a row) were studied, and their circadian rhythms were studied. At the same time, we also observed the circadian distribution, the sleep / awakening distribution and the temporal distribution of the attack. Preliminary study on the characteristics of circadian rhythm of generalized tonic-clonic seizure and epileptic spasm in epileptic children with abnormal cranial magnetic resonance and normal cranial magnetic resonance and epileptic spasm in children with epilepsy syndrome and non-epileptic syndrome The circadian rhythms of the work. We use the nonparametric test method of rank conversion to carry on the statistical analysis. P 0.05 0. 01 0. 001 is considered to have statistical significance. Results: a total of 51 generalized tonic-clonic seizures (17 males, 3 females; mean age 4.12 (0.33-13.75 years) in 20 children with generalized tonic-clonic seizures were analyzed. The incidence of generalized tonic-clonic seizures was mostly in sleep (p0.05), the distribution of diurnal seizures was not statistically significant (p0.05), the peak of full-day seizures was 12: 00-15: 00 and 0: 00-03: 00 (p0.05), the peak periods of sleep seizures were 12: 00-15: 00 and 000-03: 00 (p0.05), and there was no obvious peak period in arousal (p0.05). The incidence of generalized tonic-clonic seizure in children with abnormal cranial magnetic resonance was more than that in sleep (p0.05), but there was no significant difference in frequency between sleep and arousal in children with normal cranial magnetic resonance examination (p0.05). This study also analysed 23 children with epileptic spasm (14 males and 9 females) with an average age of 1. 53 years (0. 25-6. 17 years old). Epileptic seizures were mainly concentrated in the daytime (p0.001) and arousal state (p0.01), and were mainly concentrated in three periods: 09: 00-12: 00 06: 00-09: 00 and 15: 00-18: 00 (p0.001). The seizures of epileptic spasm with abnormal cranial magnetic resonance were mainly concentrated in daytime (p0.001) and arousal (p0.001), and the peak periods were 0600-09: 00 and 0900-12: 00 (p0.001). Epileptic spasmodic seizures in children with epilepsy syndrome and non-epileptic syndrome were concentrated in daytime (p0.05) and arousal state (p0.05). However, the peak period of seizures in children with epilepsy syndrome was at 9: 00-12: 00 and 15: 00-18: 00 during the day (p0.05). Children with non-epileptic syndrome were found to be in two periods (p 0.01): 06: 00-09: 00 and 09: 00-12: 00 during the day. Conclusion: children with generalized tonic-clonic seizure and epileptic spasm have their own unique circadian rhythms. Mastering the circadian rhythm of generalized tonic-clonic seizure and epileptic spasm can provide a new idea for the study of epilepsy and its mechanism needs further study.
【學(xué)位授予單位】：南方醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R742.1
本文編號(hào)：2198857
[Abstract]:Objective: to explore the circadian rhythm characteristics of generalized tonic-clonic seizure and epileptic spasm in children in order to understand the perihelion distribution of the two types of seizures and to provide a new idea for the treatment of epilepsy. Methods: a total of 43 children (aged 0-14 years) who were monitored by electroencephalogram (EEG) from September 2015 to February 2017 in the Electroencephalogram Room of Zhujiang Hospital, Southern Medical University, were selected. We found 182 clinical seizures confirmed by EEG. There were 20 children with generalized tonic-clonic seizure (51 generalized tonic-clonic seizures) and 23 children with epileptic spasm (131 seizures). We studied 51 generalized tonic-clonic seizures and 131 epileptic spasms. Epileptic seizure type is defined according to 2010 ILAE terminology. We observed the diurnal distribution of generalized tonic-clonic seizure (6:00am-6:00pm) and epileptic spasm (6:00am-6:00pm) in children. The distribution of sleep / arousal and the distribution of different periods (24 hours were divided into 8 periods in a time unit of 3 hours in a row) were studied, and their circadian rhythms were studied. At the same time, we also observed the circadian distribution, the sleep / awakening distribution and the temporal distribution of the attack. Preliminary study on the characteristics of circadian rhythm of generalized tonic-clonic seizure and epileptic spasm in epileptic children with abnormal cranial magnetic resonance and normal cranial magnetic resonance and epileptic spasm in children with epilepsy syndrome and non-epileptic syndrome The circadian rhythms of the work. We use the nonparametric test method of rank conversion to carry on the statistical analysis. P 0.05 0. 01 0. 001 is considered to have statistical significance. Results: a total of 51 generalized tonic-clonic seizures (17 males, 3 females; mean age 4.12 (0.33-13.75 years) in 20 children with generalized tonic-clonic seizures were analyzed. The incidence of generalized tonic-clonic seizures was mostly in sleep (p0.05), the distribution of diurnal seizures was not statistically significant (p0.05), the peak of full-day seizures was 12: 00-15: 00 and 0: 00-03: 00 (p0.05), the peak periods of sleep seizures were 12: 00-15: 00 and 000-03: 00 (p0.05), and there was no obvious peak period in arousal (p0.05). The incidence of generalized tonic-clonic seizure in children with abnormal cranial magnetic resonance was more than that in sleep (p0.05), but there was no significant difference in frequency between sleep and arousal in children with normal cranial magnetic resonance examination (p0.05). This study also analysed 23 children with epileptic spasm (14 males and 9 females) with an average age of 1. 53 years (0. 25-6. 17 years old). Epileptic seizures were mainly concentrated in the daytime (p0.001) and arousal state (p0.01), and were mainly concentrated in three periods: 09: 00-12: 00 06: 00-09: 00 and 15: 00-18: 00 (p0.001). The seizures of epileptic spasm with abnormal cranial magnetic resonance were mainly concentrated in daytime (p0.001) and arousal (p0.001), and the peak periods were 0600-09: 00 and 0900-12: 00 (p0.001). Epileptic spasmodic seizures in children with epilepsy syndrome and non-epileptic syndrome were concentrated in daytime (p0.05) and arousal state (p0.05). However, the peak period of seizures in children with epilepsy syndrome was at 9: 00-12: 00 and 15: 00-18: 00 during the day (p0.05). Children with non-epileptic syndrome were found to be in two periods (p 0.01): 06: 00-09: 00 and 09: 00-12: 00 during the day. Conclusion: children with generalized tonic-clonic seizure and epileptic spasm have their own unique circadian rhythms. Mastering the circadian rhythm of generalized tonic-clonic seizure and epileptic spasm can provide a new idea for the study of epilepsy and its mechanism needs further study.
【學(xué)位授予單位】：南方醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R742.1
【參考文獻(xiàn)】
相關(guān)期刊論文 前5條
1 王勤華;張光磊;劉紅南;范志勇;吳信;;腎上腺糖皮質(zhì)激素節(jié)律性分泌及主要受控因素[J];動(dòng)物營養(yǎng)學(xué)報(bào);2016年02期
2 邊瑞軍;孫文環(huán);;影響癲癇患兒治療依從性因素分析及健康教育對(duì)策探討[J];實(shí)用臨床醫(yī)藥雜志;2015年14期
3 王春燕;廖萍;劉曉黎;陳文俊;何國平;;生物鐘紊亂與相關(guān)疾病關(guān)系的研究進(jìn)展[J];臨床與病理雜志;2015年04期
4 郭金虎;徐瓔;張二荃;王晗;何群;殷文璇;馮雪蓮;杜生明;;生物鐘研究進(jìn)展及重要前沿科學(xué)問題[J];中國科學(xué)基金;2014年03期
5 楊曉;許楷斯;廖衛(wèi)平;段艷鋒;;癲癇發(fā)作時(shí)辰分布特點(diǎn)與患者體質(zhì)的關(guān)系[J];河北中醫(yī);2010年09期
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