【摘要】：研究目的：研究血清hs-CRP、UA與2型糖尿病合并腦梗塞(DMCI)在頸動脈斑塊穩(wěn)定性、神經(jīng)功能缺損程度、梗塞灶面積的相關(guān)性；研究血UA水平與血清hs-CRP的相關(guān)性；研究糖尿病合并腦梗塞患者頭顱MRI特點(diǎn)。 研究方法：選擇2012年7月至2013年4月在蘭州大學(xué)第一醫(yī)院神經(jīng)內(nèi)科住院的180例首次發(fā)病的急性腦梗塞患者,其中糖尿病合并腦梗塞組90例,非糖尿病腦梗塞組90例。所有患者行頸動脈彩超檢查有無斑塊及斑塊性質(zhì),行頭顱MRI檢查明確梗塞灶的面積和部位,行NIHSS評分明確神經(jīng)功能缺損程度,并測定hs-CRP、UA、同型半胱氨酸(Hcy)、血脂、血糖、糖化血紅蛋白等含量。 研究結(jié)果：糖尿病合并腦梗塞組hs-CRP、UA含量高于非糖尿病腦梗塞組,差異有統(tǒng)計學(xué)意義；DMCI患者中,不穩(wěn)定斑塊組和穩(wěn)定斑塊組、神經(jīng)功能中重度缺損組和輕度缺損組、大面積梗塞組和小梗塞組相比,hs-CRP、UA水平差異有統(tǒng)計學(xué)意義(P0.05)。 研究結(jié)論：hs-CRP、UA水平可反映DMCI組頸動脈斑塊穩(wěn)定性、神經(jīng)功能缺損程度及腦梗塞面積大小。糖尿病合并腦梗塞主要特征是基底節(jié)區(qū)多發(fā)性腔隙性腦梗塞。腦梗塞急性期hs-CRP與UA水平呈正相關(guān)關(guān)系。
[Abstract]:Objective: to study the relationship between serum hs-CRPU UA and type 2 diabetes mellitus complicated with cerebral infarction (DMCI) in carotid plaque, nerve function defect, infarct area, serum UA level and serum hs-CRP. To study the characteristics of MRI in the head of diabetic patients with cerebral infarction. Methods: from July 2012 to April 2013, 180 patients with first onset acute cerebral infarction were selected from Department of Neurology, first Hospital of Lanzhou University, including 90 cases of diabetes complicated with cerebral infarction and 90 cases of non-diabetic cerebral infarction. All patients were examined by carotid artery color Doppler ultrasonography for plaque and plaque, head MRI was performed to determine the area and location of infarct, NIHSS score was used to determine the degree of neurological impairment, and hs-CRP UAA, homocysteine (Hcy), blood lipid, blood glucose were measured. Saccharified hemoglobin, etc. Results: the levels of hs-CRPU UA in diabetic patients with cerebral infarction were significantly higher than those in non-diabetic cerebral infarction patients. The difference was statistically significant among the unstable plaque group and stable plaque group, nerve function moderate and severe defect group and mild defect group. There was significant difference in UA level between large area infarction group and small infarction group (P0.05). Conclusion the results suggest that the level of% hs-CRPUA can reflect the stability of carotid plaque, the degree of nerve function defect and the size of cerebral infarction in DMCI group. The main characteristic of diabetes complicated with cerebral infarction is multiple lacunar infarction in basal ganglia. There was a positive correlation between hs-CRP and UA levels in acute cerebral infarction.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R587.1;R743.33

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