【摘要】：目的：探討單純性腦橋梗死的危險(xiǎn)因素、臨床特征和CISS分型。方法：回顧性分析2009年1月至2012年12月期間,在我院神經(jīng)內(nèi)科連續(xù)住院的急性腦梗死患者,單純性腦橋梗死作為病例組,前循環(huán)腦梗死為對(duì)照組,探討腦橋梗死的危險(xiǎn)因素、臨床表現(xiàn)及CISS分型。結(jié)果：?jiǎn)我蛩胤治鼋Y(jié)果顯示,與前循環(huán)梗死比較,單純性腦橋梗死組危險(xiǎn)因素中糖尿病者(53.6%vs34.1%,P=0.030)、糖化血紅蛋白(7.2±1.6vs6.6±1.7,P=0.006)、低密度脂蛋白(2.4±0.7vs2.7±0.9,P=0.003)等的差異有統(tǒng)計(jì)學(xué)意義(p0.05)；多因素logistic回歸分析結(jié)果示,糖化血紅蛋白(OR1.183,95%CI1.007-1.389,P=0.041)可能是單純性腦橋梗死的獨(dú)立危險(xiǎn)因素,持續(xù)吸煙(OR0.484,95%CI0.264-0.885,P=0.018)、低密度脂蛋白(OR0.593,95%CI0.435-0.808,P=0.001)說(shuō)明腦橋梗死患者持續(xù)吸煙、低密度脂蛋白比例低于前循環(huán)梗死者；單純性腦橋梗死及前循環(huán)梗死組臨床特征分析的結(jié)果顯示,頭暈／眩暈(46.3%vs21.6%,P=0.000)、惡心嘔吐(26.3%vs7.8%,P=0.000)、行走不穩(wěn)(29.5%vs10.2%P=0.000)、復(fù)視(10.5%vs1.2%,P=0.000)、耳鳴(6.3%vs0.3%,P=0.000)、聽力下降(6.3%vs0.6%,P=0.001)、視物模糊(7.4%vs2.1%,P=0.026)等癥狀比較的差異有統(tǒng)計(jì)學(xué)意義(p0.05)；共濟(jì)失調(diào)(38.9%vs28.1%,P=0.044)、單肢感覺障礙(7.4%vs2.4%,P=0.044)、眼外肌麻痹(8.4%vs1.5%,P=0.002)、眼球震顫(14.7%vs1.5%,P=0.000)、失語(yǔ)(1.1%vs15.6%,p=0.000)、交叉性感覺障礙(2.1%vs0,P=0.049)、周圍性面癱(2.1%vs0,P=0.049)、交叉性運(yùn)動(dòng)障礙(8.4%vs0,P=0.000)等體征比較的差異有統(tǒng)計(jì)學(xué)意義(p0.05)；納入多因素logistic回歸分析結(jié)果示,頭暈/眩暈(OR1.827,95%CI1.024-3.259,P=0.041)、惡心嘔吐(OR2.631,95%CI1.267-5.464,P=0.009)、復(fù)視(OR5.103,95%CI1.342-19.404,P=0.017)、耳鳴(OR10.512,95%CI1.119-98.714,P=0.040)、行走不穩(wěn)(OR2.547,95%CI1.328-4.884,P=0.005)、眼球震顫(OR9.368,95%CI3.251-26.991,P=0.000)和單肢感覺障礙(OR3.145,95%CI1.051-9.412)等可能與單純腦橋梗死有關(guān)；上述2組CISS分型分析結(jié)果顯示,大動(dòng)脈粥樣硬化型(25.2%vs41.3%P=0.005)、穿支動(dòng)脈疾病(65.3%vs44.0%,P=0.000)等的比較均有顯著性差異,納入多因素logistic回歸分析,結(jié)果示穿支動(dòng)脈疾病(OR2.343,95%CI1.086-5.057,P=0.030)可能與單純腦橋梗死有關(guān)。結(jié)論：?jiǎn)渭兡X橋梗死的危險(xiǎn)因素、臨床特征和CISS分型與前循環(huán)梗死不同,危險(xiǎn)因素中糖化血紅蛋白與腦橋梗死相關(guān),持續(xù)吸煙、低密度脂蛋白與前循環(huán)梗死相關(guān)；頭暈、惡心嘔吐、復(fù)視、行走不穩(wěn)、眼球震顫、耳鳴和單肢感覺障礙為單純性腦橋梗死的臨床特征；腦橋梗死的病因分型中穿支動(dòng)脈疾病更多。
[Abstract]:Objective: to investigate the risk factors, clinical features and CISS classification of simple pons infarction. Methods: from January 2009 to December 2012, the patients with acute cerebral infarction (ACI) in neurology department of our hospital were analyzed retrospectively. Simple pons infarction was used as the case group and anterior circulation infarction as control group. The risk factors of pons infarction were discussed. Clinical manifestation and CISS classification. Results: the results of univariate analysis showed that there were significant differences in the risk factors of diabetes mellitus (53.6 vs 34.1g / P 0.030), glycosylated hemoglobin (7.2 鹵1.6vs6.6 鹵1.7) and low density lipoprotein (2.4 鹵0.7vs2.7 鹵0.9 P 0.003) between patients with simple pontine infarction and those with anterior circulation infarction. The results of multivariate logistic regression analysis showed that glycosylated hemoglobin (OR1.183C95CI1.007-1.389P0.041) may be an independent risk factor for simple pontine infarction. Continuous smoking (OR0.484C95CI0.264-0.885P0. 018) and low density lipoprotein (OR0.59395CI0.435-0.808Pn0. 001) indicated that patients with pontine infarction continued to smoke. The ratio of low density lipoprotein (LDL) was lower than that of patients with anterior circulation infarction (ACI), and the clinical characteristics of patients with simple pons infarction and anterior circulation infarction (ACI) were analyzed. Dizziness / dizziness (46.3vs21.6P0.000), nausea and vomiting (26.3vs7.8), 29.5%vs10.2%P=0.000, diplopia (10.5vs1.2), tinnitus (6.3vs0.3P0.000), hearing loss (6.3vs0.65P0.000), blurred vision (7.4vs2.1m P0.026) were statistically significant (p0.05). 鍏辨祹澶辮皟(38.9%vs28.1%,P=0.044),鍗曡偄鎰熻闅滅(7.4%vs2.4%,P=0.044),鐪煎鑲岄夯鐥，

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