肌萎縮性側(cè)索硬化患者粒細胞集落刺激因子的水平
發(fā)布時間：2018-08-05 11:04
【摘要】：目的檢測肌萎縮性側(cè)索硬化(ALS)患者腦脊液(CSF)和血清中粒細胞集落刺激因子(G-CSF)、粒細胞-巨噬細胞集落刺激因子(GM-CSF)的水平變化,分析這些集落刺激因子水平與各種臨床參數(shù)的相關(guān)性。方法從65例ALS患者(ALS組)和62例非炎癥性神經(jīng)疾病(NIND)患者(NIND組)中,分別檢測腦脊液和血清標本中G-CSF、GM-CSF水平。統(tǒng)計患者的病程、ALS功能評分量表(ALSFRS-r)評分并計算疾病進展率(DPR),分別檢測腦脊液和血清標本中G-CSF、GM-CSF水平。所有標本通過ELISA酶聯(lián)免疫吸附法測量。統(tǒng)計工作由Prism軟件完成。結(jié)果與NIND組相比,ALS組患者腦脊液中G-CSF和GM-CSF的水平相對于血清中的G-CSF和GM-CSF水平顯著增加,與病程和DPR呈正相關(guān)。CSF中的G-CSF和GM-CSF與疾病進展呈正相關(guān)。結(jié)論腦脊液中G-CSF和GM-CSF水平的臨床測量有益于ALS的疾病分化和進展評估。腦脊液中的G-CSF和GM-CSF水平比血清中的可靠性更高,對疾病診斷和進展具有潛在的臨床意義。
[Abstract]:Objective to detect the levels of granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) in cerebrospinal fluid (CSF) and serum of patients with amyotrophic lateral sclerosis (ALS). The correlation between these colony stimulating factor levels and various clinical parameters was analyzed. Methods G-CSF levels in cerebrospinal fluid (CSF) and serum were measured in 65 patients with ALS (ALS group) and 62 patients with non-inflammatory neuropathy (NIND group). The disease progression rate (DPR),) was calculated and G-CSF GM-CSF levels in cerebrospinal fluid (CSF) and serum samples were measured by using the course of disease scale (ALSFRS-r) and the disease progression rate (DPR),). All specimens were measured by ELISA enzyme-linked immunosorbent assay. The statistical work is completed by Prism software. Results compared with NIND group, the levels of G-CSF and GM-CSF in CSF were significantly higher than those in serum G-CSF and GM-CSF, and were positively correlated with the course of disease and DPR. G-CSF and GM-CSF in CSF were positively correlated with disease progression. Conclusion the clinical measurement of G-CSF and GM-CSF levels in cerebrospinal fluid is helpful to evaluate the disease differentiation and progression of ALS. The levels of G-CSF and GM-CSF in cerebrospinal fluid (CSF) are more reliable than those in serum, which has potential clinical significance for disease diagnosis and progression.
【作者單位】： 天津市第一中心醫(yī)院神經(jīng)內(nèi)科;
【基金】：天津市衛(wèi)生局科技基金資助項目(編號:2015KZ022)
【分類號】：R744.8
本文編號：2165601
[Abstract]:Objective to detect the levels of granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) in cerebrospinal fluid (CSF) and serum of patients with amyotrophic lateral sclerosis (ALS). The correlation between these colony stimulating factor levels and various clinical parameters was analyzed. Methods G-CSF levels in cerebrospinal fluid (CSF) and serum were measured in 65 patients with ALS (ALS group) and 62 patients with non-inflammatory neuropathy (NIND group). The disease progression rate (DPR),) was calculated and G-CSF GM-CSF levels in cerebrospinal fluid (CSF) and serum samples were measured by using the course of disease scale (ALSFRS-r) and the disease progression rate (DPR),). All specimens were measured by ELISA enzyme-linked immunosorbent assay. The statistical work is completed by Prism software. Results compared with NIND group, the levels of G-CSF and GM-CSF in CSF were significantly higher than those in serum G-CSF and GM-CSF, and were positively correlated with the course of disease and DPR. G-CSF and GM-CSF in CSF were positively correlated with disease progression. Conclusion the clinical measurement of G-CSF and GM-CSF levels in cerebrospinal fluid is helpful to evaluate the disease differentiation and progression of ALS. The levels of G-CSF and GM-CSF in cerebrospinal fluid (CSF) are more reliable than those in serum, which has potential clinical significance for disease diagnosis and progression.
【作者單位】： 天津市第一中心醫(yī)院神經(jīng)內(nèi)科;
【基金】：天津市衛(wèi)生局科技基金資助項目(編號:2015KZ022)
【分類號】：R744.8
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