【摘要】：目的探討高敏C反應(yīng)蛋白(hs-CRP)及糖化血紅蛋白(Hb A1c)與高血壓腦出血患者頸動脈粥樣硬化斑塊的相關(guān)性。方法抽取96例高血壓腦出血患者作為研究組,根據(jù)頸總動脈內(nèi)膜厚度(IMT)將其分為重度粥樣硬化組(n=32)、輕度粥樣硬化組(n=33)、單純腦出血組(n=31),另選取31例同期體檢健康者作對照組。對比四組生化指標水平、頸動脈血管病變影響因素及不同類型斑塊患者hs-CRP及Hb A1c水平,并分析各指標與IMT的相關(guān)性。結(jié)果四組空腹血糖水平對比差異無統(tǒng)計學(xué)意義(P0.05),hs-CRP、Hb A1c、IMT、高密度脂蛋白、低密度脂蛋白、總膽固醇、甘油三酯水平對比差異均有統(tǒng)計學(xué)意義(P0.05),其中單純腦出血組總膽固醇、低密度脂蛋白、高密度脂蛋白、hs-CRP、Hb A1c水平高于對照組(P0.05);重度粥樣硬化組及輕度粥樣硬化組hs-CRP、Hb A1c、IMT、高密度脂蛋白、低密度脂蛋白、總膽固醇、甘油三酯水平均高于對照組(P0.05),且重度粥樣硬化組hs-CRP、Hb A1c最高;IMT與hs-CRP、Hb A1c呈正相關(guān);hs-CRP、Hb A1c、IMT均是頸動脈粥樣硬化斑塊形成的危險因素(P0.05);軟斑患者hs-CRP及Hb A1c水平明顯高于潰瘍斑、扁平斑、硬斑患者(P0.05)。結(jié)論 hs-CRP及Hb A1c均是導(dǎo)致高血壓腦出血患者發(fā)生頸動脈粥樣硬化斑塊的危險因素。
[Abstract]:Objective to investigate the relationship between Gao Min C-reactive protein (hs-CRP) and glycosylated hemoglobin (HbA1c) and carotid atherosclerotic plaque in patients with hypertensive intracerebral hemorrhage. Methods 96 patients with hypertensive intracerebral hemorrhage were selected as study group and divided into severe atherosclerosis group (n = 32), mild atherosclerosis group (n = 33) and intracerebral hemorrhage group (n = 31) according to carotid intima thickness (IMT). The levels of hs-CRP and HbA1c in patients with different types of plaque were compared, and the correlation between the indexes and IMT was analyzed. Results there was no significant difference in fasting blood glucose levels among the four groups (P0.05). There were significant differences in the levels of hs-CRPnHbA1cCIMT, HDL, LDL-C, TC and TG (P0.05), among which the total cholesterol in the intracerebral hemorrhage group was higher than that in the control group. The levels of HbA1c in low density lipoprotein (LDL) and high density lipoprotein (HDL-C) were higher than those in control group (P0.05), while in severe atherosclerosis group and mild atherosclerotic group, hs-CRPnHbA1cT, high density lipoprotein, low density lipoprotein, total cholesterol, high density lipoprotein, low density lipoprotein, total cholesterol, The levels of triglyceride were significantly higher than those of the control group (P0.05), and the levels of hs-CRP1c HbA1c in severe atherosclerosis were positively correlated with hs-CRP1c HbA1c (P0.05), the levels of hs-CRP and HB A1c in patients with soft plaque were significantly higher than those in ulceral plaque, flat plaque. Patients with hard spot (P0.05). Conclusion hs-CRP and HB A 1c are risk factors for carotid atherosclerotic plaque in patients with hypertensive intracerebral hemorrhage.
【作者單位】： 荊州市第二人民醫(yī)院神經(jīng)內(nèi)科;荊州市第二人民醫(yī)院神經(jīng)外科;荊州市第二人民醫(yī)院B超科;
【基金】：湖北省自然科學(xué)基金資助項目(2013CFB080)
【分類號】：R743.34

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