發(fā)布時(shí)間：2018-07-28 14:25

【摘要】：目的：通過(guò)研究頸內(nèi)動(dòng)脈粥樣硬化和腦梗死患者血清中NGAL和sLox-1的表達(dá)變化及其阿托伐他汀的干預(yù)作用，探討NGAL和sLOX-1在頸內(nèi)動(dòng)脈粥樣硬化形成以及腦梗死發(fā)病過(guò)程中的作用。 方法：篩選2012年3月至2013年9月在我院神經(jīng)內(nèi)科就診的缺血性腦卒中以及頸內(nèi)動(dòng)脈粥樣硬化患者各80例，分別隨機(jī)分為阿托伐他汀常規(guī)治療組（20mg，，n=40）和強(qiáng)化治療組（40mg，n=40），并收集所有入選患者臨床資料。分別在阿托伐他汀治療開(kāi)始前、治療12周和24周時(shí)采集各患者血清，采用酶聯(lián)免疫吸附法測(cè)定患者血清中NGAL和sLox-1的濃度，并同時(shí)運(yùn)用彩超測(cè)定患者治療前和治療后24周頸內(nèi)動(dòng)脈內(nèi)膜中層厚度。收集實(shí)驗(yàn)數(shù)據(jù)，應(yīng)用統(tǒng)計(jì)軟件SPSS17.0進(jìn)行統(tǒng)計(jì)分析，設(shè)定檢驗(yàn)水準(zhǔn)α=0.05。 結(jié)果：1.腦梗死患者血清中NGAL和sLox-1的濃度較動(dòng)脈粥樣硬化患者高，差異具有統(tǒng)計(jì)學(xué)意義（P 0.05）； 2.阿托伐他汀干預(yù)后血清NGAL和sLox-1的濃度明顯下降，差異均有統(tǒng)計(jì)學(xué)意義（P 0.05）； 3.阿托伐他汀強(qiáng)化治療比常規(guī)治療能更顯著降低血清中NGAL和sLox-1的濃度，差異有統(tǒng)計(jì)學(xué)意義； 4.阿托伐他汀干預(yù)24周后頸內(nèi)動(dòng)脈內(nèi)膜中層厚度下降，差異具有統(tǒng)計(jì)學(xué)意義。 結(jié)論：1、NGAL和sLox-1參與頸部動(dòng)脈粥樣硬化及斑塊的形成。 2、阿托伐他汀強(qiáng)化治療可以有效降低NGAL及sLox-1的水平，且可以有逆轉(zhuǎn)內(nèi)膜厚度的功能。
[Abstract]:Objective: to study the expression of NGAL and sLox-1 in the serum of patients with internal carotid atherosclerosis and cerebral infarction and the intervention of Atto vastatin to explore the role of NGAL and sLOX-1 in the formation of carotid atherosclerosis and the pathogenesis of cerebral infarction. Methods: from March 2012 to September 2013, 80 patients with ischemic stroke and 80 patients with internal carotid atherosclerosis were selected. The patients were randomly divided into two groups: Atto vastatin group (20 mg / L) and intensive treatment group (40 mg / L). The clinical data of all patients were collected. The serum levels of NGAL and sLox-1 were measured by enzyme-linked immunosorbent assay (Elisa) after 12 and 24 weeks of Atto vastatin treatment, respectively. The intima-media thickness of internal carotid artery was measured by color Doppler ultrasound before and 24 weeks after treatment. Collect experimental data, use statistical software SPSS17.0 for statistical analysis, set the test level 偽 0.05. The result is 1: 1. The concentrations of NGAL and sLox-1 in patients with cerebral infarction were significantly higher than those in patients with atherosclerosis (P 0.05). The concentration of serum NGAL and sLox-1 decreased significantly after the intervention of Atto vastatin, and the difference was statistically significant (P 0.05). The concentration of NGAL and sLox-1 in serum was significantly decreased by intensive treatment of Atto vastatin compared with conventional treatment, and the difference was statistically significant. 4. The intima-media thickness of internal carotid artery decreased after 24 weeks of intervention by Atto vastatin, and the difference was statistically significant. Conclusion 1% NGAL and sLox-1 are involved in the formation of carotid atherosclerosis and plaque. 2. Intensive treatment of Atto vastatin can effectively reduce the levels of NGAL and sLox-1, and can reverse the thickness of intima.
【學(xué)位授予單位】：南華大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R743.3

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