【摘要】：目的:探討血清抗幽門螺旋桿菌抗體(HP-Ig G)和抗AQP4抗體在多發(fā)性硬化(MS)、視神經(jīng)脊髓炎(NMO)中的相關(guān)性。方法:對33例MS患者、7例NMO患者和35例健康體檢者采用間接酶聯(lián)免疫吸附法(ELISA法)檢測血清中抗HP的Ig G抗體,采用細胞間接免疫熒光法(CBA)檢測血清標本抗AQP4抗體;分析MS、NMO患者中HP-Ig G及抗AQP4抗體的陽性率,并對比抗AQP4抗體陽性與抗AQP4抗體陰性患者間HP-Ig G陽性率的差別。結(jié)果:MS組、NMO組和正常對照組血清中抗血清HP-IgG抗體陽性率分別為69.70%、85.71%、42.86%,差別有統(tǒng)計學意義(P0.05),其中MS組、NMO組與正常對照組血清中抗HP-Ig G抗體陽性率差別均有統(tǒng)計學意義(P0.05);但MS組與NMO組血清中抗HP-Ig G抗體陽性率差別無統(tǒng)計學意義(P0.05)。MS組、NMO組和正常對照組血清中抗AQP4抗體陽性率分別為4.2%、85.71%、0%,差別有統(tǒng)計學意義(P0.05)。MS組和NMO患者組中抗AQP4抗體陽性患者與抗AQP4抗體陰性患者抗HP-IgG抗體陽性率分別為72.73%、79.31%,差別無統(tǒng)計學意義(P0.05)。結(jié)論:HP感染是引起MS及NMO疾病發(fā)生的危險因素,而與MS及NMO患者是否含有抗AQP4抗體無關(guān)。
[Abstract]:Objective: To investigate the correlation between serum anti Helicobacter pylori antibody (HP-Ig G) and anti AQP4 antibody in multiple sclerosis (MS) and optic neuromyelitis (NMO). Methods: 33 cases of MS, 7 NMO patients and 35 healthy subjects were detected by indirect enzyme linked immunosorbent assay (ELISA method) to detect Ig G antibody in serum, and indirect immunofluorescence was used. The positive rate of HP-Ig G and anti AQP4 antibody in MS and NMO patients was analyzed by CBA, and the difference of HP-Ig G positive rate between anti AQP4 antibody positive and anti AQP4 negative patients was compared. The results showed that the positive rate of anti serum antibody in the serum of MS group and normal control group was 69.70%, 85.71%, 42.86%, respectively. There were statistical significance (P0.05), in group MS, the positive rate of anti HP-Ig G antibody in serum of NMO group and normal control group was statistically significant (P0.05), but there was no significant difference in the positive rate of anti HP-Ig G antibody between group MS and NMO group (P0.05), and the positive rate of anti G antibody in serum was 4.2%, 85.71%, 0%, respectively. The difference was statistically significant (P0.05) in group.MS and NMO patients, the positive rate of anti HP-IgG antibody in anti AQP4 antibody positive patients and anti AQP4 negative patients was 72.73% and 79.31% respectively, the difference was not statistically significant (P0.05). Conclusion: HP infection was a risk factor for the occurrence of MS and NMO diseases, but not with MS and NMO patients.
【作者單位】： 南昌大學研究生院;江西省人民醫(yī)院神經(jīng)內(nèi)科;
【基金】：江西省科技廳科研院所基礎(chǔ)設(shè)施配套項目(20123BBA13050) 國家臨床重點�？平ㄔO(shè)項目(衛(wèi)辦醫(yī)政函[2012]649號)
【分類號】：R744.5

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