顱咽管瘤的復(fù)發(fā)與其病理類型及年齡的關(guān)系研究
發(fā)布時(shí)間：2018-07-26 20:34
【摘要】：第一部分顱咽管瘤的復(fù)發(fā)與腫瘤的病理類型的關(guān)系研究 目的：通過(guò)對(duì)顱咽管瘤病理類型資料與腫瘤復(fù)發(fā)的數(shù)據(jù)進(jìn)行分析,明確顱咽管瘤的復(fù)發(fā)與腫瘤的病理類型之間有無(wú)關(guān)系,有助于顱咽管瘤患者術(shù)后的預(yù)后分析和后續(xù)治療方案的選擇。 方法：調(diào)查自2000年1月至2012年12月間于武漢協(xié)和醫(yī)院神經(jīng)外科接受顱咽管瘤手術(shù)的患者共230例,從中選取有明確病理分型且未失訪的病例共59例,收集其臨床資料,隨訪調(diào)查患者的復(fù)發(fā)情況。其中造釉細(xì)胞型顱咽管瘤35例,鱗狀乳頭型患者24例。年齡分布為2歲～66歲,36例為男性患者,23例為女性患者。利用SPSS19.0統(tǒng)計(jì)工具分析調(diào)查和隨訪所得的數(shù)據(jù),用卡方檢驗(yàn)比較兩種病例類型的復(fù)發(fā)率有無(wú)顯著差異。使用SPSS軟件通過(guò)壽命表法和Kaplan-Meier法繪制累積無(wú)復(fù)發(fā)生存曲線和累積復(fù)發(fā)曲線,P0.05認(rèn)為具有統(tǒng)計(jì)學(xué)意義。 結(jié)果：對(duì)符合標(biāo)準(zhǔn)的59例顱咽管瘤患者進(jìn)行隨訪,造釉細(xì)胞型35例,其中13例復(fù)發(fā)(復(fù)發(fā)率37.1%),鱗狀乳頭型24例,其中3例復(fù)發(fā)(復(fù)發(fā)率12.5%)。對(duì)顱咽管瘤的病理類型和復(fù)發(fā)數(shù)進(jìn)行卡方檢驗(yàn),結(jié)果提示不同病理類型的顱咽管瘤在復(fù)發(fā)率上的差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。以病理類型為單因素,使用SPSS軟件對(duì)59例顱咽管瘤患者復(fù)發(fā)所需時(shí)間(以月計(jì)算)進(jìn)行分析,通過(guò)壽命量表法和Kaplan-Meier法分別得出累計(jì)無(wú)復(fù)發(fā)生存曲線和累積復(fù)發(fā)曲線,提示造釉細(xì)胞型顱咽管瘤的復(fù)發(fā)率要高于鱗狀乳頭型顱咽管瘤,二者的累積復(fù)發(fā)率有顯著差異(P0.05) 結(jié)論：不同病理類型的顱咽管瘤患者復(fù)發(fā)率存在較大差異,腫瘤的病理類型是影響咽管瘤患者術(shù)后復(fù)發(fā)的重要因素。 第二部分顱咽管瘤的復(fù)發(fā)與患者年齡的關(guān)系研究 目的：收集接受手術(shù)的顱咽管瘤患者的年齡資料,結(jié)合隨訪所得的患者復(fù)發(fā)數(shù)據(jù),分析顱咽管瘤的復(fù)發(fā)與患者年齡有無(wú)關(guān)聯(lián)。 方法：調(diào)查自2000年1月至2012年12月間武漢協(xié)和醫(yī)院神經(jīng)外科收治的接受顱咽管瘤手術(shù)的患者共230例,除外因聯(lián)系方式缺失、原有聯(lián)系方式失效等原因失訪者,最終篩選出符合標(biāo)準(zhǔn)的病例共97例。其中63例男性患者,34例女性患者。將研究對(duì)象按0-20歲,21～60歲分為少兒組和成人組。對(duì)研究對(duì)象進(jìn)行追蹤調(diào)查,收集其術(shù)后有無(wú)復(fù)發(fā)及復(fù)發(fā)所需的時(shí)間(以月計(jì)算)。利用SPSS19.0統(tǒng)計(jì)工具分析調(diào)查和隨訪所得的數(shù)據(jù),用卡方檢驗(yàn)比較各年齡段患者的復(fù)發(fā)率有無(wú)顯著差異。使用SPSS軟件通過(guò)壽命量表法和Kaplan-Meier法分別繪制累計(jì)無(wú)復(fù)發(fā)生存曲線和累積復(fù)發(fā)曲線,P0.05認(rèn)為具有統(tǒng)計(jì)學(xué)意義。 結(jié)果：對(duì)符合標(biāo)準(zhǔn)的97例顱咽管瘤患者進(jìn)行隨訪,0-20歲的患者共40例,其中14例復(fù)發(fā),20～60歲的患者共57例,其中9例復(fù)發(fā)。對(duì)顱咽管瘤按照年齡段的復(fù)發(fā)率進(jìn)行卡方檢驗(yàn)(表1-1),結(jié)果為不同年齡的顱咽管瘤在復(fù)發(fā)率上的差異不具有統(tǒng)計(jì)學(xué)意義(P0.05)。使用SPSS軟件分析比較兩個(gè)年齡段的顱咽管瘤患者的累積無(wú)復(fù)發(fā)生存曲線和累積復(fù)發(fā)曲線,可見(jiàn)結(jié)果無(wú)顯著差異(P0.05)。 結(jié)論：雖然不同年齡的顱咽管瘤患者復(fù)發(fā)率雖無(wú)明顯差異,但是少兒的顱咽管瘤復(fù)發(fā)率相比成人有著更高的趨勢(shì),年齡也可能是影響咽管瘤患者術(shù)后復(fù)發(fā)的潛在因素。 第三部分顱咽管瘤的病理類型與患者年齡的關(guān)系研究 目的：研究顱咽管瘤的病理類型和患者的年齡有無(wú)關(guān)系。 方法：自2000年1月至2012年12月間武漢協(xié)和醫(yī)院神經(jīng)外科收治的接受顱咽管瘤手術(shù)的患者共230例,篩選出具有明確病理分型的病例共68例。其中38例男性患者,30例女性患者。將研究對(duì)象按0-20歲,21～60歲分為少兒組和成人組,分別調(diào)查各組中造釉細(xì)胞型和鱗狀乳頭型顱咽管瘤的病例數(shù)。利用SPSS19.0統(tǒng)計(jì)工具分析調(diào)查和隨訪所得的數(shù)據(jù),用卡方檢驗(yàn)比較各年齡段造釉細(xì)胞型和鱗狀乳頭型顱咽管瘤的比例有無(wú)顯著差異。使用SPSS軟件對(duì)病理類型和年齡進(jìn)行單因素方差分析,P0.05認(rèn)為具有統(tǒng)計(jì)學(xué)意義。 結(jié)果：在符合標(biāo)準(zhǔn)的68例顱咽管瘤患者中,0-20歲的患者共31例,其中27例為造釉細(xì)胞型,4例為鱗狀乳頭型,20～60歲的患者共37例,其中11例為造釉細(xì)胞型,26例為鱗狀乳頭型。對(duì)顱咽管瘤的病理類型按照年齡段進(jìn)行卡方檢驗(yàn),結(jié)果為不同年齡的顱咽管瘤的病理類型差異有統(tǒng)計(jì)學(xué)意義(P0.05)。 結(jié)論：少兒和成人顱咽管瘤患者好發(fā)的病理類型存在較大差異,造釉細(xì)胞型多發(fā)于兒童,鱗狀乳頭型多發(fā)于成人。
[Abstract]:Part one the relationship between recurrence of craniopharyngioma and pathological types of tumor
Objective: to analyze the pathological type of craniopharyngioma and the data of tumor recurrence, and to identify the relationship between the recurrence of craniopharyngioma and the pathological type of the tumor. It is helpful for the prognosis analysis and the choice of follow-up treatment plan for the patients with craniopharyngioma after operation.
Methods: a total of 230 patients who underwent craniopharyngioma surgery in Department of Neurosurgery of Wuhan Union Hospital from January 2000 to December 2012 were investigated, and 59 cases with clear pathological and non missing cases were selected, and their clinical data were collected and followed up to investigate the recurrence of the patients. 35 cases of enamel type craniopharyngioma, squamous papilloma There were 24 cases. The age distribution was from 2 to 66 years, 36 were male and 23 was female. The data of investigation and follow-up were analyzed by SPSS19.0 statistical tool. There was no significant difference in the recurrence rate of two case types by chi square test. The cumulative non recurrent survival curve was plotted by SPSS software and Kaplan-Meier method. And the cumulative recurrence curve, P 0.05, was statistically significant.
Results: 59 cases of craniopharyngioma were followed up. There were 35 cases of enamel cell type, of which 13 cases had relapse (recurrence rate 37.1%) and 24 cases of squamous papillary type, of which 3 cases relapsed (recurrence rate 12.5%). The pathological type and recurrence number of craniopharyngioma were checked by chi square test, and the results suggested the difference in the recurrence rate of craniopharyngioma with different pathological types. The difference was statistically significant (P0.05). With the pathological type as a single factor, the time required for the recurrence of 59 cases of craniopharyngioma was analyzed using the SPSS software. The cumulative recurrence free survival curve and cumulative recurrence curve were obtained by the life scale and Kaplan-Meier method, suggesting that the relapse rate of the enamel type craniopharyngioma was higher. In the papillary craniopharyngioma, there was a significant difference in the cumulative recurrence rate between the two groups (P0.05).
Conclusion: the recurrence rate of craniopharyngioma patients with different pathological types is quite different. The pathological type of tumor is an important factor affecting postoperative recurrence of patients with pharyngioma.
The relationship between recurrence of craniopharyngioma and age of second patients
Objective: to collect the age data of craniopharyngioma patients undergoing surgery, and to analyze the recurrence of patients with the recurrence of craniopharyngioma, and to analyze the correlation between the recurrence of craniopharyngioma and the age of the patients.
Methods: a total of 230 patients received craniopharyngioma surgery in Department of Neurosurgery of Wuhan Union Hospital from January 2000 to December 2012 were investigated. In addition, 97 cases were selected, including 63 cases of male and 34 female patients. The subjects were divided into the children's group and the adult group at the age of 0-20 and 21~60. The subjects were tracked and the time required for the recurrence and recurrence after the operation was collected. The SPSS19.0 statistical tools were used to analyze the data of the investigation and follow-up, and there was no significant difference in the recurrence rate of the patients in all ages with the chi square test. The use of SPSS soft. The cumulative recurrence free survival curve and cumulative recurrence curve were plotted by life span scale and Kaplan-Meier respectively, and P0.05 showed statistical significance.
Results: 97 cases of craniopharyngioma were followed up. There were 40 cases of 0-20 year old patients, of which 14 had relapsed and 57 were 20~60 years old, of which 9 had recurrences. The recurrence rate of craniopharyngioma at different ages was not statistically significant. Significance (P0.05). The cumulative recurrence survival curve and cumulative recurrence curve of craniopharyngioma patients in two ages were analyzed using SPSS software, and there was no significant difference between the results (P0.05).
Conclusion: Although there is no significant difference in the recurrence rate of patients with craniopharyngiomas at different ages, the recurrence rate of children's craniopharyngioma is higher than that in adults, and age may also be a potential factor affecting postoperative recurrence of pharyngioma.
The relationship between pathological types of third craniopharyngiomas and age of patients
Objective: To study the relationship between the pathological types of craniopharyngioma and the age of the patients.
Methods: from January 2000 to December 2012, 230 cases of craniopharyngioma underwent surgery in Department of Neurosurgery, Wuhan Union Hospital, and 68 cases with clear pathological types were selected, including 38 male and 30 female patients. The subjects were divided into children group and adult group at the age of 0-20 and 21~60 years old, respectively. The number of cases of middle enamel type and squamous papillary craniopharyngioma were analyzed by SPSS19.0 statistical tools, and there was no significant difference in the proportion of the age segments of the enamel and squamous papillary craniopharyngiomas with the chi square test. A single factor variance analysis was performed on the type and age of the disease by using the SPSS software, P 0.05 think it is statistically significant.
Results: of the 68 cases of craniopharyngioma, 31 cases were 0-20 years old, of which 27 were apioid, 4 were squamous papillary, 20~60 years old in 37 cases, of which 11 were enamel type and 26 was squamous papillary. The pathological type of craniopharyngioma was checked by age group, and the result was different age. The pathological types of craniopharyngioma were statistically different (P0.05).
Conclusion: the pathological types of craniopharyngioma in children and adults are quite different.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2014
【分類號(hào)】：R739.4
本文編號(hào)：2147216
[Abstract]:Part one the relationship between recurrence of craniopharyngioma and pathological types of tumor
Objective: to analyze the pathological type of craniopharyngioma and the data of tumor recurrence, and to identify the relationship between the recurrence of craniopharyngioma and the pathological type of the tumor. It is helpful for the prognosis analysis and the choice of follow-up treatment plan for the patients with craniopharyngioma after operation.
Methods: a total of 230 patients who underwent craniopharyngioma surgery in Department of Neurosurgery of Wuhan Union Hospital from January 2000 to December 2012 were investigated, and 59 cases with clear pathological and non missing cases were selected, and their clinical data were collected and followed up to investigate the recurrence of the patients. 35 cases of enamel type craniopharyngioma, squamous papilloma There were 24 cases. The age distribution was from 2 to 66 years, 36 were male and 23 was female. The data of investigation and follow-up were analyzed by SPSS19.0 statistical tool. There was no significant difference in the recurrence rate of two case types by chi square test. The cumulative non recurrent survival curve was plotted by SPSS software and Kaplan-Meier method. And the cumulative recurrence curve, P 0.05, was statistically significant.
Results: 59 cases of craniopharyngioma were followed up. There were 35 cases of enamel cell type, of which 13 cases had relapse (recurrence rate 37.1%) and 24 cases of squamous papillary type, of which 3 cases relapsed (recurrence rate 12.5%). The pathological type and recurrence number of craniopharyngioma were checked by chi square test, and the results suggested the difference in the recurrence rate of craniopharyngioma with different pathological types. The difference was statistically significant (P0.05). With the pathological type as a single factor, the time required for the recurrence of 59 cases of craniopharyngioma was analyzed using the SPSS software. The cumulative recurrence free survival curve and cumulative recurrence curve were obtained by the life scale and Kaplan-Meier method, suggesting that the relapse rate of the enamel type craniopharyngioma was higher. In the papillary craniopharyngioma, there was a significant difference in the cumulative recurrence rate between the two groups (P0.05).
Conclusion: the recurrence rate of craniopharyngioma patients with different pathological types is quite different. The pathological type of tumor is an important factor affecting postoperative recurrence of patients with pharyngioma.
The relationship between recurrence of craniopharyngioma and age of second patients
Objective: to collect the age data of craniopharyngioma patients undergoing surgery, and to analyze the recurrence of patients with the recurrence of craniopharyngioma, and to analyze the correlation between the recurrence of craniopharyngioma and the age of the patients.
Methods: a total of 230 patients received craniopharyngioma surgery in Department of Neurosurgery of Wuhan Union Hospital from January 2000 to December 2012 were investigated. In addition, 97 cases were selected, including 63 cases of male and 34 female patients. The subjects were divided into the children's group and the adult group at the age of 0-20 and 21~60. The subjects were tracked and the time required for the recurrence and recurrence after the operation was collected. The SPSS19.0 statistical tools were used to analyze the data of the investigation and follow-up, and there was no significant difference in the recurrence rate of the patients in all ages with the chi square test. The use of SPSS soft. The cumulative recurrence free survival curve and cumulative recurrence curve were plotted by life span scale and Kaplan-Meier respectively, and P0.05 showed statistical significance.
Results: 97 cases of craniopharyngioma were followed up. There were 40 cases of 0-20 year old patients, of which 14 had relapsed and 57 were 20~60 years old, of which 9 had recurrences. The recurrence rate of craniopharyngioma at different ages was not statistically significant. Significance (P0.05). The cumulative recurrence survival curve and cumulative recurrence curve of craniopharyngioma patients in two ages were analyzed using SPSS software, and there was no significant difference between the results (P0.05).
Conclusion: Although there is no significant difference in the recurrence rate of patients with craniopharyngiomas at different ages, the recurrence rate of children's craniopharyngioma is higher than that in adults, and age may also be a potential factor affecting postoperative recurrence of pharyngioma.
The relationship between pathological types of third craniopharyngiomas and age of patients
Objective: To study the relationship between the pathological types of craniopharyngioma and the age of the patients.
Methods: from January 2000 to December 2012, 230 cases of craniopharyngioma underwent surgery in Department of Neurosurgery, Wuhan Union Hospital, and 68 cases with clear pathological types were selected, including 38 male and 30 female patients. The subjects were divided into children group and adult group at the age of 0-20 and 21~60 years old, respectively. The number of cases of middle enamel type and squamous papillary craniopharyngioma were analyzed by SPSS19.0 statistical tools, and there was no significant difference in the proportion of the age segments of the enamel and squamous papillary craniopharyngiomas with the chi square test. A single factor variance analysis was performed on the type and age of the disease by using the SPSS software, P 0.05 think it is statistically significant.
Results: of the 68 cases of craniopharyngioma, 31 cases were 0-20 years old, of which 27 were apioid, 4 were squamous papillary, 20~60 years old in 37 cases, of which 11 were enamel type and 26 was squamous papillary. The pathological type of craniopharyngioma was checked by age group, and the result was different age. The pathological types of craniopharyngioma were statistically different (P0.05).
Conclusion: the pathological types of craniopharyngioma in children and adults are quite different.
【學(xué)位授予單位】：華中科技大學(xué)
【學(xué)位級(jí)別】：博士
【學(xué)位授予年份】：2014
【分類號(hào)】：R739.4
【參考文獻(xiàn)】
相關(guān)期刊論文 前2條
1 潘軍,漆松濤,鄧永鍵,丁彥青,彭林,李曉強(qiáng);顱咽管瘤增殖細(xì)胞核抗原表達(dá)與腫瘤復(fù)發(fā)的關(guān)系[J];第一軍醫(yī)大學(xué)學(xué)報(bào);2002年04期
2 李宗平;游潮;譚學(xué)書(shū);劉平;黃思慶;徐建國(guó);;顱咽管瘤的臨床特征與預(yù)后的分析[J];華西醫(yī)學(xué);2008年03期
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