【摘要】：帕金森病是以運(yùn)動(dòng)障礙為主要表現(xiàn)的神經(jīng)退行性疾病,藥物治療以緩解運(yùn)動(dòng)癥狀為核心。外科治療始于立體定向技術(shù)的應(yīng)用,以核團(tuán)毀損術(shù)與腦深部電刺激術(shù)為主要術(shù)式。帕金森病外科治療可以部分改善臨床癥狀,但不能延緩疾病進(jìn)展。目前基于神經(jīng)營養(yǎng)因子及神經(jīng)遞質(zhì)替代的基因治療方法正在研究中,它可能是帕金森病治療較有前景的治療方案。該文就帕金森病腦深部電刺激術(shù)及基因治療的研究進(jìn)展予以綜述。
[Abstract]:Parkinson's disease is a neurodegenerative disease characterized by dyskinesia. Drug therapy focuses on relieving motor symptoms. Surgical treatment began with the application of stereotactic technique. The main methods were nucleus lesion and deep brain stimulation. Surgical treatment of Parkinson's disease can partly improve the clinical symptoms, but can not delay the progress of the disease. At present, gene therapy based on neurotrophic factor and neurotransmitter substitution is being studied, which may be a promising treatment for Parkinson's disease. This article reviews the progress of deep brain electrical stimulation and gene therapy in Parkinson's disease.
【作者單位】： 同濟(jì)大學(xué)附屬同濟(jì)醫(yī)院神經(jīng)內(nèi)科;
【基金】：國家自然科學(xué)基金項(xiàng)目(81371403)
【分類號】：R742.5

【共引文獻(xiàn)】

相關(guān)期刊論文 前7條

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2 Meyer Mylène;Montel Sébastien;Colnat-Coulbois Sophie;Lerond Jér，

本文編號：2146552