本文選題：急性腦梗死 + 認(rèn)知功能障礙��； 參考：《江西醫(yī)藥》2018年04期

【摘要】：目的分析老年急性腦梗死認(rèn)知功能障礙的特點(diǎn)及其與血漿腦利鈉肽前體(pro-BNP)和C反應(yīng)蛋白(CRP)的關(guān)系。方法選擇醫(yī)院2015年8月-2017年8月期間收治的老年急性腦梗死患者40例為觀察組,同期老年健康體檢者40例為對(duì)照組。比較兩組的臨床資料,血漿pro-BNP和CRP水平;采用卒中量表(NIHSS)和認(rèn)知評(píng)價(jià)量表(Mo CA)評(píng)價(jià)老年急性腦梗死患者認(rèn)知功能及神經(jīng)功能,Pearson相關(guān)性分析法分析老年急性腦梗死患者認(rèn)知功能與血漿pro-BNP和CRP的關(guān)系。結(jié)果觀察組NIHSS評(píng)分(30.2±8.6)分,顯著高于對(duì)照組;Mo CA評(píng)分(13.1±3.2)分,顯著低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。觀察組血漿pro-BNP和CRP水平分別為(509.4±102.6)pg/ml與(22.8±6.5)mg/L,顯著高于對(duì)照組相應(yīng)指標(biāo),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。不同程度腦梗死患者的血漿pro-BNP和CRP水平上比較有顯著差異;不同程度神經(jīng)損傷的急性腦梗死患者在血漿pro-BNP和CRP水平上比較有顯著差異;觀察組中,認(rèn)知功能障礙患者血漿pro-BNP和CRP水平分別為(572.9±43.7)pg/ml與(26.4±4.2)mg/L,顯著高于無(wú)認(rèn)知功能障礙患者相應(yīng)指標(biāo),差異有統(tǒng)計(jì)學(xué)意義(P0.05)。老年急性腦梗死血漿pro-BNP和CRP水平與Mo CA呈負(fù)相關(guān),與NIHSS呈正相關(guān)。結(jié)論老年急性腦梗死患者容易發(fā)生認(rèn)知功能障礙,急性期血漿pro-BNP和CRP水平顯著升高的患者認(rèn)知功能障礙更為嚴(yán)重,預(yù)后差。
[Abstract]:Objective to analyze the characteristics of cognitive impairment in elderly patients with acute cerebral infarction and its relationship with plasma pro-BNP and C-reactive protein (CRP). Methods from August 2015 to August 2017, 40 elderly patients with acute cerebral infarction were selected as observation group and 40 cases as control group. Compared the clinical data of the two groups, plasma pro-BNP and CRP levels; The relationship between cognitive function and plasma pro-BNP and CRP in elderly patients with acute cerebral infarction was analyzed by means of stroke scale (NIHSS) and cognitive evaluation scale (MoCA). Results the NIHSS score of the observation group (30.2 鹵8.6) was significantly higher than that of the control group (13.1 鹵3.2), which was significantly lower than that of the control group (P0.05). The plasma pro-BNP and CRP levels in the observation group were (509.4 鹵102.6) pg/ml and (22.8 鹵6.5) mg / L, respectively, which were significantly higher than those in the control group (P0.05). There were significant differences in plasma pro-BNP and CRP levels in patients with different degrees of cerebral infarction, and significant differences in plasma pro-BNP and CRP levels in patients with acute cerebral infarction with different degrees of nerve injury. The plasma pro-BNP and CRP levels in patients with cognitive impairment were (572.9 鹵43.7) pg/ml and (26.4 鹵4.2) mg / L, respectively, which were significantly higher than those in patients without cognitive impairment (P0.05). Plasma pro-BNP and CRP levels in elderly patients with acute cerebral infarction were negatively correlated with Mo CA and positively correlated with NIHSS. Conclusion elderly patients with acute cerebral infarction are prone to cognitive dysfunction, and the patients with significantly increased plasma pro-BNP and CRP levels in the acute phase are more serious in cognitive dysfunction and poor prognosis.
【作者單位】： 上海市第六人民醫(yī)院金山分院ICU
【分類號(hào)】：R743.33

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