發(fā)布時(shí)間：2018-07-07 15:29

  本文選題：胼胝體膝部梗死 + 聽(tīng)覺(jué)事件相關(guān)電位P��； 參考：《中國(guó)老年學(xué)雜志》2017年10期

【摘要】：目的探討胼胝體膝部梗死患者聽(tīng)覺(jué)事件相關(guān)電位P300的特征及其在患者診斷中的應(yīng)用價(jià)值。方法選擇胼胝體膝部梗死患者17例(病例組)及同期健康檢查人群17例(對(duì)照組)為研究對(duì)象。采用美國(guó)Nicolet Spirit腦誘發(fā)電位儀,進(jìn)行聽(tīng)覺(jué)事件相關(guān)電位P300檢測(cè),分析比較病例組與對(duì)照組之間P300潛伏期及波幅有無(wú)差異(P0.05)。結(jié)果病例組P300潛伏期顯著長(zhǎng)于對(duì)照組(t=4.85,P0.05);病例組波幅顯著低于對(duì)照組(t=8.79,P0.05);病例組簡(jiǎn)易精神狀態(tài)檢查(MMSE)量表評(píng)分與波幅明顯負(fù)相關(guān)性(r=-0.61,P0.05),但與潛伏期無(wú)明顯相關(guān)性(r=-0.07,P=0.78)。以潛伏期為指標(biāo),診斷胼胝體膝部梗死的敏感性為94.12%,特異性為76.47%,ROC曲線(xiàn)下面積為0.83;以波幅為參考指標(biāo)診斷診斷胼胝體膝部梗死的敏感性為100%,特異性為94.22%,ROC曲線(xiàn)下面積為0.98。結(jié)論胼胝體膝部梗死患者聽(tīng)覺(jué)事件相關(guān)電位P300的潛伏期延長(zhǎng)和MMSE評(píng)分與波幅明顯負(fù)相關(guān)性,可作為電生理診斷的參考指標(biāo)。
[Abstract]:Objective to investigate the characteristics of auditory event-related potential (P300) in patients with genu infarction of corpus callosum and its diagnostic value. Methods 17 cases of genu infarction of corpus callosum (case group) and 17 cases of health examination (control group) were selected. The auditory event-related potential (P300) was detected by Nicolet Spirit brain evoked potentiometer in the United States of America. The latency and amplitude of P300 were compared between the case group and the control group (P0.05). Results the latency of P300 in the case group was significantly longer than that in the control group (P 0.05), the amplitude of the wave in the case group was significantly lower than that in the control group (t = 8.79 P 0.05), and the score of the MMSE scale in the case group was negatively correlated with the amplitude of the wave (P 0.05), but there was no significant correlation between the amplitude and the latency (r 0. 07 P 0. 78). The sensitivity and specificity for the diagnosis of genu infarction of corpus callosum were 94.12, 76.47 and 0.83 respectively, and the sensitivity and specificity of the ROC curve were 100 and 0.98, respectively, using the amplitude of wave as the reference index for the diagnosis of the genu infarction of corpus callosum. Conclusion the latency of auditory event-related potential P300 in patients with genu infarction of corpus callosum is prolonged, and the MMSE score is negatively correlated with the amplitude of the wave, which can be used as a reference index for the diagnosis of electrophysiology.
【作者單位】： 天津市西青醫(yī)院神經(jīng)內(nèi)科;天津醫(yī)科大學(xué)總醫(yī)院神經(jīng)內(nèi)科;
【分類(lèi)號(hào)】：R743.33

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