發(fā)布時間：2018-07-03 02:01

  本文選題：顱內(nèi)海綿狀血管瘤(CCM) + RhoA��； 參考：《中南大學》2014年碩士論文

【摘要】：目的：檢測RhoA在顱內(nèi)海綿狀血管瘤組織和正常腦血管組織中的表達。 材料和方法：運用免疫組化SP法檢測顱內(nèi)海綿狀血管組織和正常腦血管組織中石蠟切片RhoA的表達情況,通過RT-PCR法檢測顱內(nèi)海綿狀血管瘤患者RhoA基因表達。 結(jié)果：免疫組化SP法檢測在正常腦組織血管中和顱內(nèi)海綿狀血管瘤組織中RhoA表達存在差異性,合并出血與未合并出血海綿狀血管瘤組織中存在差異性,單個病變直徑≥2.5cm組和單個病變直徑2.5cm組存在差異性。病變位于幕上或幕下則無差異性。RhoA mRNA在正常腦組織血管和CCM組織中表達有差異性,病變部位血管的破裂出血可使RhoA基因表達較病變部位未出血的RhoA基因表達升高。RhoA基因的表達在單個病變直徑大于等于2.5cm中較單個病變直徑小于2.5cm中要升高。 結(jié)論：RhoA在顱內(nèi)海綿狀血管瘤中明顯比在正常腦組織血管中表達高,RhoA的表達上調(diào)是顱內(nèi)海綿狀血管瘤的一個特征,且隨著病灶的直徑增加,以及伴有出血,RhoA的表達還會增高。
[Abstract]:Objective: to detect the expression of RhoA in intracranial cavernous hemangioma and normal cerebral vascular tissue. Materials and methods: immunohistochemical SP method was used to detect the expression of RhoA gene in intracranial cavernous vascular tissue and normal cerebral vascular tissue, and RT-PCR was used to detect the expression of RhoA gene in intracranial cavernous hemangioma. Results: immunohistochemical SP method was used to detect the difference of RhoA expression in the blood vessels of normal brain tissues and intracranial cavernous hemangioma tissues, and the difference between complicated hemorrhage and non-hemorrhage cavernous hemangioma tissues. There were differences between single lesion diameter 鈮，

本文編號：2091882