本文選題：腦梗死 + 危險(xiǎn)因素��； 參考：《新鄉(xiāng)醫(yī)學(xué)院》2017年碩士論文

【摘要】：背景隨著社會(huì)快節(jié)奏的發(fā)展,日常不良的生活方式也更多地走進(jìn)了人們的生活,也因此造成了一些軀體疾患危害著人類的健康,如腦血管病,這種傳統(tǒng)意識(shí)中的老年病在危害老年人群身體健康的同時(shí)也漸漸地地走入了青年人群的生活。青年人群在社會(huì)中占據(jù)著重要的地位,是社會(huì)發(fā)展的中間力量,只有加強(qiáng)對(duì)青年腦血管病的認(rèn)識(shí)及重視,了解其危險(xiǎn)因素所在,才能及早的從根源上預(yù)防和治療青年腦梗死,促動(dòng)社會(huì)的進(jìn)步。目的探究青年腦梗死的危險(xiǎn)因素,為青年缺血性腦血管病的預(yù)防以及治療提供有力的理論基礎(chǔ)。方法采用病例對(duì)照研究。選取2015年1月-2016年1月于我院神經(jīng)內(nèi)科住院確診為青年腦梗死的患者122例作為實(shí)驗(yàn)組,同期門(mén)診體檢的118例健康青年為對(duì)照組。收集研究對(duì)象的一般資料、入院血液學(xué)指標(biāo),分別選用單因素、多因素logistic回歸分析、敏感性分析的方法以探討青年腦梗死的危險(xiǎn)因素特征。結(jié)果1、單因素分析顯示:青年梗死組與健康青年組之間吸煙、高血壓病、糖尿病、高膽固醇、高同型半胱氨酸、高尿酸、高胱抑素C、高堿性磷酸酶、高白細(xì)胞計(jì)數(shù)、高中性粒細(xì)胞百分比、高紅細(xì)胞分布寬度之間的差異有統(tǒng)計(jì)學(xué)意義(P0.05)。2、多因素回歸分析顯示:青年梗死組與健康青年組之間高血壓病(OR=6.819,95%C I:3.339-13.928)、高尿酸(OR=2.888,95%CI:1.211-6.888)、高胱抑素C(OR=4.978,95%CI:1.405-17.630)、高堿性磷酸酶(OR=4.343,95%CI:1.897-9.941)、高中性粒細(xì)胞百分比(OR=9.204,95%CI:1.771-47.823)、高紅細(xì)胞分布寬度(O R=11.816,95%CI:2.227-62.700)的差異有統(tǒng)計(jì)學(xué)意義(P0.05)。3、敏感性分析顯示:各因素ROC曲線下面積的排序?yàn)?高血壓高堿性磷酸酶高中性粒細(xì)胞百分比高胱抑素C高尿酸高紅細(xì)胞分布寬度。結(jié)論1、吸煙、高血壓病、糖尿病、高膽固醇、高同型半胱氨酸、高尿酸、高胱抑素C、高堿性磷酸酶、高白細(xì)胞計(jì)數(shù)、高中性粒細(xì)胞百分比、高紅細(xì)胞分布寬度均是青年腦梗死的危險(xiǎn)因素。2、高血壓病、高尿酸、高胱抑素C、高堿性磷酸酶、高中性粒細(xì)胞百分比、高紅細(xì)胞分布寬度為青年腦梗死的獨(dú)立性危險(xiǎn)因素。3、各獨(dú)立性危險(xiǎn)因素可以對(duì)疾病的發(fā)生作簡(jiǎn)單的預(yù)測(cè),且預(yù)測(cè)價(jià)值排序?yàn)?高血壓高堿性磷酸酶高中性粒細(xì)胞百分比高胱抑素C高尿酸高紅細(xì)胞分布寬度。
[Abstract]:Background with the rapid development of the society, the bad daily life style has come into people's life more often, thus causing some body diseases to endanger the human health, such as cerebrovascular disease. This kind of old age disease of traditional consciousness not only endangers the health of the old people, but also gradually steps into the life of the young people. Young people occupy an important position in the society and are the intermediate force of social development. Only by strengthening the understanding and attention of young cerebrovascular disease and understanding its risk factors, can we prevent and treat young cerebral infarction from the root causes as soon as possible. Stimulate the progress of society. Objective to explore the risk factors of cerebral infarction in young people and to provide a theoretical basis for the prevention and treatment of ischemic cerebrovascular disease in young people. Methods A case-control study was conducted. From January 2015 to January 2016, 122 young patients with cerebral infarction were selected as experimental group and 118 healthy young people in outpatient examination as control group. The general data of the subjects were collected, and the admission hematologic indexes were collected. The single factor, multivariate logistic regression analysis and sensitivity analysis were used to study the risk factors of cerebral infarction in young people. Results 1. Univariate analysis showed that smoking, hypertension, diabetes, high cholesterol, high homocysteine, high uric acid, high cystatin C, high alkaline phosphatase, high white blood cell count, high alkaline phosphatase, high white blood cell count, hypertension, diabetes mellitus, hypercholesterolemia, hyperhomocysteine, high alkaline phosphatase, and high leukocyte count were found between the young infarction group and the Percentage of high neutrophils, There were significant differences in the distribution width of high red blood cells (P0.05). The multivariate regression analysis showed that hypertension was found between the young infarction group and the healthy youth group (ORO 6.819 ~ 95CI: 3.339-13.928), high uric acid (OR2.8888-95CIW 1.211-6.888), high cystatin C (OR4.97895 CIW 1.405-17.630), high alkaline phosphatase (OR4.34395 CIW 1.897-9.941), high neutrophil granulocyte size (1.897-9.941), high neutrophilic acid (OR 2.888C95 CI: 1.405-17.630), high alkaline phosphatase (OR4.343C95), high neutrophil fine granulocyte. The percentage of cells (OR9.20495 CI: 1.771-47.823) and the width of high erythrocyte distribution (O RV 11.816 ~ 95CI: 2.227-62.700) were significantly different (P0.05). Sensitivity analysis showed that the order of the area under the ROC curve was: high blood pressure, high alkaline phosphatase, high neutrophil percentage, high cystatin C High uric acid, high erythrocyte distribution width. Conclusion 1 smoking, hypertension, diabetes, high cholesterol, high homocysteine, high uric acid, high cystatin C, high alkaline phosphatase, high white blood cell count, high neutrophil percentage; Hypererythrocyte distribution width was the risk factor of cerebral infarction in young adults. Hypertension, hyperuric acid, cystatin C, high alkaline phosphatase, high neutrophil percentage. The distribution width of high erythrocyte is the independent risk factor of young cerebral infarction. The independent risk factors can be used to predict the occurrence of the disease. The order of predictive value was as follows: the percentage of high neutrophils in hypertension and alkaline phosphatase was high cystatin C high uric acid high erythrocyte distribution width.
【學(xué)位授予單位】：新鄉(xiāng)醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R743.33

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