發(fā)布時間：2018-06-26 04:04

  本文選題：西洛他唑 + 阿司匹林��； 參考：《中國臨床藥理學雜志》2017年03期

【摘要】：目的觀察西洛他唑片聯(lián)合阿司匹林片和氯吡格雷片對老年腦血管疾病神經(jīng)介入后抗血栓作用的臨床療效及安全性。方法將39例進行腦血管疾病神經(jīng)介入術患者隨機分為對照組11例和試驗組28例。對照組予以口服阿司匹林300 mg qd+口服氯吡格雷75 mg qd。試驗組在對照組治療的基礎上,予以口服西洛他唑200 mg qd。2組患者均從術前1周服藥至術后6個月。比較2組患者的臨床療效、血小板聚集率及血流動力學指標,以及藥物不良反應的發(fā)生情況。結果治療后,試驗組和對照組的總有效率分別為85.71%(24/28例)和54.55%(6/11例),差異有統(tǒng)計學意義(P0.05)。治療后,試驗組和對照組的血小板聚集率分別為(44.57±8.44)%,(56.83±11.46)%;全血黏度切變率分別為(2.92±1.09)%,(3.96±1.32)%;血漿黏度分別為(1.20±0.32),(1.51±0.43)m Pa·s;相對血液黏度切變率分別為(2.18±0.28)%,(2.50±0.41)%;血細胞比容分別為(0.38±0.06)%,(0.48±0.06)%;纖維蛋白原分別為(2.83±1.04),(3.29±1.26)g·L~(-1),差異均有統(tǒng)計學意義(P0.05)。2組患者發(fā)生的藥物不良反應以頭痛和胃腸道反應為主,且試驗組和對照組的藥物不良反應發(fā)生率分別為21.43%和27.27%,差異無統(tǒng)計學意義(P0.05)。結論西洛他唑片聯(lián)合阿司匹林片和氯吡格雷片對老年腦血管疾病神經(jīng)介入后抗血栓作用顯著,且不增加藥物不良反應的發(fā)生率。
[Abstract]:Objective to observe the clinical efficacy and safety of cilostazol tablets combined with aspirin tablets and clopidogrel tablets in the treatment of senile cerebrovascular diseases after neurovascular intervention. Methods 39 patients with cerebrovascular disease were randomly divided into control group (n = 11) and experimental group (n = 28). The control group was treated with aspirin 300 mg QD and clopidogrel 75 mg QD. On the basis of the treatment in the control group, the patients in the 200mg qd.2 group were treated with cilostazol from 1 week before operation to 6 months after operation. The clinical efficacy, platelet aggregation rate, hemodynamic indexes and adverse drug reactions were compared between the two groups. Results after treatment, the total effective rates of the experimental group and the control group were 85.71% (24 / 28 cases) and 54.55% (6 / 11 cases), respectively. The difference was statistically significant (P0.05). After treatment, 璇曢獙緇勫拰瀵圭収緇勭殑琛，

本文編號：2069000