本文選題：糖化白蛋白 + 輕型缺血性卒中��； 參考：《青島大學(xué)》2017年碩士論文

【摘要】：目的:探討糖化白蛋白水平與急性輕型缺血性卒中的相關(guān)性,進(jìn)一步分析糖化白蛋白水平在不同病因分型的急性輕型缺血性卒中患者的差異,為不同病因分型急性輕型缺血性卒中的診治提供理論依據(jù)。方法:選擇2014年12月至2016年12月在我院神經(jīng)內(nèi)科住院的急性輕型缺血性卒中患者145例,對(duì)每例患者進(jìn)行腦血管病危險(xiǎn)因素篩查,并檢測(cè)患者的血清糖化白蛋白指標(biāo),再根據(jù)患者顱腦MRI、MRA或CTA檢查進(jìn)行CISS卒中病因分型,選出大動(dòng)脈粥樣硬化型(LAA)輕型卒中患者84例和穿支動(dòng)脈疾病型(PAD)輕型卒中患者61例,選擇同期在我院健康體檢中心查體的無(wú)卒中人群130例作為正常對(duì)照,比較急性輕型缺血性卒中組和無(wú)卒中對(duì)照組的血管危險(xiǎn)因素、空腹血糖和糖化白蛋白水平;再進(jìn)一步比較分析年齡、性別、高血壓、糖尿病、高脂血癥、空腹血糖和糖化白蛋白水平在LAA組和PAD組的差異是否有統(tǒng)計(jì)學(xué)意義。結(jié)果:與無(wú)卒中對(duì)照組比較,病例組中高血壓、糖尿病、高脂血癥、吸煙史、空腹血糖和糖化白蛋白水平明顯高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(均P0.05)。亞組分析發(fā)現(xiàn),糖尿病亞組中,輕型卒中組患者糖化白蛋白水平顯著高于無(wú)卒中對(duì)照組[(21.3±4.7)%(17.2±1.9)%,P0.01];在非糖尿病亞組中也得出相似結(jié)論。多因素Logistic回歸分析顯示,在校正常見(jiàn)危險(xiǎn)因素后,無(wú)論在總?cè)巳�、糖尿病亞組還是非糖尿病亞組中,糖化白蛋白水平增高均為急性輕型缺血性卒中患者的獨(dú)立危險(xiǎn)因素(P0.05)。LAA組和PAD組兩組比較發(fā)現(xiàn),年齡、性別、高脂血癥常見(jiàn)危險(xiǎn)因素的差異有統(tǒng)計(jì)學(xué)意義(P0.05),而空腹血糖、糖化白蛋白水平在兩組種的差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:本研究提示糖化白蛋白與急性輕型缺血性卒中的發(fā)生顯著相關(guān),糖化白蛋白水平增高是急性輕型缺血性卒中的獨(dú)立危險(xiǎn)因素;糖化白蛋白水平在LAA組和PAD組的差異無(wú)顯著統(tǒng)計(jì)學(xué)意義。
[Abstract]:Objective: To explore the correlation between glycated albumin level and acute light ischemic stroke, and to further analyze the differences of glycated albumin levels in acute light ischemic stroke patients with different etiological types, and to provide a theoretical basis for the diagnosis and treatment of acute light ischemic stroke with different etiological types. Methods: from December 2014 to December 2016. 145 patients with acute light ischemic stroke in the Department of Neurology in our hospital were screened for the risk factors of cerebrovascular disease in each case, and the serum glycosylated albumin index was detected, and then the CISS apoplexy etiological classification was carried out according to the MRI, MRA or CTA examination of the patients, and 84 cases of large atherosclerotic type (LAA) light stroke patients were selected. 61 cases of arterial disease type (PAD) with light stroke were selected as normal controls in 130 cases without stroke in the physical examination center of our hospital. The vascular risk factors of acute light ischemic stroke group and non stroke control group, fasting blood glucose and glycated albumin level were compared, and the age, sex and hypertension were further compared. Whether diabetes, hyperlipidemia, fasting blood glucose and glycated albumin levels were statistically significant in group LAA and group PAD. Results: compared with the non stroke control group, hypertension, diabetes, hyperlipidemia, smoking history, fasting blood glucose and glycated albumin levels were significantly higher in the case group than in the control group (all P0.05). In the group analysis, the glycosylated albumin level in the light stroke group was significantly higher than that in the non stroke control group [(21.3 + 4.7)% (17.2 + 1.9)%, P0.01], and a similar conclusion in the non diabetic subgroup. Multiple factor Logistic regression analysis showed that in the general population, the diabetes subgroup or the non sugar after the normal risk factors were seen in the school. In the urine subgroup, the increased glycated albumin level was the independent risk factor of acute light ischemic stroke (P0.05) group.LAA and group PAD. The difference of common risk factors of age, sex and hyperlipidemia was statistically significant (P0.05), but there was no statistical difference between the fasting blood sugar and the glycosylated albumin level in the two groups. P0.05. Conclusion: This study suggests that glycated albumin is significantly associated with acute light ischemic stroke. The increased glycated albumin level is an independent risk factor for acute light ischemic stroke, and there is no significant difference in the level of glycated albumin in the LAA group and the PAD group.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R743.3

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