本文選題：嬰兒 + 早產(chǎn)��； 參考：《中國循證兒科雜志》2017年01期

【摘要】：目的了解超早產(chǎn)兒(胎齡28周)腦病的發(fā)生狀況并探討其發(fā)生的危險因素。方法收集復(fù)旦大學附屬兒科醫(yī)院NICU 2009年1月1日至2015年12月31日期間住院的、出生胎齡28周的、于糾正胎齡足月時或出院前完成MRI檢查的超早產(chǎn)兒,排除糾正胎齡或出院時MRI單純腦出血的病例。根據(jù)頭顱MRI影像學報告結(jié)果分為單純EOP組、EOP+出血組和正常組,采集與發(fā)生EOP可能相關(guān)的母親和新生兒影響因素,三組之間進行單因素比較。結(jié)果 115例超早產(chǎn)兒進入本文分析,單純EOP組20例,EOP+出血組15例,正常組80例。35例EOP患兒中,白質(zhì)損傷31例(88.6%),灰質(zhì)損傷4例(11.4%),小腦損傷3例(8.6%),多發(fā)廣泛損傷1例(2.9%),白質(zhì)合并小腦損傷2例(5.7%)。腦白質(zhì)損傷中,腦室周圍白質(zhì)損傷17例,其中非囊性損傷16例,囊性PVL1例;皮層下白質(zhì)損傷14例,其中額葉損傷7例。單因素分析顯示,單純EOP組、EOP+出血組、正常組3組比較,母親因素和新生兒因素差異均無統(tǒng)計學意義(P均0.05)。結(jié)論超早產(chǎn)兒EOP與早產(chǎn)兒腦病一樣最多見于腦白質(zhì)損傷,影響超早產(chǎn)兒腦病為非單一危險因素起作用。
[Abstract]:Objective to investigate the incidence and risk factors of encephalopathy in ultra-premature infants (28 weeks of gestational age). Methods Ultra premature infants hospitalized in NICU Hospital of Pediatrics affiliated to Fudan University from January 1, 2009 to December 31, 2015, and 28 weeks of gestational age, who completed MRI examination before correcting gestational age or were discharged from hospital, were collected. Cases of MRI simple intracerebral hemorrhage were excluded and corrected at gestational age or discharge. According to the results of cranial MRI imaging, the patients were divided into simple EOP group and normal group. The maternal and neonatal factors associated with the occurrence of EOP were collected, and univariate comparison was made among the three groups. Results 115 cases of super premature infants were analyzed in this paper. There were 15 cases in EOP group, 80 cases in normal group, and 35 cases in EOP group, 20 cases in simple EOP group, 15 cases in EOP bleeding group and 80 cases in normal group. There were 31 cases of white matter injury, 4 cases of gray matter injury, 3 cases of cerebellar injury and 8.6%, 1 case of multiple extensive injury, 2 cases of white matter with cerebellum injury and 2 cases of cerebellum injury. There were 17 cases of white matter injury around the ventricle, including 16 cases of non-cystic injury, 16 cases of cystic PVL1 and 14 cases of subcortical white matter injury, including 7 cases of frontal lobe injury. Univariate analysis showed that there was no significant difference in maternal and neonatal factors between EOP group and normal group (P < 0.05). Conclusion EOP is the most common cause of white matter injury in ultra premature infants as well as encephalopathy in preterm infants.
【作者單位】： 復(fù)旦大學附屬兒科醫(yī)院新生兒科;
【分類號】：R742

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本文編號：1960153