本文選題：帕金森病 + tau蛋白��； 參考：《中國(guó)老年學(xué)雜志》2017年15期

【摘要】：目的分析帕金森病(PD)患者血清tau蛋白磷酸化水平與預(yù)后轉(zhuǎn)歸的關(guān)系。方法選取接受治療的PD患者100例作為觀察組,另取同期健康體檢者100例為對(duì)照組。分別采用雙抗體夾心酶聯(lián)免疫吸附法檢測(cè)所有研究對(duì)象的血清磷酸化tau蛋白水平。同時(shí),根據(jù)PD患者認(rèn)知障礙程度的不同分為輕度認(rèn)知障礙(MCI組)44例及PD癡呆(PDD組)56例,對(duì)比兩組血清磷酸化tau蛋白水平,此外,將觀察組患者根據(jù)治療后PD統(tǒng)一評(píng)分量表(UPDRS)評(píng)分的不同分為UPDRS35分組以及UPDRS≥35分組,對(duì)比兩組血清磷酸化tau蛋白水平,并作Spearman相關(guān)性分析。結(jié)果觀察組患者血清磷酸化tau水平為(115.5±56.2)pg/ml,顯著高于對(duì)照組[(79.7±40.3)pg/ml,P0.05]。MCI組患者血清磷酸化tau水平顯著低于PDD組(P0.05)。UPDRS35分組血清磷酸化tau水平顯著低于UPDRS≥35分組(P0.05)。經(jīng)Spearman相關(guān)性分析可得,血清磷酸化tau水平與PD患者UPDRS評(píng)分呈顯著正相關(guān)(r=0.563,P=0.011)。結(jié)論 PD患者血清tau蛋白磷酸化水平越高,預(yù)后越差。
[Abstract]:Objective to analyze the relationship between serum tau protein phosphorylation and prognosis in patients with Parkinson's disease (PD). Methods 100 PD patients were selected as observation group and 100 healthy persons as control group. The levels of serum phosphorylated tau protein were detected by double antibody sandwich enzyme linked immunosorbent assay (Elisa). At the same time, according to the degree of cognitive impairment in PD patients, they were divided into mild cognitive impairment group (44 cases) and PD dementia group (56 cases). The serum levels of phosphorylated tau were compared between the two groups. The patients in the observation group were divided into UPDRS35 group and UPDRS 鈮，

本文編號(hào)：1898556