本文選題：頸動(dòng)脈狹窄 + 腦缺血事件��； 參考：《浙江大學(xué)》2017年碩士論文

【摘要】：目的探討頸動(dòng)脈狹窄病人繼發(fā)腦缺血事件的危險(xiǎn)因素。方法回顧性分析2013年1月至2016年9月浙醫(yī)二院神經(jīng)外科收治的169例手術(shù)治療的頸動(dòng)脈狹窄病人,其中符合腦缺血事件組(實(shí)驗(yàn)組)納入標(biāo)準(zhǔn)的有84例,符合無(wú)腦缺血事件組(對(duì)照組)納入標(biāo)準(zhǔn)的有28例。通過(guò)單因素及多因素Logistic回歸分析方法,分析年齡、性別、BMI、高血壓病史、糖尿病病史、高脂血癥病史、冠心病病史、抽煙史、飲酒史、血糖水平、膽固醇水平、甘油三酯水平、HDL水平、LDL水平、頸動(dòng)脈狹窄程度、斑塊內(nèi)新生血管級(jí)別、斑塊內(nèi)出血、左心室肥厚與腦缺血事件的關(guān)系。結(jié)果實(shí)驗(yàn)組的新生血管級(jí)別要顯著高于對(duì)照組(p=0.030),實(shí)驗(yàn)組狹窄程度在重度及以上的病人比例雖然高于對(duì)照組(78.57%vs60.71%),但其并不存在顯著差異(p=0.289),而其他因素如年齡,性別,BMI,既往高血壓、糖尿病、冠心病、高脂血癥、抽煙史、飲酒史等病史,斑塊內(nèi)出血,左心室肥厚,膽固醇,甘油三酯,HDL,LDL均與腦缺血事件無(wú)顯著相關(guān)性(p0.05)。多因素分析結(jié)果證明斑塊內(nèi)新生血管級(jí)別是繼發(fā)腦缺血事件的獨(dú)立危險(xiǎn)因素(p=0.011,95%CI=1.313-7.957)。結(jié)論頸動(dòng)脈狹窄病人的斑塊內(nèi)新生血管級(jí)別與腦缺血事件發(fā)生史密切相關(guān),而其他因素如年齡、性別、抽煙史、血糖水平、膽固醇水平、甘油三酯水平、LDL水平等則與腦缺血事件的發(fā)生無(wú)明顯聯(lián)系。
[Abstract]:Objective to investigate the risk factors of secondary cerebral ischemia in patients with carotid artery stenosis. Methods from January 2013 to September 2016, 169 patients with carotid artery stenosis treated in neurosurgery department of Zhejiang Medical second Hospital were retrospectively analyzed. Among them, 84 cases met the criteria of cerebral ischemia event group (experimental group). There were 28 patients who met the inclusion criteria in the control group (control group). Age, sex, hypertension, diabetes, hyperlipidemia, coronary heart disease, smoking, alcohol consumption, blood glucose level and cholesterol level were analyzed by univariate and multivariate Logistic regression analysis. Triglyceride level HDL level LDL level, carotid artery stenosis, intraplaque neovascularization, plaque hemorrhage, left ventricular hypertrophy and cerebral ischemia events. Results the grade of neovascularization in the experimental group was significantly higher than that in the control group (P 0.030). Although the proportion of patients with severe stenosis in the experimental group was higher than that in the control group (78.57 vs 60.71), there was no significant difference in the grade of neovascularization between the two groups. Diabetes, coronary heart disease, hyperlipidemia, smoking history, drinking history, plaque hemorrhage, left ventricular hypertrophy, cholesterol, triglyceride HDL- LDL were not significantly correlated with cerebral ischemia events (P 0.05). Multivariate analysis showed that intraplaque neovascularization was an independent risk factor for secondary cerebral ischemia events. Conclusion Intra-plaque neovascularization in patients with carotid artery stenosis is closely related to the history of cerebral ischemia events, while other factors such as age, sex, smoking history, blood glucose level, cholesterol level, etc. Triglyceride levels and LDL levels were not significantly associated with cerebral ischemic events.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R743.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

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