本文選題：干細胞 + 移植　； 參考：《東南大學學報(醫(yī)學版)》2016年06期

【摘要】：目的:系統評價及Meta分析干細胞移植治療缺血性腦卒中的臨床療效和安全性。方法:計算機檢索Cochrane Library、Pub Med、Ovid、CBM、中國知網、萬方和維普數據庫,檢索干細胞移植治療缺血性腦卒中的隨機對照研究(RCT),檢索時限從建庫至2015年12月。所有檢索后的文獻由2位作者按照納入與排除標準分別獨立進行文獻篩選和數據資料提取及偏倚風險評價,并采用Rev Man5.3軟件進行Meta分析。結果:共納入16個研究(18個獨立干預治療)進行Meta分析,得到的結果如下(使用各結局指標的基線終值差進行合并):神經功能缺損評分(NIHSS)(MD=1.57,95%CI 0.64~2.51,I2=57%,P=0.001)、運動功能FMA(MD=4.23,95%CI 3.08~5.38,I2=0%,P0.000 01)、日常生活能力Barthel(MD=8.37,95%CI 4.83~11.91,I2=63%,P0.000 01)和功能獨立性FIM(MD=8.89,95%CI 4.70~13.08,I2=79%,P0.000 1)等結局指標合并后(干細胞移植組和對照組的均數差MD)的結果均是有利于干細胞移植治療組,且各差異均有統計學意義。結論:干細胞治療對缺血性腦卒中病人的神經功能和日常生活質量均有不同程度的改善,且不良反應少。但是還需要更多高質量的大數據隨機對照研究來進一步證實干細胞移植治療的有效性。
[Abstract]:Objective: to evaluate the efficacy and safety of stem cell transplantation in the treatment of ischemic stroke. Methods: the Cochrane Library Pub MedOvidCIM, the China Zhiwang, Wanfang and Weipu databases, and the randomized controlled study of stem cell transplantation in the treatment of ischemic stroke were searched. The search time was from the establishment of the database to December 2015. All the retrieved documents were independently selected by the two authors according to the inclusion and exclusion criteria, and the data extraction and bias risk evaluation were carried out, respectively, and Meta analysis was carried out with Rev Man5.3 software. Results: Meta analysis was performed in 16 subjects (18 independent intervention therapy). 寰楀埌鐨勭粨鏋滃涓，

本文編號：1889938