本文選題：腦梗死 + 2型糖尿病��； 參考：《石河子大學(xué)》2014年碩士論文

【摘要】：目的探討2型糖尿病合并腦梗死患者血清視黃醇結(jié)合蛋白4（RBP4）水平及其意義。 方法選取2012年11月—2013年7月在石河子大學(xué)第一附屬醫(yī)院住院的30例2型糖尿病患者（DM組）、30例腦梗死患者（CI組）、30例2型糖尿病合并腦梗死患者（DM+CI組）及30例同期體檢健康者（對(duì)照組）。記錄各組受檢者的一般信息及實(shí)驗(yàn)室檢查結(jié)果，比較各組血清RBP4水平；采用Spearman’s相關(guān)分析RBP4的相關(guān)因素；采用二分類Logistic回歸分析2型糖尿病并發(fā)腦梗死的影響因素。 結(jié)果（1）4組受檢者三酰甘油（TG）、低密度脂蛋白（LDL）、RBP4、糖化血紅蛋白（HbA1c）、胱抑素C、同型半胱氨酸（Hcy）水平間有差異（P＜0.05）；其中DM+CI組患者RBP4水平均高于其他3組（P0.05）。（2）血糖控制未達(dá)標(biāo)組（HbA1c＞6.5%）RBP4水平高于血糖控制達(dá)標(biāo)組〔（106.0±23.1）mg/L與（87.8±32.5）mg/L，，t=-3.539；P=0.001〕。（3）血清TC、TG、LDL水平均與RBP4呈正相關(guān)（r值分別為0.430、0.432和0.681；P=0.001）。（4）以DM患者是否合并DI做因變量的二分類Logistic回歸分析發(fā)現(xiàn)RBP4（OR=1.023P=0.046）和Hcy（OR=1.130P=0.040）均為糖尿病合并腦梗死的危險(xiǎn)因素。 結(jié)論（1）2型糖尿病合并腦梗死患者血清RBP4水平升高，提示RBP4可作為2型糖尿病患者并發(fā)腦梗死的臨床生物學(xué)指標(biāo)；（2）血清RBP4水平升高與血糖控制不達(dá)標(biāo)有關(guān)，提示需更改降糖方案；（3）血清TC、TG、LDL水平與RBP4水平呈正相關(guān)，提示兼顧血脂治療的重要性。
[Abstract]:Objective to investigate the level and significance of retinol binding protein 4 (RBP 4) in patients with type 2 diabetes mellitus complicated with cerebral infarction. Methods from November 2012 to July 2013, 30 patients with type 2 diabetes mellitus and 30 patients with cerebral infarction were enrolled in the first affiliated Hospital of Shihezi University. Healthy persons (control group). The general information and laboratory results of each group were recorded to compare the serum RBP4 levels in each group, Spearman's correlation analysis was used to analyze the related factors of RBP4, and two classification Logistic regression analysis was used to analyze the influencing factors of type 2 diabetes mellitus complicated with cerebral infarction. Results there were significant differences in the levels of triacylglycerol (TGG), low density lipoprotein (LDL-C) (RBP4), glycosylated hemoglobin (HbA1cP), cystatin C (C) and homocysteine (Hcyn) between the four groups (P < 0.05), and the RBP4 levels in the DM CI group were higher than those in the other three groups (P0.05. 0. 5, P < 0. 05, P < 0. 05, P < 0. 05). HbA1c > 6.5%)RBP4 levels were significantly higher than those in blood glucose control group (106.0 鹵23.1)mg/L and 87.8 鹵32.5 mg / L). The serum levels of TCA-TGG were positively correlated with RBP4, respectively, 0.4300.32 and 0.681P0.001n.4. respectively. The results of two-classification Logistic regression analysis of whether DM patients were complicated with DI were found to be diabetes mellitus (RP4ORP 1.023P0.046) and HcyOR1.130P0.040). Risk factors of cerebral infarction. Conclusion the increase of serum RBP4 level in patients with type 2 diabetes mellitus complicated with cerebral infarction suggests that RBP4 can be used as a clinical biological index of type 2 diabetes mellitus complicated with cerebral infarction.) the increase of serum RBP4 level is related to the substandard of blood glucose control. It was suggested that the level of serum TCU TGG / LDL was positively correlated with the level of RBP4, indicating the importance of taking into account the treatment of blood lipids.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R587.1;R743.3

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本文編號(hào)：1873447