本文選題：快動眼睡眠期行為障礙 + 帕金森病��； 參考：《重慶醫(yī)科大學(xué)》2017年碩士論文

【摘要】：背景:快動眼睡眠行為障礙(Rapid eye movement sleep behavior disorder,RBD)是帕金森病(Parkinson’s disease,PD)中最常見的非運動癥狀之一,它可以增加PD患者認知受損的風(fēng)險,是預(yù)測PD病情惡化的標志之一。但PD伴RBD患者(patient with PD and RBD,PDR)的發(fā)病機制尚不清楚,相關(guān)研究提示認知控制機制缺陷可能在PDR中起著一定的作用,前扣帶回皮層(Anterior cingulate cortex,ACC)作為認知控制機制中重要的部分,可能參與PDR的病理生理機制。方法:本試驗分別納入15名不伴有RBD的PD患者(patients with PD but no RBD,n PDR),15名伴PDR患者,和17名相匹配的正常對照(healthy controls,HCs)。所有的受試者需要接受靜息態(tài)功能磁共振(resting-state functional MRI,RS-f MRI)和神經(jīng)心理評估。我們采用以雙側(cè)ACC為感興趣區(qū)的全腦靜息態(tài)功能連接(resting-state functional connectivity,RS-FC)的方法來研究三組間ACC功能連接模式變化情況。結(jié)果:我們發(fā)現(xiàn)PD患者雙側(cè)ACC均表現(xiàn)出異常的功能連接改變。與正常對照相比,n PDR與PDR患者的ACC功能連接減弱區(qū)均主要分布于額葉、頂葉、顳葉、枕葉、扣帶回等區(qū)域。但PDR功能連接改變涉及團塊范圍更大,同時還在小腦、腦橋區(qū)域也呈現(xiàn)出減弱的ACC功能連接。對比n PDR組,PDR組ACC功能連接減弱主要是在前額葉皮質(zhì)(prefrontal cortex,PFC)、顳下皮層(inferior temporal cortex,IT cortex)、小腦和腦橋等區(qū)域。此外,左側(cè)ACC還與輔助運動區(qū)(supplementary motor area,SMA)表現(xiàn)出減弱的功能連接。結(jié)論:PDR和n PDR患者均存在異常的ACC功能連接,PDR患者涉及范圍更廣,提示PDR較n PDR可能存在更嚴重的認知控制機制缺陷,且異常的認知控制機制可能在PDR的病理生理機制中起著一定作用。
[Abstract]:Background: rapid eye movement sleep behavior disorder (RBD) is one of the most common nonmotor symptoms in Parkinson's disease (PD). It can increase the risk of cognitive impairment in PD patients and is one of the markers to predict the deterioration of PD. However, the pathogenesis of with PD and in PD patients with RBD is still unclear. The related studies suggest that the defect of cognitive control mechanism may play a role in PDR, and the anterior cingulate cortex cingulate cortexACCas an important part of cognitive control mechanism. It may be involved in the pathophysiological mechanism of PDR. Methods: 15 PD patients without RBD were enrolled in this study, 15 patients with PDR and 17 matched normal controls. All subjects were subjected to rest state functional MRI RS-f MRI and neuropsychological assessment. In this paper, we use the method of resting-state functional connectivity (RS-FC) with bilateral ACC as the region of interest to study the changes of ACC functional connection mode among the three groups. Results: we found that bilateral ACC showed abnormal functional junction changes in PD patients. Compared with the normal controls, the ACC functional junctional regions of the patients with PDR and PDR were mainly distributed in the frontal lobe, parietal lobe, temporal lobe, occipital lobe, cingulate gyrus and so on. However, the change of PDR functional junction involved a larger area of mass, but also in the cerebellum, the pons area also showed a weakened ACC functional connection. Compared with n PDR group, the decrease of ACC functional junctions was mainly in prefrontal cortical prefrontal cortex, inferior temporal cortexa IT cortexa, cerebellum and pons. In addition, the left ACC also showed a weakened functional connection with the supplementary motor SMA. Conclusion the presence of abnormal ACC functional junctions in patients with both ACC and n PDR may involve a wider range of patients, suggesting that PDR may have more severe cognitive control mechanism defects than n PDR. Abnormal cognitive control may play a role in the pathophysiological mechanism of PDR.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R742.5

【參考文獻】

相關(guān)期刊論文 前2條

1 馬端蘭;李剛;李振光;張建忠;于占彩;鄒佳霖;包衛(wèi)方;;經(jīng)顱超聲在早期帕金森病鑒別診斷中的應(yīng)用進展[J];中華臨床醫(yī)師雜志(電子版);2016年06期

2 扈楊;張巍;;帕金森病伴快速眼動睡眠期行為障礙[J];生理科學(xué)進展;2015年03期

，

本文編號：1843469