發(fā)布時(shí)間：2018-05-02 15:25

  本文選題：Adropin + 腦梗死��； 參考：《中風(fēng)與神經(jīng)疾病雜志》2017年04期

【摘要】：目的分析腦梗死患者頸動(dòng)脈內(nèi)中膜厚度(IMT)與血清Adropin水平之間的關(guān)系,探討血清Adropin在動(dòng)脈粥樣硬化評(píng)估中的預(yù)測(cè)價(jià)值。方法選取84例腦梗死患者,用彩色多普勒超聲診斷儀檢測(cè)頸動(dòng)脈IMT,分為內(nèi)膜正常組(n=20)、內(nèi)膜增厚組(n=38)、斑塊形成組(n=26),采用酶聯(lián)免疫吸附法(ELISA)檢測(cè)血清Adropin含量,分析頸動(dòng)脈IMT與血清Adropin水平的相關(guān)性。結(jié)果 IMT正常組血清Adropin水平明顯高于IMT增厚組和IMT斑塊組(均P0.01),IMT增厚組血清Adropin水平明顯高于IMT斑塊組(P0.01),相關(guān)性分析顯示,頸動(dòng)脈IMT與年齡(r=0.342,P=0.001)、收縮壓(r=0.536,P=0.000)、LDL-C(r=0.285,P=0.009)、尿酸(r=0.282,P=0.009)呈正相關(guān),與Adropin呈明顯負(fù)相關(guān)(r=-0.500,P=0.000);Logistic回歸分析顯示年齡、尿酸、LDL-C、收縮壓、Adropin下降是頸動(dòng)脈硬化的獨(dú)立危險(xiǎn)因素。結(jié)論血清Adropin水平隨著頸動(dòng)脈硬化程度加重而下降,在一定程度上可反映頸動(dòng)脈粥樣硬化嚴(yán)重程度。
[Abstract]:Objective to analyze the relationship between carotid intima-media thickness (IMT) and serum Adropin levels in patients with cerebral infarction, and to explore the predictive value of serum Adropin in the evaluation of atherosclerosis. Methods Eighty-four patients with cerebral infarction were divided into normal endometrium group (n = 20), intimal thickening group (n = 38), plaque formation group (n = 26), carotid artery Adropin by color Doppler ultrasound. The serum Adropin level was detected by enzyme linked immunosorbent assay (Elisa). To analyze the correlation between carotid IMT and serum Adropin level. Results the level of serum Adropin in normal IMT group was significantly higher than that in IMT thickening group and IMT plaque group (all P0.01P 0.01). The correlation analysis showed that carotid IMT was positively correlated with age 0.342P0. 001G, SBP 0.536P0. 000, LDL-Cr 0.285 P0. 009, uric acid r0. 282 P0. 009). Logistic regression analysis showed that the decrease of LDL-C and systolic blood pressure were independent risk factors of carotid atherosclerosis. Conclusion Serum Adropin level decreases with the severity of carotid atherosclerosis, which can reflect the severity of carotid atherosclerosis to some extent.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京天壇醫(yī)院神經(jīng)病學(xué)中心;
【分類號(hào)】：R743.33
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本文編號(hào)：1834459