本文選題：臭氧自血療法 + 急性腦梗死�。� 參考：《吉林大學(xué)》2014年碩士論文

【摘要】：臭氧治療腦梗塞及其后遺癥的原理是通過醫(yī)用臭氧與人體血液混合發(fā)生生化反應(yīng)，生成一些生物促進(jìn)因子和充足的氧氣，從而達(dá)到溶解血栓、提高紅細(xì)胞攜氧能力、加快血液流速、降低血液粘性，溶解血管壁上的脂類雜質(zhì)、恢復(fù)血管彈性，營養(yǎng)神經(jīng)，恢復(fù)神經(jīng)功能的作用。 目的：通過觀察臭氧自血療法在腦梗死治療方面的療效，觀察臭氧對腦梗死患者血脂的改變、評價(jià)臭氧對腦梗死患者神經(jīng)功能缺損的影響、同時(shí)觀察臭氧治療的安全性，包括不良反應(yīng)、合并癥的發(fā)生，為臭氧治療腦梗死這一新方法提供臨床依據(jù)，以期減少后遺癥的發(fā)生，提高患者的生活質(zhì)量。 方法：納入2013年至2014年我院神經(jīng)內(nèi)科收入院的急性腦梗死患者130例，隨機(jī)分為對照組65例和實(shí)驗(yàn)組65例，兩組性別、年齡、體重指數(shù)、既往病史、發(fā)病時(shí)間等資料無統(tǒng)計(jì)學(xué)差異(P0.05)，具有可比性。對照組只給予活血化瘀、清除自由基、抗血小板聚集、調(diào)整血脂等基礎(chǔ)用藥及系統(tǒng)規(guī)范康復(fù)治療。實(shí)驗(yàn)組在上述治療的基礎(chǔ)上加用臭氧自血療法，具體操作步驟：應(yīng)用德國郝爾曼多功能臭氧系統(tǒng)，1次/天，治療10天�；颊呷朐�24h、住院治療2周后(第15天)，分別于清晨空腹12小時(shí)以上的情況下抽取肘靜脈血5ml，采用日立7600全自動(dòng)生化儀及配套試劑測定甘油三脂(TG)、總膽固醇(TC)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)水平及血常規(guī)、肝功、腎功能�；颊呷朐�24小時(shí)、住院2周后(第15天)分別進(jìn)行神經(jīng)功能缺損程度評分及日常生活能力評分。本文采用NIHSS評分即美國國立衛(wèi)生院神經(jīng)功能缺損評分，采用Barthel指數(shù)，簡稱BI，評價(jià)日常生活能力。使用SAS9.0軟件進(jìn)行數(shù)據(jù)統(tǒng)計(jì)分析，各組計(jì)量資料用x s表示，組間比較使用ｔ檢驗(yàn)及秩和檢驗(yàn)；計(jì)數(shù)資料以率表示，組間比較采用χ２檢驗(yàn)，P 0.05為差異有統(tǒng)計(jì)學(xué)意義。 結(jié)果：治療前兩組患者血脂各項(xiàng)指標(biāo)均無統(tǒng)計(jì)學(xué)差異；治療2周后，兩組患者甘油三酯、總膽固醇和高密度脂蛋白各項(xiàng)指標(biāo)均無統(tǒng)計(jì)學(xué)差異（P0.05），低密度脂蛋白指標(biāo)差異具有統(tǒng)計(jì)學(xué)意義（P0.05）；實(shí)驗(yàn)組與對照組患者療效差異有統(tǒng)計(jì)學(xué)意義（Z=-2.14，P=0.02），總有效率實(shí)驗(yàn)組高于對照組。NIHSS評分結(jié)果顯示，治療前兩組評分差異無統(tǒng)計(jì)學(xué)意義；治療2周后，兩組評分中，肢體活動(dòng)和凝視指標(biāo)差異具有統(tǒng)計(jì)學(xué)意義（P0.05），其他指標(biāo)均無統(tǒng)計(jì)學(xué)差異（P＞0.05）；實(shí)驗(yàn)組與對照組NIHSS各項(xiàng)指標(biāo)差值評分中，面癱和肢體活動(dòng)指標(biāo)差異具有統(tǒng)計(jì)學(xué)意義（P0.05），其他指標(biāo)均無統(tǒng)計(jì)學(xué)差異（P＞0.05）；Barthel評分結(jié)果顯示，治療前兩組評分無統(tǒng)計(jì)學(xué)差異，，治療后兩組評分差異有統(tǒng)計(jì)學(xué)意義，兩組治療前后Barthel評分差值比較差異有統(tǒng)計(jì)學(xué)意義。治療過程中未發(fā)現(xiàn)明顯的不良反應(yīng)，兩組治療對血常規(guī)、肝功能、腎功能指標(biāo)均沒有不良影響。 結(jié)論：臭氧自血療法輔助治療腦梗死有較好療效，可改善患者神經(jīng)功能缺損、尤其對神經(jīng)功能的運(yùn)動(dòng)功能有較大改善，提高日常生活能力，減輕后遺癥程度，改善預(yù)后；也可改善血脂水平，尤其對降低低密度脂蛋白膽固醇及總膽固醇效果較好。且不良反應(yīng)少，安全性好，在臨床治療中值得推廣使用。
[Abstract]:The principle of ozone therapy for cerebral infarction and its sequelae is to produce some biological promoting factors and sufficient oxygen by mixing medical ozone with human blood to produce some biological promoting factors and sufficient oxygen to achieve thrombolytic thrombus, increase the oxygen carrying capacity of red blood cells, accelerate blood flow velocity, reduce blood viscosity, dissolve the lipid impurities on the blood vessel wall, and restore the vascular elasticity, Nourishment nerve, restore the function of nerve function.
Objective: To observe the curative effect of ozone self blood therapy in the treatment of cerebral infarction, observe the changes of the blood lipid of the patients with cerebral infarction, evaluate the effect of ozone on the nerve function defect of the patients with cerebral infarction, and observe the safety of the ozone treatment, including the adverse reaction and the occurrence of the complication, and provide the new method for the treatment of cerebral infarction by ozone. Clinical basis, in order to reduce the occurrence of sequelae and improve the quality of life of patients.
Methods: 130 cases of acute cerebral infarction in the Department of Neurology income Hospital of our hospital from 2013 to 2014 were randomly divided into 65 cases in the control group and 65 cases in the experimental group. The two groups of sex, age, body mass index, previous history, time of onset, and other data were not statistically different (P0.05). The control group was only given blood circulation to remove blood stasis, free radical scavenging, and anti blood small On the basis of the above treatment, the experimental group was added with ozone autologous blood therapy on the basis of the above treatment. The specific operation steps were: the German Herman multifunctional ozone system, 1 times / day, 10 days of treatment. The patients were admitted to hospital for 24h, and the hospitalization for 2 weeks (fifteenth days), respectively, more than 12 hours in the morning empty stomach. The blood 5ml of the elbow vein was extracted, and the Hitachi 7600 full automatic biochemical analyzer and the matching reagent were used to determine the glycerol three fat (TG), the total cholesterol (TC), the high density lipoprotein cholesterol (HDL-C), the low density lipoprotein cholesterol (LDL-C) level, the blood routine, the liver function and the renal function. The patients were admitted to hospital for 24 hours, and the neurological deficit course was carried out after 2 weeks of hospitalization (fifteenth days), respectively. Degree score and daily life ability score. The NIHSS score was used to score the neurological deficit of the National Institutes of health, and the Barthel index was used to evaluate daily living ability. The data were analyzed by SAS9.0 software. The measurement data of each group were expressed by x s, and the t test and rank sum test were used among the groups, and the count data were counted. The results showed that chi square test was used in comparison between groups, and P 0.05 was statistically significant in difference between 2 groups.
Results: there was no statistical difference between the two groups before the treatment. After 2 weeks of treatment, there was no statistical difference between the triglycerides, total cholesterol and high density lipoprotein in the two groups (P0.05), and the difference of low density lipoprotein index was statistically significant (P0.05), and the difference of curative effect between the experimental group and the control group was statistically significant. Significance (Z=-2.14, P=0.02), the total efficiency experimental group was higher than the control group.NIHSS score results showed that there was no significant difference between the two groups before the treatment. After 2 weeks of treatment, the differences of limb activity and gaze index in the two groups were statistically significant (P0.05), and the other indexes were not statistically different (P > 0.05), and the experimental group and the control group were NIHSS respectively. The difference between the facial paralysis and the limb activity index was statistically significant (P0.05), and the other indexes were not statistically different (P > 0.05). The results of Barthel score showed that there was no statistical difference between the two groups before treatment, and the difference between the two groups after the treatment was statistically significant, and the difference of the two groups before and after the treatment was different. No significant adverse reactions were found in the course of treatment. There was no adverse effect on blood routine, liver function and renal function in the two groups.
Conclusion: the adjuvant therapy of ozonemia has a good effect on cerebral infarction. It can improve the nerve function defect, especially improve the motor function of nerve function, improve the daily living ability, reduce the degree of sequelae, improve the prognosis, and also improve the blood lipid level, especially to reduce the low density lipoprotein cholesterol and total cholesterol. The fruit is good, and has few adverse reactions and good safety. It is worth popularizing in clinical treatment.

【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R743.3

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 賈紅云;賈淑云;;疏血通注射液與高壓臭氧大自血聯(lián)合治療急性腦梗死的療效及安全性觀察[J];中國醫(yī)藥導(dǎo)刊;2010年10期

2 覃善都;羅建春;馬利賢;付金梅;趙子粼;;臭氧置血治療腔隙性腦梗死伴腦動(dòng)脈硬化的臨床觀察[J];廣東醫(yī)學(xué);2012年22期

3 李德奎;劉躍;朱清紅;朱名安;;腦梗死患者同型半胱氨酸、凝血功能、血小板參數(shù)和血液流變學(xué)指標(biāo)檢測的臨床意義[J];國際檢驗(yàn)醫(yī)學(xué)雜志;2014年10期

4 林永忠;孫長凱;宋桂榮;胡增春;尹琳;姜長斌;包禮平;;阿托伐他汀治療腦梗死中運(yùn)動(dòng)捕捉與運(yùn)動(dòng)評估量表和Barthel指數(shù)療效評價(jià)的比較[J];中國臨床神經(jīng)科學(xué);2006年02期

5 吳守方;;不同時(shí)間窗進(jìn)行腦梗死溶栓治療的效果及安全性評價(jià)[J];中國實(shí)用神經(jīng)疾病雜志;2014年03期

6 路旭;胡英;;氫氯吡格雷聯(lián)合尤瑞克林治療高齡腦梗死的療效及對神經(jīng)功能缺損和血液流變學(xué)的影響[J];中國實(shí)用神經(jīng)疾病雜志;2014年09期

7 胡小娟;劉寧;包麗娟;;血清Hcy水平與合并2型糖尿病的急性腦梗死相關(guān)性分析[J];中國實(shí)用神經(jīng)疾病雜志;2014年09期

8 李云愷;陳麗艷;王惠;邱思強(qiáng);;臭氧、臭氧水對感染性創(chuàng)面修復(fù)作用的分子生物學(xué)研究[J];海南醫(yī)學(xué);2014年10期

9 張步環(huán);王宏;賈文霄;鄧佳敏;;DTI及DTT技術(shù)與NIHSS評分系統(tǒng)在急性腦梗死患者預(yù)后評價(jià)中的對比研究[J];臨床放射學(xué)雜志;2014年06期

10 蔣成志;李建峰;;醫(yī)用臭氧大自血治療高膽固醇血癥的療效觀察[J];內(nèi)蒙古中醫(yī)藥;2014年03期

本文編號(hào)：1821526