本文選題：CT值 + 體模��； 參考：《河北醫(yī)科大學》2017年碩士論文

【摘要】：第一部分模擬體模的選擇與“仿生病灶”模型的制做目的:優(yōu)選和制做適用于本研究的頭頸部仿生體模及病灶模型。方法:選擇了成都方拓仿真技術有限責任公司生產(chǎn)的“仿真輻照男性頭頸部病灶模擬體模”,并研究出一種“仿生病灶”的“模具”制做方法,使“仿生病灶”更具有仿生性�！胺律≡睢本哂袃�(nèi)部均勻性和邊緣可識別性,具有“毛刺”結構和“分葉”結構。在病灶制做過程中制定了完善的質(zhì)控和質(zhì)保體系,保證了仿生模型的質(zhì)量,滿足了64排螺旋CT多模態(tài)掃描研究的基本技術條件要求。在分析前,先做好參研人員的任務培訓工作,再獲得的CT圖像。結果:用此體模進行了64排螺旋CT多模態(tài)(參數(shù)與方位)的掃描,包括不同參數(shù)條件的橫斷面、矢狀面和冠狀面掃描,獲得了大量的圖像數(shù)據(jù)。為保證每一次64排螺旋CT掃描的圖像質(zhì)量,均在每一次實驗前先做好64排螺旋CT機的技術參數(shù)校準,實現(xiàn)實驗結果的同質(zhì)化,而獲得的圖像均在PACS系統(tǒng)狀態(tài)下進行圖像的閱讀與測量。結論:1優(yōu)化選擇了適用于該實驗的成都方拓仿真技術有限責任公司生產(chǎn)的“仿真輻照男性頭頸部病灶模擬體�！薄�2研究制做了適用于此實驗的“仿生病灶”模型。3為保證圖像質(zhì)量,研究了一種體模合攏時的排氣法與工藝。4采取多參數(shù)狀態(tài)下對“仿生病灶”進行了橫斷面、冠狀面和矢狀面64排螺旋CT多模態(tài)掃描。5重點了解了不同參數(shù)不同方位的64排螺旋CT多模態(tài)掃描技術對病灶圖像質(zhì)量的關系。第二部分CT圖像的測量方法與數(shù)據(jù)的采集目的:優(yōu)化和研究適用于本實驗的CT圖像閱讀與測量的科學方法,精細測量不同參數(shù)CT掃描方位的數(shù)據(jù)。方法:將制做好的頭頸部體模擺放固定在GE Optima CT660 64排螺旋CT掃描床上,按預設置的部位、方位和掃描參數(shù)進行CT掃描。把獲得的CT圖像收集儲存在PACS系統(tǒng)上,以備集中分析。采用了自制的“感興趣區(qū)CT值測量定位坐標尺”進行CT圖像閱讀和測量。測量前先培訓了參研人員,使所測數(shù)據(jù)同質(zhì)化。并重點對不同參數(shù),不同方位CT掃描圖像上的CT值和毛刺、分葉征象進行了系統(tǒng)的測量。結果:獲得了能滿足本研究的高質(zhì)量64排螺旋CT掃描圖像,并對所有的圖像進行歸納、整理和詳細的測量,獲得了大量的數(shù)據(jù),發(fā)明了供CT圖像測量的工具,保證了本實驗的順利完成。結論:1進行了頭部體�！胺律≡钅Ｐ汀�64排螺旋CT的掃描圖像的數(shù)據(jù)采集,歸納和整理。2研發(fā)了適用于CT圖像和CT值測定的工具,具有先進性。3進行了對“仿生病灶模型”64排螺旋CT多模態(tài)掃描多方位圖像的病灶毛刺、分葉、邊緣清晰度等項目的測量和分析。第三部分數(shù)據(jù)統(tǒng)計與數(shù)據(jù)分析目的:科學分析實驗數(shù)據(jù)和信息,進行統(tǒng)計學分析與評估,獲得有效的結果。方法:數(shù)據(jù)采集采用社會科學統(tǒng)計軟件包(簡稱SPSS,版本號:19.0)進行統(tǒng)計分析。數(shù)據(jù)分析前,先制定了本研究數(shù)據(jù)分析的1-22個分析點:1 mA值變化與病灶CT值(N0,N1,N2,N3,N4)變化;2 kV值變化與病灶CT值(N0,N1,N2,N3,N4)變化;3 mA,kV值變化與病灶CT值(N0,N1,N2,N3,N4)變化;4 mA值變化與病灶毛刺顯示率與CT值變化;5 kV值變化與病灶毛刺顯示率與CT值變化;6 mA,kV值共享時病灶毛刺顯示率與CT值變化;7 mA值變化與病灶分葉征顯示率與CT值變化;8 kV值變化與病灶分葉征顯示率與CT值變化;9 mA,kV值共享時與病灶分葉征顯示率與CT值變化;10 mA值變化對病灶邊緣大小(最大橫徑,最大縱徑)變化影響;11 kV值變化對病灶邊緣大小(最大橫徑,最大縱徑)變化影響;12 mA,kV值變化對病灶邊緣大小(最大橫徑,最大縱徑)變化影響;13 mA值變化對病灶矢狀面顯示情況的影響;14 kV值變化對病灶矢狀面顯示情況的影響;15 mA,kV值變化對病灶矢狀面顯示情況的影響;16 mA值變化對病灶冠狀面顯示情況的影響;17 kV值變化對病灶冠狀面顯示情況的影響;18 mA,kV值變化對病灶冠狀面顯示情況的影響;19 mA值變化對病灶橫斷面顯示情況的影響;20 kV值變化對病灶橫斷面顯示情況的影響;21 mA,kV值變化對病灶橫斷面顯示情況的影響;22各數(shù)據(jù)相互間的關系與相互間求證和基本假設。系統(tǒng)分別對這些分析點進行了數(shù)計統(tǒng)計和分析,并用相應的表格進行表述。結果:通過數(shù)據(jù)分析和統(tǒng)計評價顯示,64排螺旋CT多模態(tài)掃描技術對各種參數(shù)的優(yōu)化和選擇非常重要,如果不科學地降低kV和mA值能顯著地導致圖像質(zhì)量的下降,影響病灶微細結構的觀察和顯示。也能影響病灶CT值的某些變化。如采用150mA掃描時其CT值會有小幅度的假高現(xiàn)象。結論:1直接在“仿真輻照男性頭頸部病灶模擬體�！蹦X組織區(qū)域進行制做的“仿生病灶”可達到良好的仿真形態(tài),并且這一方法在現(xiàn)有文獻報道中尚未提及,是本實驗的創(chuàng)新點。2“橡皮泥圍壩排氣法“是一種廉價且實用的方法,尚未有文獻報道,應可以更廣泛的應用到科研工作中。3病灶的同一層面在不同條件參數(shù)的64排螺旋CT掃描下呈現(xiàn)的形態(tài)是可以改變的,這一點在以往的文獻中未見報道。4制定了適用于該實驗獲得的圖像的閱讀與測量質(zhì)控體系。5研究出一種感興趣區(qū)CT值測量定位坐標尺。6摸索出了本研究CT圖像CT值感興趣區(qū)的選擇方法和毛刺,分葉測量方法。7對仿生模型64排螺旋CT多模態(tài)掃描獲得的數(shù)據(jù)進行了系統(tǒng)的統(tǒng)計和分析。8獲得了22項有意義的數(shù)據(jù)分析結果。9證實過度地降低CT掃描參數(shù)會顯著地降低CT圖像質(zhì)量,影響病灶顯示和診斷。10優(yōu)化64排螺旋CT低劑量掃描參數(shù)十分重要,實現(xiàn)標準化顯得更為重要。
[Abstract]:The first part is to simulate the selection of the body model and the purpose of the "bionic focus" model. To optimize and produce the head and neck bionic body model and focus model suitable for this study. Method: selected the simulated irradiated male head and neck simulated body model produced by the Chengdu square extension Simulation Technology Co., Ltd., and study a kind of "imitating illness". The "bionic focus" is more bionic. "Bionic focus" has internal uniformity and edge identifiability. It has a "burr" structure and a "lobuling" structure. In the process of making the focus, the quality control and quality assurance system is established. The quality of the bionic model is guaranteed and 64 rows of spiral CT are satisfied. The basic technical requirements of multi-modal scanning research are required. Before the analysis, the task training work of the participants is done and the CT images are obtained. Results: the 64 row helical CT multi mode (parameter and azimuth) scan, including the cross section of different parameter conditions, the sagittal plane and the coronal plane, is used to obtain a large amount of image data. In order to ensure the image quality of each 64 row spiral CT scanning, the technical parameters of the 64 row spiral CT are calibrated before each experiment to achieve the homogenization of the experimental results, and the obtained images are all read and measured in the state of the PACS system. Conclusion: 1 Optimization and selection of the Chengdu square extension simulation technology suitable for the experiment The "simulated irradiated male head and neck focus analog model" (.2) produced by the limited liability company has made the "bionic focus" model suitable for this experiment to ensure the image quality, and studied the cross section, coronal and sagittal shape of the "biomimetic focus" under the multi parameter state of the exhaust method and the process.4, when the body model closes. The surface 64 row spiral CT multi-modal scanning.5 focuses on the relationship between the 64 row spiral CT multi-modal scanning technology with different parameters and different directions. The measurement method of the second part of the CT image and the purpose of the data acquisition: optimize and study the scientific methods of reading and measuring the CT images suitable for this experiment, and the fine measurement of the different parameters CT scanning azimuth data. Method: put the finished head and neck body mold on the GE Optima CT660 64 row CT scanning bed, carry on the CT scan according to the pre set position, the azimuth and the scanning parameters. The obtained CT image collection is stored on the PACS system to prepare the centralized analysis. The self-made "CT value measurement positioning sitting" of the self-made region of interest is used. CT image reading and measurement. Before the measurement, the participants were trained to make the data homogenized. The CT values and burrs on different azimuth CT scanning images were systematically measured. Results: a high quality 64 row spiral CT scanning image which could satisfy this study was obtained, and all the images were obtained. Like induction, sorting and detailed measurement, a large number of data have been obtained, and a tool for CT image measurement has been invented to ensure the smooth completion of this experiment. Conclusion: 1 the data collection of the scanning image of the head model "bionic focus model" 64 rows of spiral CT was carried out, and the.2 developed a tool for CT image and CT value measurement. With advanced.3, the measurement and analysis of the lesions, lobuling and edge definition of the "bionic focus model" 64 row spiral CT multimodal scanning multidirectional images are carried out. The purpose of the third part data statistics and data analysis is to analyze the data and information of the experimental data and to carry out statistical analysis and evaluation, and to obtain effective results. Method: data acquisition is statistically analyzed by social science statistical software package (SPSS, version number 19). Before data analysis, 1-22 analysis points of this research data analysis are first made: changes of 1 mA values and CT values of the focus (N0, N1, N2, N3, N4), 2 kV values and CT values of the focus (N0, N1, N4) 1, N2, N3, N4) changes; changes in the 4 mA value and the change of the burr display rate and the CT value of the focus; the change of 5 kV value and the change of the burr display rate and the CT value of the focus; the change of the burr display rate and the CT value of the 6 mA and kV values; the change of the 7 mA value and the display rate of the lobule sign and the CT value; and the change of the change of the 8 value and the lobule sign and the value of the lesion; 9 The change of 10 mA value changes on the size of the lesion (maximum transverse diameter, maximum longitudinal diameter), and the change of the value of 11 kV on the size of the lesion (the maximum transverse diameter, the maximum longitudinal diameter), and the change of the value of kV on the size of the lesion (the maximum transverse diameter, the maximum longitudinal diameter), and the change of the 13 mA value to the disease. The influence of the display of the focus in the sagittal plane; the influence of the change of 14 kV value on the sagittal display of the focus; the influence of the change of 15 mA, kV on the display of the sagittal plane; the influence of the change of 16 mA on the coronary display of the focus; the influence of the 17 kV value on the coronary display of the focus; 18 mA, the change of the kV value on the coronal surface of the lesion. The influence of the 19 mA value changes on the transect display of the focus; the influence of the 20 kV value on the transect display of the focus; the influence of 21 mA, the change of the kV value on the transect display of the focus; the relationship between the 22 data and the mutual evidence and the basic hypothesis. Analysis and expression with the corresponding table. Results: through data analysis and statistical evaluation, the 64 row spiral CT multi-modal scanning technology is very important for the optimization and selection of various parameters. If the kV and mA values are not reduced scientifically, the decrease of the image quality can be significantly reduced, the observation and display of the microstructures of the lesions can also affect the disease. Some changes in the CT value of the focal point. For example, the CT value of the 150mA scan will have a small false high. Conclusion: 1 the "biomimetic focus" made directly in the brain tissue area of the "simulated irradiated male head and neck focus model" brain tissue can reach a good simulation form, and this method is not mentioned in the existing literature, and it is the reality. The innovative point.2 "rubber mud peri dam exhaust method" is a cheap and practical method. It has not been reported in literature. It should be widely applied to research work. The same level of.3 focus can be changed under the 64 row spiral CT scanning of different conditional parameters. This point has not been reported in the previous literature on the.4 system. The reading and measurement quality control system applied to the image obtained by this experiment.5 has studied a CT value measurement positioning coordinate scale in the region of interest.6 to find out the selection method and burr of the CT value region of the CT image of this study, and the system statistics of the data obtained by the lobuling method.7 for the bionic model 64 row helical CT multimode state scanning. And analysis.8 obtained 22 meaningful data analysis results.9 confirmed that excessive reduction of CT scanning parameters would significantly reduce the quality of CT images. It is very important to affect the display and diagnosis of.10 optimization of the low dose scanning parameters of 64 row spiral CT, and it is more important to achieve standardization.

【學位授予單位】：河北醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R741;R816.1

【參考文獻】

相關期刊論文 前7條

1 鄒煉;謝朝;吳琦;;3D虛擬模體設計軟件的開發(fā)[J];生物醫(yī)學工程學雜志;2014年01期

2 彭文獻;彭天舟;夏順仁;王曉陽;賈慶;付益謀;木國住;;X線管電壓對生物組織CT值影響的實驗研究[J];放射學實踐;2013年11期

3 張越;萬業(yè)達;何岸葦;傅菲;王楠;;不同管電壓下周圍結構對CT值測量影響的研究[J];天津醫(yī)科大學學報;2013年03期

4 張定均;;周圍型肺癌100例CT圖像特征分析[J];現(xiàn)代中西醫(yī)結合雜志;2013年06期

5 王曉華;馬大慶;陳卉;;毛刺征在CT診斷周圍型小肺癌中的價值[J];中國醫(yī)學影像學雜志;2006年02期

6 熊益敏,方慶和,馬佩炯,許垂豐,王文獻;毛刺征對肺孤立結節(jié)的診斷價值[J];影像診斷與介入放射學;2004年04期

7 高向濤,林大全,顏海嬰,王江;中國人仿真頭頸部體模的解剖參數(shù)及CT值研究[J];中華放射醫(yī)學與防護雜志;1998年06期

相關碩士學位論文 前2條

1 李鋒坦;CT掃描中管電壓對輻射劑量和CT值及灌注結果的影響[D];天津醫(yī)科大學;2010年

2 李明君;周圍型小肺癌毛刺的病理學檢查對靶區(qū)勾畫的意義[D];青島大學;2009年

，

本文編號：1814346