本文選題：失神發(fā)作 + 特發(fā)性全面性癲癇��； 參考：《新鄉(xiāng)醫(yī)學(xué)院》2014年碩士論文

【摘要】：背景 特發(fā)性全面性癲癇(Idiopathic Generalized Epilepsy, IGE)是一組癲癇綜合征的統(tǒng)稱,伴有典型失神發(fā)作的IGE是較特殊的一類疾病,突出的特點(diǎn)是突發(fā)突止的意識(shí)障礙,表現(xiàn)為突然停止正在進(jìn)行的動(dòng)作,旁人呼叫不可應(yīng)答,持續(xù)時(shí)間數(shù)秒至數(shù)十秒不等,之后繼續(xù)發(fā)作前正在進(jìn)行的動(dòng)作,腦電圖極具特征性,表現(xiàn)為雙側(cè)對(duì)稱同步的3Hz棘慢波�；隗w素的形態(tài)測(cè)量學(xué)分析(voxel-based morphometry, VBM)是一種磁共振的結(jié)構(gòu)分析法,可觀察腦組織的細(xì)微改變,伴有典型失神發(fā)作的IGE的腦組織改變有何特點(diǎn),一直沒有確切的答案。 目的 觀察伴有典型失神發(fā)作的特發(fā)性全面性癲癇患者腦灰質(zhì)體積改變有何特點(diǎn)。 方法 收集9例常規(guī)頭顱磁共振無(wú)異常的伴有典型失神發(fā)作的IGE患者和16例年齡、性別組成相匹配的正常志愿者,使用3.0T磁共振進(jìn)行全腦結(jié)構(gòu)(3D)掃描,采用VBM方法對(duì)腦灰質(zhì)體積進(jìn)行分析,觀察其灰質(zhì)體積改變有何特點(diǎn)。 結(jié)果 與正常對(duì)照組相比,伴有典型失神發(fā)作的IGE患者存在廣泛的腦灰質(zhì)體積減小,包括以下13個(gè)區(qū)域：右側(cè)額葉直回、左側(cè)額葉直回、右側(cè)距狀回/楔葉/舌回/枕中回/枕下回、左側(cè)枕葉舌回/枕下回、左側(cè)顳中回/顳上回、左側(cè)枕下回/舌回、右側(cè)枕葉舌回、左側(cè)枕中回、右側(cè)枕中回/枕上回/顳中回、右側(cè)楔前葉/楔葉、右側(cè)頂上小葉、右側(cè)中央前回、右側(cè)額上回/旁中央小葉/補(bǔ)充運(yùn)動(dòng)區(qū),未發(fā)現(xiàn)灰質(zhì)體積增大的腦區(qū)。 結(jié)論伴有典型失神發(fā)作的IGE患者存在廣泛的腦灰質(zhì)體積減小,其中以枕葉最為顯著。
[Abstract]:Background Idiopathic Generalized Epilepsys (ige) is a group of epilepsy syndromes. IGE with typical apnesia is a special kind of disease, which is characterized by sudden and sudden disturbance of consciousness. The call can not be answered and lasts from several seconds to tens of seconds. After that, the EEG is characterized by bilateral symmetrical synchronous 3Hz spike and slow wave. Morphometric analysis based on voxel-based morphometry (VBM) is a structural analysis of magnetic resonance, which can observe the subtle changes of brain tissue and the characteristics of brain tissue changes in IGE with typical aphasia. There is no definite answer. Purpose To observe the characteristics of gray matter volume changes in idiopathic comprehensive epilepsy with typical aphasia. Method A total of 9 IGE patients with typical aphasia and 16 normal volunteers with matched age and sex were examined with 3.0T MRI. The changes of gray matter volume were analyzed by VBM method. Result Compared with the normal control group, IGE patients with typical aphasia had extensive reduction of gray matter volume, including the following 13 regions: right frontal gyrus, left frontal gyrus, right distal gyrus / cuneiform gyrus / lingual gyrus / middle occipital gyrus / suboccipital gyrus. Left occipital gyrus / inferior occipital gyrus, left middle temporal / superior temporal gyrus, left inferior occipital / lingual gyrus, right occipital lobe lingual gyrus, left occipital middle gyrus, right middle occipital / superior occipital / middle temporal gyrus, right anterior cuneate / cuneate lobe, right superior parietal lobule, In the right precentral gyrus, right superior frontal gyrus / paraspinal central lobule / supplementary motor area, no enlarged gray matter area was found. Conclusion extensive reduction of gray matter volume was found in IGE patients with typical aphasia, especially in occipital lobe.
【學(xué)位授予單位】：新鄉(xiāng)醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R742.1

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