本文選題：經(jīng)顱磁刺激 + 抗癲癇藥物　； 參考：《浙江大學(xué)》2014年碩士論文

【摘要】：目的： 利用單脈沖經(jīng)顱磁刺激(Transcranial magnetic stimulation, TMS)技術(shù)來(lái)研究抗癲癇藥物對(duì)癲癇患者大腦皮質(zhì)興奮性和抑制性的影響作用,并尋找早期評(píng)價(jià)抗癲癇藥物療效的客觀指標(biāo)。 方法： 對(duì)40例新診斷癲癇的患者在服用抗癲癇藥物單藥治療前行經(jīng)顱磁刺激測(cè)定并記錄雙側(cè)大腦的靜息期運(yùn)動(dòng)皮質(zhì)閾值(rest motor threshold, rMT),并在堅(jiān)持規(guī)律服用抗癲癇藥物2-3月時(shí)再次行經(jīng)顱磁刺激測(cè)定并記錄雙側(cè)大腦的靜息期運(yùn)動(dòng)皮質(zhì)閾值。對(duì)比癲癇患者服藥前后靜息期運(yùn)動(dòng)皮質(zhì)閾值。 結(jié)果： 40例新診斷癲癇患者服藥前的右側(cè)大腦運(yùn)動(dòng)皮質(zhì)閾值為52.5±9.3,左側(cè)為49.8±8.4,服藥2-3月后右側(cè)大腦運(yùn)動(dòng)皮質(zhì)閾值升至57.2±9.0,左側(cè)升至55.2±7.2,服藥前后左右側(cè)運(yùn)動(dòng)皮質(zhì)閾值升高都具有顯著統(tǒng)計(jì)學(xué)意義(P0.05)。其中服用奧卡西平26例,服藥前右側(cè)MT是52.9±8.4,左側(cè)MT是50.6±8.4,服藥后右側(cè)MT是58.1±8.7,左側(cè)55.7±8.0,服藥前后左右側(cè)對(duì)比均有統(tǒng)計(jì)學(xué)意義。根據(jù)抗癲癇藥物療效分組,癲癇控制總有效組治療前后左右側(cè)大腦MT變化有統(tǒng)計(jì)學(xué)意義,而癲癇控制無(wú)效組治療前后左右側(cè)大腦MT變化無(wú)統(tǒng)計(jì)學(xué)意義。 結(jié)論： 抗癲癇藥物如奧卡西平能顯著提升患者大腦皮質(zhì)運(yùn)動(dòng)閾值,降低大腦運(yùn)動(dòng)皮質(zhì)興奮性,減少癲癇發(fā)作頻率,可能與細(xì)胞膜鈉離子通道阻滯有關(guān)。TMS能作為早期客觀地評(píng)估抗癲癇藥物療效的有效工具。
[Abstract]:Objective:The effects of antiepileptic drugs on the excitability and inhibition of cerebral cortex of epileptic patients were studied by transcranial magnetic stimulation (TMS) technique, and the objective indexes for early evaluation of antiepileptic effects were found.Methods:In 40 newly diagnosed epileptic patients, transcranial magnetic stimulation (TMS) was used to measure and record the resting phase motor cortex threshold (rest motor threshold, rMTT) of bilateral cerebrum before taking antiepileptic drugs alone, and then to take antiepileptic drugs on a regular basis for 2-3 months.Transcranial magnetic stimulation (TMS) was performed to measure and record the resting motor cortex threshold of bilateral cerebrum.To compare the threshold of motor cortex before and after taking medicine in epileptic patients.Results:The threshold of right cerebral motor cortex and left side were 52.5 鹵9.3 and 49.8 鹵8.4 before medication in 40 newly diagnosed epileptic patients. After 2-3 months, the threshold of right cerebral motor cortex rose to 57.2 鹵9.0 and 55.2 鹵7.2 to 55.2 鹵7.2 respectively. The threshold of left and right motor cortex increased before and after taking medicine.There was significant statistical significance (P 0.05).Twenty-six patients were treated with oxcarbazepine, the right MT was 52.9 鹵8.4, the left MT was 50.6 鹵8.4, the right MT was 58.1 鹵8.7, and the left 55.7 鹵8.0.According to the therapeutic effect of antiepileptic drugs, the changes of MT in left and right brain were statistically significant before and after treatment in the total effective group of epilepsy control, but there was no significant difference between the control group and the control group before and after treatment.Conclusion:Antiepileptic drugs such as oxcarbazepine can significantly increase the cerebral cortex motor threshold, reduce the excitability of the cerebral motor cortex, and reduce the frequency of epileptic seizures.TMS may be associated with cell membrane sodium channel arrest as an effective tool for early and objective evaluation of antiepileptic drug efficacy.
【學(xué)位授予單位】：浙江大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R742.1

【共引文獻(xiàn)】

相關(guān)期刊論文 前4條

1 楊云鳳;吳碧華;;磁刺激對(duì)體外原代神經(jīng)元遷移的影響[J];南昌大學(xué)學(xué)報(bào)(醫(yī)學(xué)版);2014年02期

2 劉玲;劉海波;王曉玲;孔麗;顧永盛;陳光輝;楊f ;;重復(fù)經(jīng)顱磁刺激治療卒中后吞咽功能障礙的系統(tǒng)文獻(xiàn)回顧[J];中國(guó)腦血管病雜志;2014年05期

3 曹莉;袁良津;陳祚勝;施雪英;謝丹丹;王雷;江偉;劉玉玲;;重復(fù)經(jīng)顱磁刺激對(duì)腦梗死患者運(yùn)動(dòng)功能恢復(fù)的影響[J];中國(guó)臨床保健雜志;2014年04期

4 Francesco Brigo;Stanley Chidi Igwe;;Meta-analyses in the wonderl and of neurology[J];World Journal of Meta-Analysis;2013年01期

相關(guān)博士學(xué)位論文 前6條

1 馮書(shū)芳;重復(fù)經(jīng)顱磁刺激對(duì)抑郁癥和精神分裂癥模型動(dòng)物的效應(yīng)和機(jī)制研究[D];第四軍醫(yī)大學(xué);2013年

2 伍炯星;甘露醇對(duì)GABA介導(dǎo)的抗癇作用機(jī)制研究[D];中南大學(xué);2013年

3 Isaac Dadzie;[D];江蘇大學(xué);2013年

4 王琳;重復(fù)經(jīng)顱磁刺激對(duì)局灶型肌張力障礙的治療研究[D];北京協(xié)和醫(yī)學(xué)院;2014年

5 徐琳;一漢族良性成人家族性肌陣攣癲癇家系的結(jié)構(gòu)磁共振研究[D];中南大學(xué);2014年

6 劉帥;癲癇相關(guān)突變鈉通道的電生理特性及其對(duì)蛋白激酶調(diào)控反應(yīng)性改變的研究[D];復(fù)旦大學(xué);2011年

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本文編號(hào)：1744546