本文選題：依達(dá)拉奉 + 丹紅注射液��； 參考：《中華中醫(yī)藥雜志》2017年11期

【摘要】：目的:評價依達(dá)拉奉聯(lián)合丹紅注射液對急性腦梗死(ACI)大鼠的療效和安全性。方法:將SD大鼠隨機(jī)分為假手術(shù)組、模型組、依達(dá)拉奉組、丹紅注射液組、依達(dá)拉奉聯(lián)合丹紅注射液組(聯(lián)合用藥組),采用線栓法制作大鼠左側(cè)大腦中動脈腦缺血(MCAO)模型,除假手術(shù)組外,每組按不同時間點(1、3、5、7d)分為4個亞組,觀察比較各組大鼠各時相的療效評價指標(biāo)(神經(jīng)功能缺損評分、腦組織梗死體積、腦組織含水量、腦組織形態(tài)學(xué)改變)及安全性評價指標(biāo)。結(jié)果:與模型組比較,假手術(shù)組各項療效評價指標(biāo)數(shù)值均存在顯著差異(P0.05,P0.01);與其他用藥組比較,模型組各項療效評價指標(biāo)及部分安全性評價指標(biāo)數(shù)值均存在顯著差異(P0.05,P0.01);依達(dá)拉奉組與丹紅組比較,各項療效評價指標(biāo)及安全性指標(biāo)數(shù)值無顯著差異;各單藥組與聯(lián)合用藥組比較,各項療效指標(biāo)數(shù)值存在顯著性差異(P0.05),尤以聯(lián)合用藥組第5、7天差異最為顯著(P0.01)。結(jié)論:依達(dá)拉奉聯(lián)合丹紅注射液治療ACI療效優(yōu)于單用依達(dá)拉奉或丹紅注射液,且治療效果可靠安全,并且隨治療時間延長,對腦梗死的改善作用越明顯。
[Abstract]:Objective: to evaluate the efficacy and safety of Edaravone combined with Danhong injection in acute cerebral infarction (ACI) rats.Methods: SD rats were randomly divided into sham-operation group, model group, Edaravone group, Dan Hong injection group and Edaravone combined with Danhong injection group.In addition to sham operation group, each group was divided into 4 subgroups according to different time points for 5 days. The evaluation indexes (neurological deficit score, cerebral infarct volume, water content of brain tissue) were observed and compared in each group.Brain histomorphology) and safety evaluation index.Results: compared with the model group, there were significant differences between the sham-operation group and the other groups.There were significant differences in the value of each curative effect evaluation index and part of safety evaluation index between the model group and the Edaravone group, but there was no significant difference between the Edaravone group and the Dan Hong group.There was significant difference between each single drug group and the combined treatment group, especially in the combined treatment group on the 7th day (P 0.01).Conclusion: Edaravone combined with Danhong injection is superior to Edaravone or Danhong injection in the treatment of ACI, and the effect of Edaravone and Danhong injection is reliable and safe, and the improvement of cerebral infarction is more obvious with the prolongation of treatment time.
【作者單位】： 湖南中醫(yī)藥大學(xué);湖南中醫(yī)藥大學(xué)第一附屬醫(yī)院;
【基金】：湖南省科技廳重點項目(No.2014SK2007)~~
【分類號】：R743.33

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