本文選題：腦梗死　切入點：靜脈溶栓　出處：《中國醫(yī)科大學(xué)學(xué)報》2017年12期

【摘要】：目的探討急性腦梗死患者靜脈輸注重組組織型纖溶酶原激活劑(rt-PA)后出血性轉(zhuǎn)化的相關(guān)危險因素。方法采用病例-對照研究的方法,選取21例急性腦梗死接受rt-PA靜脈溶栓治療后出現(xiàn)腦出血性轉(zhuǎn)化者為病例組,并選擇同一時期63例急性腦梗死接受rt-PA靜脈溶栓治療后未發(fā)生腦出血性轉(zhuǎn)化者為對照組。應(yīng)用單因素及多因素logistic回歸分析溶栓后出血性轉(zhuǎn)化的相關(guān)危險因素。結(jié)果單因素分析結(jié)果顯示,病例組中溶栓前美國國立衛(wèi)生院卒中量表(NIHSS)評分10分、高血壓(溶栓前收縮壓≥140 mmHg)、溶栓前血糖值升高、具有心房顫動史和腦血管疾病史的比例顯著高于對照組。多因素logistic回歸分析結(jié)果顯示,溶栓前收縮壓≥140 mmHg(OR=14.59,95%CI:1.63~130.95)、溶栓前血糖值升高(OR=9.92,95%CI:0.97~101.24)以及具有腦血管疾病史(OR=10.75,95%CI:1.76~65.78)是急性腦梗死患者接受rt-PA靜脈溶栓后出血性轉(zhuǎn)化的危險因素。結(jié)論溶栓前收縮壓≥140 mmHg、溶栓前血糖值升高以及具有腦血管疾病史是急性腦梗死患者接受rt-PA靜脈溶栓后出血性轉(zhuǎn)化的危險因素。
[Abstract]:Objective to investigate the risk factors of hemorrhagic transformation after intravenous infusion of recombinant tissue plasminogen activator (rt-PA) in patients with acute cerebral infarction.Methods A case-control study was conducted in 21 patients with acute cerebral infarction who underwent intravenous thrombolytic therapy with rt-PA.63 patients with acute cerebral infarction received intravenous thrombolytic therapy with rt-PA were selected as control group.Univariate and multivariate logistic regression analysis was used to analyze the risk factors of hemorrhagic transformation after thrombolysis.Results the results of univariate analysis showed that the stroke scale of the National Institutes of Health before thrombolysis was 10 points, hypertension (systolic pressure before thrombolysis 鈮，

本文編號：1701857