本文選題：腦卒中　切入點(diǎn)：缺血性腦卒中　出處：《山東醫(yī)藥》2017年31期

【摘要】：目的觀察尿激酶靜脈溶栓治療急性輕型缺血性腦卒中的療效。方法將90例發(fā)病6 h內(nèi)的急性輕型缺血性腦卒中患者隨機(jī)分為觀察組40例和對(duì)照組50例。觀察組患者入院后給予尿激酶100萬單位溶于200 mL生理鹽水中靜滴,24 h后復(fù)查頭顱影像學(xué)排除腦出血,然后給予阿司匹林100 mg/d長(zhǎng)期口服治療。對(duì)照組患者入院后立即給予阿司匹林100 mg/d長(zhǎng)期口服治療。記錄兩組患者治療前、治療后14 d的美國(guó)國(guó)立衛(wèi)生院卒中量表評(píng)分(NIHSS評(píng)分)及治療后90 d NIHSS評(píng)分≤1分患者例數(shù)、改良Rankin量表評(píng)分(mRS評(píng)分)≤2分患者例數(shù),另記錄兩組治療后90 d內(nèi)癥狀性顱內(nèi)出血(SICH)、復(fù)發(fā)及死亡情況。結(jié)果觀察組治療前、治療14 d后NIHSS評(píng)分分別為(2.94±0.60)、(1.6±0.92)分,對(duì)照組分別為(2.97±0.73)、(2.17±0.53),兩組治療14 d后NIHSS評(píng)分均低于治療前,且治療14 d后觀察組NIHSS評(píng)分低于對(duì)照組(P均0.05)。治療后90 d觀察組NIHSS評(píng)分≤1分31例(77.5%),mRS評(píng)分≤2分32例(80%);對(duì)照組分別為23例(46%)和27例(54%);治療后90 d觀察組NIHSS評(píng)分≤1分者、mRS評(píng)分≤2分者均高于對(duì)照組(P均0.05)。治療后90 d內(nèi)兩組均無SICH、死亡者;觀察組2例(5.0%)、對(duì)照組9例(18%)復(fù)發(fā),兩組比較,P0.05。結(jié)論尿激酶靜脈溶栓治療急性輕型缺血性腦卒中有效,并且可以減少卒中的復(fù)發(fā)。
[Abstract]:Objective to observe the efficacy of intravenous thrombolysis with urokinase in the treatment of acute mild ischemic stroke. Methods 90 patients with acute mild ischemic stroke within 6 hours were randomly divided into observation group (n = 40) and control group (n = 50). Patients were treated with urokinase 1 million units dissolved in 200ml saline for 24 hours. The patients in the control group were treated with aspirin for a long period of time immediately after admission. The patients in both groups were recorded before treatment. The number of patients with National Institutes of Health Stroke scale (NHS) and 90 days after treatment (NIHSS score 鈮，

本文編號(hào)：1681937