本文選題：腦小血管病　切入點：腎小球濾過率　出處：《中國現(xiàn)代醫(yī)學雜志》2017年14期

【摘要】：目的 探討腦小血管病(CSVD)患者的腎小球濾過率(GFR)和尿微量白蛋白(m ALB)水平與認知損害的關系。方法 選取84例CSVD患者(CSVD組)和50例健康體檢者(對照組)為研究對象,測定患者的生化指標和m ALB,計算GFR,分析GFR和m ALB與認知損害的相關性。結(jié)果 CSVD組的GFR、尿微量白蛋白陽性率與對照組比較,差異無統(tǒng)計學意義(P0.05),CSVD組的GFR水平低于對照組,尿微量白蛋白水平則高于對照組;CSVD患者GFR陽性組的Mo CA評分低于GFR陰性組,合并VCI發(fā)生率則高于GFR陰性組;CSVD患者尿微量白蛋白陽性組的Mo CA評分低于尿微量白蛋白陰性組,合并VCI發(fā)生率則高于尿微量白蛋白陰性組。結(jié)論 CSVD合并GFR及m ALB水平異常的患者均存在不同程度認知功能障礙,GFR及m ALB水平異�？赡軈⑴cCSVD認知功能損害的發(fā)病過程,GFR和m ALB的檢測對于CSVD合并認知功能損害的早期篩查具有重要意義。
[Abstract]:Objective to investigate the relationship between glomerular filtration rate (GFR) and urinary albumin (Alb) levels and cognitive impairment in patients with small cerebral vascular disease (CSVD). Methods 84 patients with CSVD and 50 healthy controls were selected as subjects. The correlation between GFR and m ALB and cognitive impairment was analyzed. Results compared with the control group, the positive rate of urinary microalbumin in the CSVD group was lower than that in the control group, and the GFR level in the CSVD group was lower than that in the control group. The level of urinary microalbumin was higher in GFR positive group than that in GFR negative group, and the incidence of VCI was higher in GFR negative group than that in GFR negative group. The incidence of VCI in patients with VCI was higher than that in patients with negative urinary microalbumin.Conclusion the abnormal levels of GFR and m ALB in patients with CSVD and abnormal GFR and m ALB levels may be involved in the development of cognitive impairment of CSVD. The detection of GFR and m ALB plays an important role in the early screening of CSVD with cognitive impairment.
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本文編號：1671867