本文選題：甘露醇　切入點(diǎn)：地塞米松　出處：《中國(guó)藥房》2017年24期

【摘要】：目的:探討甘露醇聯(lián)合地塞米松對(duì)感染性腦水腫患者相關(guān)指標(biāo)的影響。方法:回顧性分析120例感染性腦水腫患者資料,按治療方案的不同分為對(duì)照組(60例)和觀察組(60例)。對(duì)照組患者給予呋塞米注射液20 mg+20%甘露醇注射液1 g/(kg·次)+0.9%氯化鈉注射液10 mL,靜脈滴注,每6 h 1次,用藥3 d后視患者病情調(diào)整劑量。觀察組患者給予地塞米松磷酸鈉注射液10～20 mg+20%甘露醇注射液1 g/(kg·次)+0.9%氯化鈉注射液10 mL,靜脈滴注,每6 h 1次,用藥3 d后視患者病情調(diào)整劑量。兩組均以7 d為1個(gè)療程,共治療2個(gè)療程。觀察兩組患者治療前后一氧化氮(NO)、白細(xì)胞介素1(IL-1)、腫瘤壞死因子α(TNF-α)水平,病死率、后遺癥及不良反應(yīng)發(fā)生情況。結(jié)果:治療前,兩組患者NO、IL-1、TNF-α水平比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療后,兩組患者NO、IL-1、TNF-α水平均顯著低于同組治療前,且觀察組顯著低于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。觀察組患者病死率、后遺癥及不良反應(yīng)發(fā)生率均顯著低于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:甘露醇聯(lián)合地塞米松能降低感染性腦水腫患者的炎癥因子水平、后遺癥發(fā)生率及病死率,且未增加不良反應(yīng)的發(fā)生。
[Abstract]:Objective: to investigate the effect of mannitol combined with dexamethasone on the related indexes in patients with infectious brain edema. The patients in the control group were given furosemide injection 20 mg 20% mannitol for 1 g/(kg) 0.9% sodium chloride injection 10 mL intravenous drip once every 6 h, and the control group was divided into two groups according to the different treatment schemes: control group (n = 60) and observation group (n = 60). The patients in the control group were given furosemide injection 20 mg 20% mannitol (1 g/(kg). The patients in the observation group were treated with dexamethasone sodium phosphate injection 10 ~ 20 mg 20% mannitol (1 g/(kg), 0.9% sodium chloride injection 10 mL, intravenous drip once every 6 h, after 3 days of treatment, the patients in the observation group were given dexamethasone sodium phosphate injection (10 mg 20% mannitol injection 1 g/(kg). The patients in both groups were treated with 7 days as a course of treatment for 2 courses of treatment. The levels of nitric oxide (no), interleukin 1 (IL 1), tumor necrosis factor 偽 (TNF- 偽), and mortality were observed before and after treatment. Results: there was no significant difference in the levels of NOIL-1TNF- 偽 between the two groups before treatment. After treatment, the levels of NOIL-1TNF- 偽 in the two groups were significantly lower than those in the same group, and the levels of TNF- 偽 in the observation group were significantly lower than those in the control group. The mortality, sequelae and adverse reactions in the observation group were significantly lower than those in the control group. Conclusion: mannitol combined with dexamethasone can reduce the levels of inflammatory factors, sequelae and mortality in patients with infective brain edema, and does not increase the incidence of adverse reactions.
【作者單位】： 南陽(yáng)市中心醫(yī)院/鄭州大學(xué)附屬南陽(yáng)醫(yī)院感染性疾病科;南陽(yáng)醫(yī)學(xué)高等專(zhuān)科學(xué)�；A(chǔ)醫(yī)學(xué)部;
【分類(lèi)號(hào)】：R742
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本文編號(hào)：1666176