本文選題：視神經(jīng)脊髓炎譜系疾病　切入點(diǎn)：白介素-36α　出處：《吉林大學(xué)》2017年碩士論文

【摘要】：目的:本研究旨在分析比較NMOSD患者與ONNDs組患者血清及腦脊液IL-36α表達(dá)及臨床意義,并探討其與NMOSD疾病嚴(yán)重程度的相關(guān)性,為揭示NMOSD的發(fā)病機(jī)制及尋求治療靶點(diǎn)提供新的思路和方向。對(duì)象與方法:選取2015年1月至2016年8月之間就診于吉林大學(xué)第一醫(yī)院神經(jīng)內(nèi)科住院部的NMOSD患者73例,男性14例,女性59例。所有入組患者按最新NMOSD診斷標(biāo)準(zhǔn)經(jīng)兩位神經(jīng)免疫專業(yè)醫(yī)生診斷,均為臨床確診病例,并對(duì)入選患者進(jìn)行擴(kuò)展殘疾狀態(tài)量表(expanded disability status scale,EDSS)來判斷神經(jīng)功能缺損程度。同時(shí)選取性別、年齡匹配的ONNDs組患者50例。所有患者在樣本采集前3個(gè)月內(nèi)均未接受激素及免疫抑制劑治療。所有患者均經(jīng)本人及家屬同意并簽署知情同意書。1.雙抗體夾心酶聯(lián)免疫吸附方法(enzyme linked immunosorbent assay,ELISA)檢測(cè)NMOSD患者血清及腦脊液中IL-36α的水平。2.分析血清及腦脊液中IL-36α的水平與NMOSD患者EDSS評(píng)分及年復(fù)發(fā)率(annualized relapse rate,ARR)的相關(guān)性。結(jié)果:1.NMOSD患者血清及腦脊液中IL-36α的水平較ONNDs組患者明顯增高,差異有統(tǒng)計(jì)學(xué)意義(p=0.0335,p=0.0003)。2.NMOSD患者血清及腦脊液中IL-36α的水平與EDSS呈正相關(guān)(p=0.0412,p=0.0064);與ARR無明顯相關(guān)性(p=0.4497,p=0.5473)。結(jié)論:NMOSD患者血清及腦脊液中IL-36α的水平較ONNDs組患者明顯增高,提示促炎作用的細(xì)胞因子IL-36α可能在NMOSD的致病過程中發(fā)揮作用。NMOSD患者血清及腦脊液中IL-36α的水平與EDSS呈正相關(guān),提示IL-36α可能成為評(píng)估NMOSD疾病嚴(yán)重程度的新的生物標(biāo)志物。
[Abstract]:Objective: to analyze and compare the expression and clinical significance of IL-36 偽 in serum and cerebrospinal fluid (CSF) of patients with NMOSD and ONNDs, and to explore the relationship between IL-36 偽 expression and the severity of NMOSD. In order to reveal the pathogenesis of NMOSD and provide new ideas and directions for seeking therapeutic targets, 73 NMOSD patients, 14 males, were selected from January 2015 to August 2016 in Department of Neurology, first Hospital of Jilin University. 59 cases of female. All the patients in the group were diagnosed by two neuroimmunologists according to the latest diagnostic criteria of NMOSD, all of them were clinically confirmed cases. The selected patients were evaluated with expanded disability status scale EDSSs to determine the degree of neurological impairment. At the same time, gender was selected. All the patients were not treated with hormone and immunosuppressant within 3 months before sampling. All patients received informed consent form with the consent of themselves and their families. 1. Double antibody sandwich enzyme link. The level of IL-36 偽 in serum and cerebrospinal fluid (CSF) of NMOSD patients was detected by linked immunosorbent Elisa. 2. The correlation between IL-36 偽 level in serum and cerebrospinal fluid and EDSS score and annual recurrence rate of NMOSD patients was analyzed. The level of IL-36 偽 in liquid was significantly higher than that in ONNDs group. The level of IL-36 偽 in serum and cerebrospinal fluid was positively correlated with EDSS and had no significant correlation with ARR. Conclusion the level of IL-36 偽 in serum and cerebrospinal fluid of ONNDs patients was significantly higher than that in ONNDs group. The results suggest that IL-36 偽, the cytokine of proinflammatory effect, may play a role in the pathogenesis of NMOSD. The level of IL-36 偽 in serum and cerebrospinal fluid of NMOSD patients is positively correlated with EDSS, suggesting that IL-36 偽 may be a new biomarker for evaluating the severity of NMOSD disease.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R744.52

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