本文選題：神經(jīng)元特異性烯醇化酶　切入點(diǎn)：中國(guó)缺血性卒中亞型　出處：《浙江實(shí)用醫(yī)學(xué)》2016年05期

【摘要】：目的探討不同CISS分型的急性腦梗死患者血清神經(jīng)元特異性烯醇化酶(NSE)表達(dá)水平的臨床意義。方法通過(guò)CISS分型將106例急性腦梗死患者分成不同亞組,進(jìn)行NIHSS評(píng)分,并測(cè)定血清NSE水平,另選擇99例體檢健康者作為對(duì)照組,分析各亞組之間NSE水平差異以及NSE與NIHSS評(píng)分之間的關(guān)系。結(jié)果血清NSE含量以心源性腦梗死(CS)型最高,其次為不明原因性腦梗死(UND)型、其他病因明確性腦梗死(OE)型及大動(dòng)脈粥樣硬化性腦梗死(LAA)型,穿支動(dòng)脈閉塞性腦梗死(PAD)型最低,而NIHSS評(píng)分亦以CS型最高,其次為L(zhǎng)AA型、UND型及OE型,PAD型最低,與臨床高度一致,血清NSE水平與NIHSS評(píng)分呈正相關(guān)(r=0.463,P0.01)。結(jié)論血清NSE水平能夠反映不同病因腦梗死的病情嚴(yán)重程度,可以作為評(píng)估急性腦梗死病情和預(yù)后的簡(jiǎn)便敏感的血清學(xué)指標(biāo)之一,與NIHSS評(píng)分相結(jié)合,結(jié)果更可靠。
[Abstract]:Objective to investigate the clinical significance of serum neuron-specific enolase (NSE) expression in patients with acute cerebral infarction according to different CISS classification. Methods 106 patients with acute cerebral infarction were divided into different subgroups by CISS classification and NIHSS scores were evaluated. Serum NSE levels were measured and 99 healthy persons were selected as control group. The difference of NSE level and the relationship between NSE and NIHSS score were analyzed. Results the serum NSE level was the highest in patients with cardiogenic cerebral infarction. The second type was unexplained cerebral infarction (NIHSS), the other type of definite cerebral infarction (OE), the type of atherosclerotic cerebral infarction (ACI) and the type of arteriosclerotic cerebral infarction (ICA) were the lowest, and the NIHSS score was the highest in type CS. Secondly, LAA type UND and OE type of pad type were the lowest, which was highly consistent with clinical data. Serum NSE level was positively correlated with NIHSS score (P 0.01). Conclusion Serum NSE level can reflect the severity of cerebral infarction with different etiological factors. It can be used as a simple and sensitive serological index to evaluate the condition and prognosis of acute cerebral infarction. Combined with NIHSS score, the result is more reliable.
【作者單位】： 嘉興市第一醫(yī)院;
【基金】：浙江省嘉興市醫(yī)學(xué)重點(diǎn)學(xué)科(神經(jīng)病學(xué))資助(04-F-12)
【分類(lèi)號(hào)】：R743.33

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