本文選題：成纖維細(xì)胞生長(zhǎng)因子　切入點(diǎn)：Klotho蛋白　出處：《中風(fēng)與神經(jīng)疾病雜志》2017年04期 　論文類型：期刊論文

【摘要】：目的探討血清成纖維細(xì)胞生長(zhǎng)因子23(FGF23)、Klotho蛋白水平與急性腦梗死患者頸動(dòng)脈粥樣硬化和腦卒中危險(xiǎn)因素的相關(guān)性。方法入選166例急性腦梗死患者作為研究組,隨機(jī)匹配152例健康為對(duì)照組,對(duì)血脂、同型半胱氨酸、C反應(yīng)蛋白等指標(biāo)進(jìn)行采集,采用ELISA法測(cè)定各組血清中FGF23和Klotho蛋白水平,頸動(dòng)脈As用多普勒超聲儀檢測(cè),并與正常對(duì)照組進(jìn)行比較。應(yīng)用多因素Logistic回歸對(duì)血清中FGF23水平與其他觀察指標(biāo)的相關(guān)性及影響因素進(jìn)行分析。結(jié)果研究組tHcy、hs-CRP、FGF23水平顯著高于對(duì)照組(P0.05),而HDL-C、Klotho蛋白水平顯著低于對(duì)照組(P0.05),TC、LDL-C、TG與對(duì)照組相比統(tǒng)計(jì)學(xué)差異不顯著(P0.05)。研究組的頸動(dòng)脈As的比率、斑塊數(shù)、斑塊評(píng)分及IMT顯著高于正常對(duì)照組(P0.05)。以頸動(dòng)脈As情況為因變量,進(jìn)行多因素非條件Logistic回歸分析顯示,hs-CRP、tHcy、FGF23為頸動(dòng)脈As的危險(xiǎn)因素,而HDL-C、Klotho蛋白為頸動(dòng)脈As的保護(hù)因素。相關(guān)性分析顯示,血FGF23水平與hs-CRP、tHcy、及頸動(dòng)脈As斑塊評(píng)分、IMT呈正相關(guān)(均P0.05);而與Klotho蛋白、HDL-C呈負(fù)相關(guān)(均P0.05)。結(jié)論 FGF23為動(dòng)脈粥樣硬化及腦梗死發(fā)生的危險(xiǎn)因素,而Klotho蛋白則為動(dòng)脈粥樣硬化及腦梗死發(fā)生的保護(hù)因素,二者呈負(fù)相關(guān)。
[Abstract]:Objective to investigate the relationship between serum fibroblast growth factor 23 FGF23 Klotho protein and carotid atherosclerosis and stroke risk factors in patients with acute cerebral infarction. Methods 166 patients with acute cerebral infarction were selected as the study group. Blood lipids and homocysteine C-reactive protein were collected. Serum FGF23 and Klotho protein levels were measured by ELISA method. Carotid artery as was detected by Doppler ultrasound. Multivariate Logistic regression was used to analyze the correlation between serum FGF23 level and other observed indexes and its influencing factors. Results the level of tHcyhs-CRPfGF23 in the study group was significantly higher than that in the control group (P 0.05), while the level of HDL-Cn Klotho protein in the study group was significantly higher than that in the control group. Compared with the control group, there was no significant difference in TG between the control group and the control group (P 0.05). The ratio of as in the carotid artery in the study group was significantly lower than that in the control group. Plaque number, plaque score and IMT were significantly higher than those in normal control group (P 0.05). Multivariate Logistic regression analysis showed that hs-CRPtHcyFGF23 was a risk factor for carotid as. HDL-Con Klotho protein was the protective factor of carotid as. Correlation analysis showed that, Serum FGF23 level was positively correlated with hs-CRPtHcyT and carotid as plaque score (all P0.05%), but negatively correlated with HDL-C of Klotho protein (all P0.050.Conclusion FGF23 is a risk factor for atherosclerosis and cerebral infarction. Klotho protein was the protective factor of atherosclerosis and cerebral infarction.
【作者單位】： 包頭醫(yī)學(xué)院第一附屬醫(yī)院神經(jīng)內(nèi)科;包頭醫(yī)學(xué)院研究生學(xué)院;
【分類號(hào)】：R743.33

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