本文選題：卒中　切入點：認知障礙　出處：《中國腦血管病雜志》2016年12期 　論文類型：期刊論文

【摘要】：目的探討大腦中動脈搏動指數(shù)與腔隙性腦梗死患者認知功能障礙之間的關(guān)系,為卒中后認知功能障礙提供更多早期診斷方法。方法回顧性連續(xù)納入2015年10月到2016年5月新疆軍區(qū)總醫(yī)院神經(jīng)內(nèi)科門診及住院的急性腔隙性腦梗死患者60例為腔梗組,同期行腦血管功能檢查無腦梗死的對照人群30例為對照組,所有患者進行基本信息采集及經(jīng)顱多普勒超聲檢查,記錄大腦中動脈搏動指數(shù),同時采用事件相關(guān)電位P300、畫鐘測驗、連線測驗A和B評價兩組患者認知功能并進行比較。結(jié)果腔梗組患者搏動指數(shù)較對照組增高(1.14±0.63比0.89±0.24),差異有統(tǒng)計學(xué)意義(P0.05);兩組認知功能比較,腔梗組較對照組事件相關(guān)電位潛伏期延長[(351±34)ms比(321±15)ms]、波幅降低[(5.0±1.4)μV比(7.9±2.6)μV],連線測驗A、B測試時間延長[(81±7)s比(64±8)s,(166±18)s比(105±25)s],差異均有統(tǒng)計學(xué)意義(均P0.05)。搏動指數(shù)與事件相關(guān)電位潛伏期和連線測驗A、B測試時長呈正相關(guān)(r分別為0.517、0.393、0.637;均P0.05),與事件相關(guān)電位波幅呈負相關(guān)(r=-0.324,P=0.007)。結(jié)論大腦中動脈搏動指數(shù)與腔隙性腦梗死患者的認知功能損害有關(guān),高搏動指數(shù)可提示一些認知域的障礙;經(jīng)顱多普勒超聲檢查可視為卒中后早期診斷認知功能障礙的輔助工具之一。
[Abstract]:Objective to investigate the relationship between middle cerebral artery pulsatility index and cognitive impairment in patients with lacunar infarction. Methods from October 2015 to May 2016, 60 patients with acute lacunar cerebral infarction who were admitted to the Department of Neurology, Department of Neurology, Xinjiang military region General Hospital were included as the lumen infarction group. 30 cases of control group without cerebral infarction underwent cerebrovascular function examination at the same time. All the patients underwent basic information collection and transcranial Doppler ultrasound examination to record the pulsatile index of middle cerebral artery. At the same time, the event-related potential (P300) was used to draw the clock test. Results compared with the control group, the pulsatile index of the two groups was 1.14 鹵0.63 vs 0.89 鹵0.24, the difference was statistically significant (P 0.05), the cognitive function of the two groups was higher than that of the control group. Compared with the control group, the latency of event-related potential was prolonged [351 鹵34 Ms vs 321 鹵15 Ms], the amplitude decreased [5.0 鹵1.4) 渭 V vs 7.9 鹵2.6 渭 V], and the test time of Aneb was prolonged [81 鹵7s vs 64 鹵8s vs 166 鹵18s vs 105 鹵25s], the difference was statistically significant (P 0.05). The positive correlation r was 0.517 ~ 0.393 ~ 0.637, respectively, and there was a negative correlation with the amplitude of event-related potential. Conclusion the pulsatility index of middle cerebral artery is related to cognitive impairment in patients with lacunar cerebral infarction, and it is negatively correlated with the amplitude of event-related potential (P < 0.05), which is negatively correlated with the amplitude of event-related potentials. Conclusion there is a significant correlation between the pulsatile index of middle cerebral artery and the cognitive impairment in patients with lacunar cerebral infarction. The high pulsatility index may indicate some cognitive domain disorders, and transcranial Doppler ultrasound can be regarded as one of the auxiliary tools for the early diagnosis of cognitive dysfunction after stroke.
【作者單位】： 新疆維吾爾自治區(qū)石河子大學(xué)醫(yī)學(xué)院;新疆軍區(qū)總醫(yī)院心內(nèi)科;新疆軍區(qū)總醫(yī)院神經(jīng)內(nèi)科;
【基金】：軍隊后勤科研計劃(CLJ16J006)
【分類號】：R743.33

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