本文選題：重離子　切入點(diǎn)：輻照　出處：《原子核物理評(píng)論》2017年02期 　論文類型：期刊論文

【摘要】：雖然重離子束治癌已經(jīng)被證明有著射程精確、入口坪區(qū)劑量小、相對(duì)生物學(xué)效應(yīng)高等顯著優(yōu)點(diǎn),但重離子輻照對(duì)腫瘤干細(xì)胞所產(chǎn)生的輻射生物學(xué)效應(yīng)特性依舊不明確。本研究使用人源神經(jīng)膠質(zhì)瘤干細(xì)胞來(lái)研究在面對(duì)腫瘤干細(xì)胞時(shí),重離子相對(duì)于傳統(tǒng)X射線是否有明顯的生物學(xué)優(yōu)勢(shì)。實(shí)驗(yàn)結(jié)果證明,在神經(jīng)膠質(zhì)瘤干細(xì)胞中,2 Gy碳離子造成的DNA損傷的修復(fù)率比X射線造成的損傷修復(fù)率要低;MTT實(shí)驗(yàn)則證明經(jīng)過(guò)碳離子輻照的腫瘤干細(xì)胞活力要比X射線輻照的腫瘤干細(xì)胞低得多。綜上所述,面對(duì)神經(jīng)膠質(zhì)瘤干細(xì)胞,碳離子能更有效地靶向腫瘤干細(xì)胞從而相對(duì)于傳統(tǒng)X射線有明顯的生物學(xué)優(yōu)勢(shì)。這些發(fā)現(xiàn)對(duì)于更好地理解重離子束治癌相關(guān)的生物學(xué)效應(yīng)有重要的作用。
[Abstract]:Although the treatment of cancer by heavy ion beam has been proved to have a precise range, a small dose at the entrance plateau, and a significant advantage over the biological effect, However, the radiobiological effects of heavy ion irradiation on tumor stem cells are still unclear. In this study, human glioma stem cells were used to study tumor stem cells. Whether heavy ions have obvious biological advantages over conventional X-ray. The repair rate of DNA damage caused by 2 Gy carbon ion in glioma stem cells is lower than that caused by X-ray. Stem cells are much lower. To sum up, In the face of glioma stem cells, Carbon ions can target tumor stem cells more effectively and thus have obvious biological advantages over conventional X-ray. These findings play an important role in better understanding the biological effects of heavy ion beam therapy on cancer.
【作者單位】： 中國(guó)科學(xué)院近代物理研究所空間輻射生物學(xué)實(shí)驗(yàn)室;中國(guó)科學(xué)院大學(xué);中國(guó)科學(xué)院昆明動(dòng)物研究所動(dòng)物模型與人類疾病機(jī)理重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金資助項(xiàng)目(31270895,U1232125,31400723,11335011)~~
【分類號(hào)】：R739.4

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8 戴捷,于\，

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