本文選題：中風(fēng)后痙攣性偏癱　切入點(diǎn)：解痙合劑　出處：《浙江中醫(yī)藥大學(xué)》2014年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的：本課題通過(guò)臨床研究,觀(guān)察解痙合劑聯(lián)合鹽酸替扎尼定片治療中風(fēng)后痙攣性偏癱 的臨床治療效果,為治療本病提供有效安全新方法。方法：按照納入標(biāo)準(zhǔn)選擇中風(fēng)后痙攣性偏癱患者110例,根據(jù)隨機(jī)數(shù)字表法分為治療組 1治療組2治療組3,3組均給予常規(guī)的神經(jīng)內(nèi)科及康復(fù)科治療；治療組1：給予加用鹽 酸替扎尼定片,同時(shí)每天用解痙合劑內(nèi)服外用。治療組2：給予加用鹽酸替扎尼定片。 治療組3：給予加用解痙合劑內(nèi)服外用。解痙合劑成分及用法：生白芍20克,炙甘草 10克,望江南20克,木瓜15克,乳香6克,沒(méi)藥6克,全蝎3克,丹參15克等；所 用中藥均為標(biāo)準(zhǔn)湯劑200毫升。服用方法：每日1劑,分早晚兩次口服,同時(shí)用上方浸 入500毫升的黃酒(酒精度13%v/v)中泡5天后再加熱煎取藥液300毫升做為外用藥液 (由本院藥劑科統(tǒng)一制作)涂擦痙攣肌群每日2次；鹽酸替扎尼定片用法：2mg/次,3 次/日,每3天增加2mg,增加至4mg/次,3次/日維持治療。在治療前及治療4周后對(duì) 入組患者進(jìn)行改良Ashworth評(píng)分、Barthel指數(shù)評(píng)分、Fugl-Meyer評(píng)分,評(píng)分由研究 人員及康復(fù)治療師共同進(jìn)行。研究人員對(duì)資料進(jìn)行收集、記錄、保存和分析,貫徹單盲 原則。結(jié)果：1.經(jīng)治療1個(gè)療程后,經(jīng)配對(duì)t檢驗(yàn),與同組治療前相比,三組治療后肢體肌張 力、日常生活能力及運(yùn)動(dòng)功能都有顯著的統(tǒng)計(jì)學(xué)意義(P0.05)。2.在改良Ashworth評(píng) 分、Barthel指數(shù)評(píng)分、Fugl-Meyer評(píng)分上經(jīng)方差分析進(jìn)行兩兩比較,治療組1與治療 組2比較P0.05,差異有顯著統(tǒng)計(jì)學(xué)意義；治療組1與治療組3比較P0.05,差異有 顯著統(tǒng)計(jì)學(xué)意義；治療組2與治療組3比較P0.05,差異無(wú)統(tǒng)計(jì)學(xué)意義。結(jié)論：解痙合劑聯(lián)合鹽酸替扎尼定片治療中風(fēng)后痙攣性偏癱的臨床療效優(yōu)于單獨(dú)使用解 痙合劑或者鹽酸替扎尼定片。
[Abstract]:Objective: this topic through clinical research, observation of spastic hemiplegia after stroke treated with Tizanidine Hydrochloride Tablets spasmolytic mixture
To provide effective and safe method for treating this disease. Methods: according to the inclusion criteria, 110 patients with spastic hemiplegia after stroke were selected and divided into treatment group according to random number table.
1 in the treatment group 2 treatment group 3,3 group were given routine treatment and rehabilitation; treatment group 1: to increase the use of salt
Acid tizanidine tablets, and antispasmodics oral topical treatment group: 2. Use every day to increase the use of Tizanidine Hydrochloride Tablets.
The treatment group: 3 to increase the use of internal and external components and antispasmodics. Usage: antispasmodics TGP 20 grams Zhigancao.
Wang Jiangnan 10 grams, 20 grams, papaya 15 grams, 6 grams of frankincense, myrrh 6 grams, 3 grams of scorpion, Salvia 15 grams; the
Use Chinese medicine as the standard decoction of 200 milliliters. Take the method: 1 doses per day, two times in the morning and evening, two times, at the same time soaked with the upper part of the decoction.
In 500 milliliters of yellow wine (alcohol 13%v/v) after 5 days, reheating and decocting 300 milliliters for external use
(Department of pharmacy of our hospital made uniform) with spastic muscles 2 times a day; Tizanidine Hydrochloride Tablets usage: 2mg/, 3
Every 3 days, the increase of 2mg, increased to 4mg/, and 3 / day maintenance treatment. Before and after 4 weeks of treatment,
The improved Ashworth score, the Barthel index score, the Fugl-Meyer score, and the score of the patients were studied.
The staff and rehabilitative therapists work together. The researchers collect, record, preserve and analyze the data and carry out single blindness.
Results: 1. after 1 courses of treatment, the three groups were treated with paired t test, compared with the same group before treatment.
There were significant statistical significance (P0.05).2. in the improved Ashworth evaluation.
The score of the Barthel index and the Fugl-Meyer score were compared by the analysis of variance 22. The treatment group was 1 and the treatment was treated.
Group 2 compared P0.05, the difference has significant statistical significance, 1 in the treatment group and 3 in the treatment group, P0.05, there is a difference between the treatment group and the treatment group 3.
Statistical significance; treatment group 2 and treatment group 3 compared to P0.05, the difference was not statistically significant. Conclusion: the combined treatment of Tizanidine Hydrochloride Tablets spasmolytic mixture after stroke clinical curative effect of spastic hemiplegia alone solution
As agent or Tizanidine Hydrochloride Tablets.

【學(xué)位授予單位】：浙江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R743.3

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