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  本文選題：偏頭痛　切入點：卵圓孔未閉　出處：《吉林大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：研究目的：評價苯甲酸利扎曲普坦治療偏頭痛合并卵圓孔未閉的療效。 對象與方法：收集吉林大學(xué)白求恩第一醫(yī)院神經(jīng)內(nèi)科2013年5月到2013年12月發(fā)泡試驗檢查陽性偏頭痛患者113例為研究對象。隨機分為兩組，其中服用歐立停者為治療組，共55例，男15例，女40例，年齡平均36.5±11.14歲；服用抗偏頭痛常規(guī)用藥者為對照組，共58例，男16例，女42例，年齡平均36.2±11.11歲。治療組服用歐立停5mg，對照組服用抗偏頭痛常規(guī)藥1片，于頭痛發(fā)作開始時各服。觀察患者服藥前，服藥后0.5ｈ、1ｈ、2ｈ、4ｈ的疼痛緩解、疼痛消失患者比例，，及頭痛伴隨癥狀。 結(jié)果：歐立停5mg較治療急性期偏頭痛的常規(guī)藥物相比具有更好的療效。治療組患者在用藥后0.5ｈ、1ｈ、2ｈ、4ｈ的出現(xiàn)頭痛緩解分別為30.91%，58.18%，81.81%，94.54%，治療組服藥后4h內(nèi)出現(xiàn)疼痛緩解的患者比例較對照組高(P0.05)。治療組患者在用藥后0.5ｈ、1ｈ、2ｈ、4ｈ的頭痛消失患者比例分別為9.09%，25.45%，53.18%，74.54%，服藥后4h內(nèi)疼痛消失的患者比例較對照組高(P0.05)。經(jīng)4h治療后，兩組患者均為再出現(xiàn)嘔吐癥狀，惡心、畏光、聲也較治療前明顯減低，其中治療組的惡心癥狀明顯低于對照組（P0.05)。 結(jié)論：偏頭痛患者中卵圓孔未閉的發(fā)生率高，而卵圓孔未閉患者中偏頭痛發(fā)生率高；c-TCD診斷PFO的敏感性及特異性高；目前尚無充分的證據(jù)表明行PFO封堵術(shù)可以緩解偏頭痛發(fā)作，是否行封堵仍存在爭議；苯甲酸利扎曲普坦治療合并PFO的偏頭痛療效顯著。
[Abstract]:Objective: to evaluate the efficacy of rizatriptan benzoate in the treatment of migraine with patent foramen ovale. Participants and methods: 113 cases of migraine with positive foaming test were collected from May 2013 to December 2013 in Department of Neurology, Bai Qiuen first Hospital, Jilin University. There were 55 cases (15 males, 40 females, mean age 36.5 鹵11.14 years), 58 patients (16 males, 42 females) who took routine anti-migraine medication. The average age was 36. 2 鹵11. 11 years old. The patients in the treatment group were treated with oletazone 5 mg, the control group took 1 routine antimigraine drug at the beginning of the headache attack. The pain relief, pain disappearance rate and headache associated symptoms were observed at 0.5 h, 1 h and 2 h after the treatment. Results: olipid 5mg was more effective than conventional medicine in treating acute migraine. In the treatment group, the headache relief was 30.91g 58.18g and 81.81R 94.54mg, respectively. In the treatment group, pain relief occurred within 4 hours after taking medicine. The proportion of patients in the treatment group was higher than that in the control group (P 0.05). The proportion of headache disappeared in the treatment group was 9.09 ~ 25.45% and 53.18% respectively. The proportion of the pain disappeared within 4 hours after taking the drug was higher than that in the control group (P 0.05). After 4 hours of treatment, the proportion of the patients in the treatment group was higher than that in the control group (P 0.05). The symptoms of vomiting, nausea, photophobia and noise in both groups were significantly lower than those before treatment, and the nausea symptoms in the treatment group were significantly lower than those in the control group (P 0.05). Conclusion: the incidence of patent foramen ovale in patients with migraine is high, while the incidence of migraine in patients with patent foramen ovale is high. Whether or not to block is still controversial, and rizatriptan benzoate is effective in the treatment of migraine with PFO.
【學(xué)位授予單位】：吉林大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R747.2

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