本文選題：腦梗死/中西醫(yī)結(jié)合療法　切入點(diǎn)：溶栓時(shí)間窗外　出處：《中醫(yī)研究》2016年12期 　論文類型：期刊論文

【摘要】：目的:觀察金匱通脈方聯(lián)合阿替普酶溶栓治療對(duì)溶栓時(shí)間窗外急性腦梗死區(qū)域組織灌注的影響。方法:將50例溶栓時(shí)間窗外6~72 h急性腦梗死患者采用隨機(jī)數(shù)字表法隨機(jī)分為兩組,兩組均給予抗血小板、調(diào)脂、調(diào)控血壓和血糖等常規(guī)治療。對(duì)照組25例采用阿替普酶溶栓治療;治療組25例在對(duì)照組治療基礎(chǔ)上加服金匱通脈方(黃芪、全瓜蔞、薤白、益母草、丹參、山楂、制半夏),每日1劑,水煎服。兩組均治療14 d后判定療效。結(jié)果:兩組治療后腦梗死中心區(qū)域CBV、CBF均較治療前增加,MTT較治療前縮短,但治療組改善程度明顯優(yōu)于對(duì)照組(P0.01);治療組治療后腦梗死周圍區(qū)域CBV、CBF均較治療前增加(P0.01),且治療組改善程度明顯優(yōu)于對(duì)照組(P0.01);治療組治療后腦梗死中心和周圍區(qū)域的r CBV、r CBF均較治療前明顯增加(P0.01)。結(jié)論:金匱通脈方聯(lián)合阿替普酶溶栓治療溶栓時(shí)間窗外急性腦梗死能夠改善患者腦梗死中心及其周圍區(qū)域組織灌注,尤其對(duì)梗死周圍組織灌注的改善較為明顯,值得進(jìn)一步研究和運(yùn)用。
[Abstract]:Objective: to observe the effect of Jinkui Tongmai recipe combined with atropine enzyme thrombolytic therapy on tissue perfusion in acute cerebral infarction region outside thrombolytic time window. Methods: 50 patients with acute cerebral infarction outside the thrombolytic time window for 672 hours were treated with random digital table. Methods were randomly divided into two groups. Both groups were given routine treatment such as anti-platelet, regulating lipid, regulating blood pressure and blood sugar. 25 cases in the control group were treated with atropine enzyme thrombolytic therapy, and 25 cases in the treatment group were treated with Jinkui Tongmai recipe (Astragalus, Trichosanthes, macrostemon macrostemon) on the basis of the treatment of the control group. Herba Leonurus, Salvia miltiorrhiza, Hawthorn, Pinellia ternata, 1 dose per day, decoction of water were used to evaluate the curative effect of both groups after 14 days. Results: the CBV CBF in the central area of cerebral infarction after treatment in both groups was shorter than that before treatment, and the increase of MTT in the central area of cerebral infarction in both groups was shorter than that before treatment. However, the improvement of the treatment group was better than that of the control group (P 0.01), and the CBF of the treatment group was significantly higher than that of the control group (P 0.01), and the CBF of the treatment group was significantly better than that of the control group (P 0.01), and the center and surrounding area of the cerebral infarction after treatment in the treatment group were significantly better than those in the control group. Conclusion: Jinguitongmai decoction combined with atropine enzyme thrombolytic therapy for acute cerebral infarction outside the thrombolytic time window can improve the perfusion of cerebral infarction center and surrounding region in patients with acute cerebral infarction. Especially, the improvement of periinfarction tissue perfusion is obvious, which is worthy of further study and application.
【作者單位】： 駐馬店市中醫(yī)院;
【分類號(hào)】：R743.33
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本文編號(hào)：1562888