本文關(guān)鍵詞： 頸段頸動脈狹窄 頸動脈支架置入術(shù) 血流動力學(xué) 數(shù)值模擬 壁面剪切應(yīng)力　出處：《大連醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：通過患者的數(shù)字減影血管造影(Digital Subtraction Angiography,DSA)圖片數(shù)據(jù)，應(yīng)用計算機流體力學(xué)數(shù)值模擬方法建立特異性二維頸段頸動脈血流動力學(xué)模型，評估頸動脈支架置入術(shù)前與術(shù)后頸動脈狹窄段血流動力學(xué)的特征。 方法：經(jīng)DSA導(dǎo)出10名因頸段頸動脈狹窄行支架置入術(shù)前術(shù)后的原始圖像，利用Photoshop軟件截取狹窄段術(shù)前術(shù)后的輪廓；應(yīng)用Matlab軟件獲取狹窄段輪廓的二維坐標，再利用Gambit軟件重新形成狹窄段的外形，并進行二維網(wǎng)格劃分并設(shè)定邊界條件，最后應(yīng)用Fluent軟件進行血流動力學(xué)數(shù)值模擬計算，對比支架置入術(shù)前與術(shù)后壁面剪切應(yīng)力、壓力和血流速度等相關(guān)參數(shù)的變化。 結(jié)果：經(jīng)過數(shù)值模擬計算后得出：對比術(shù)前，術(shù)后狹窄段及狹窄段遠端的血流動力學(xué)指標有明顯的變化。平均術(shù)前狹窄段血流速度為7.83±5.00m/s，術(shù)后為2.18±0.66m/s，P0.05；平均術(shù)前狹窄段遠端血流速度為0.72±0.35m/s，術(shù)后為1.91±0.22m/s， P0.05；平均術(shù)前狹窄段壓力值為9008±2211.01Pa，術(shù)后為13460±1655.43Pa，P0.05；平均術(shù)前狹窄段遠端壓力值為3562±1536.18Pa，術(shù)后為11677±2524.57Pa，P0.05；平均術(shù)前狹窄段WSS為3.57±2.68Pa，術(shù)后為0.95±0.36Pa，，P0.05。 結(jié)論：狹窄率超過95%的頸動脈的特異性二維血流動力學(xué)數(shù)值模擬是可行的；數(shù)值模擬是評估CAS前、后血流動力學(xué)特征的較好方法；對比CAS術(shù)前，術(shù)后頸動脈狹窄段血流速度降低，狹窄段遠端血流速度升高，狹窄段壓力值升高、狹窄段遠端壓力值升高，狹窄段WSS降低。
[Abstract]:Objective: to establish a specific two-dimensional carotid artery hemodynamic model by using digital subtraction angiography (DSA) image data and computer fluid dynamics (CFD) numerical simulation. To evaluate the hemodynamic characteristics of carotid stenosis before and after carotid stenting. Methods: the original images of 10 patients with carotid artery stenosis before and after stenting were obtained by DSA. The contours of the stenosis segments were intercepted by Photoshop software, and the 2D coordinates of the stenotic segments were obtained by Matlab software. Gambit software was used to reconstruct the shape of the narrow segment, and two-dimensional mesh was used to set the boundary conditions. Finally, the hemodynamic numerical simulation was carried out with Fluent software, and the wall shear stress before and after stent implantation was compared. Changes of pressure and blood flow velocity. Results: after numerical simulation, it was concluded that, The mean blood flow velocity of stenosis segment was 7.83 鹵5.00 m / s before operation, 2.18 鹵0.66 m / s / s after operation, 0.72 鹵0.35 m / s before operation, 1.91 鹵0.22 m / s, P 0.05 before operation, and 2.18 鹵0.66 m / s / s after operation, respectively. The pressure value was 9008 鹵2211.01 Paa, 13460 鹵1655.43 Paa P0.05, the mean distal pressure of stenosis segment was 3562 鹵1536.18 Paa, postoperative 11677 鹵2524.57 PaP0.05, the mean preoperative stenosis segment WSS was 3.57 鹵2.68 Paa, and the postoperative mean stenosis segment was 0.95 鹵0.36PaP0.05. Conclusion: it is feasible to simulate the specific two-dimensional hemodynamics of carotid artery with stenosis rate of more than 95%. Numerical simulation is a good method to evaluate the hemodynamic characteristics before and after CAS. After operation, the blood flow velocity of carotid artery stenosis segment decreased, the distal end blood flow velocity of stenosis segment increased, the pressure value of stenosis segment increased, the distal pressure value of stenosis segment increased, and WSS of stenosis segment decreased.
【學(xué)位授予單位】：大連醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R653;R816.2

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