本文關鍵詞： 頸段頸動脈狹窄 頸動脈支架置入術 血流動力學 數(shù)值模擬 壁面剪切應力　出處：《大連醫(yī)科大學》2014年碩士論文　論文類型：學位論文

【摘要】：目的：通過患者的數(shù)字減影血管造影(Digital Subtraction Angiography,DSA)圖片數(shù)據(jù)，應用計算機流體力學數(shù)值模擬方法建立特異性二維頸段頸動脈血流動力學模型，評估頸動脈支架置入術前與術后頸動脈狹窄段血流動力學的特征。 方法：經(jīng)DSA導出10名因頸段頸動脈狹窄行支架置入術前術后的原始圖像，利用Photoshop軟件截取狹窄段術前術后的輪廓；應用Matlab軟件獲取狹窄段輪廓的二維坐標，再利用Gambit軟件重新形成狹窄段的外形，并進行二維網(wǎng)格劃分并設定邊界條件，最后應用Fluent軟件進行血流動力學數(shù)值模擬計算，對比支架置入術前與術后壁面剪切應力、壓力和血流速度等相關參數(shù)的變化。 結果：經(jīng)過數(shù)值模擬計算后得出：對比術前，術后狹窄段及狹窄段遠端的血流動力學指標有明顯的變化。平均術前狹窄段血流速度為7.83±5.00m/s，術后為2.18±0.66m/s，P0.05；平均術前狹窄段遠端血流速度為0.72±0.35m/s，術后為1.91±0.22m/s， P0.05；平均術前狹窄段壓力值為9008±2211.01Pa，術后為13460±1655.43Pa，P0.05；平均術前狹窄段遠端壓力值為3562±1536.18Pa，術后為11677±2524.57Pa，P0.05；平均術前狹窄段WSS為3.57±2.68Pa，術后為0.95±0.36Pa，，P0.05。 結論：狹窄率超過95%的頸動脈的特異性二維血流動力學數(shù)值模擬是可行的；數(shù)值模擬是評估CAS前、后血流動力學特征的較好方法；對比CAS術前，術后頸動脈狹窄段血流速度降低，狹窄段遠端血流速度升高，狹窄段壓力值升高、狹窄段遠端壓力值升高，狹窄段WSS降低。
[Abstract]:Objective: to establish a specific two-dimensional carotid artery hemodynamic model by using digital subtraction angiography (DSA) image data and computer fluid dynamics (CFD) numerical simulation. To evaluate the hemodynamic characteristics of carotid stenosis before and after carotid stenting. Methods: the original images of 10 patients with carotid artery stenosis before and after stenting were obtained by DSA. The contours of the stenosis segments were intercepted by Photoshop software, and the 2D coordinates of the stenotic segments were obtained by Matlab software. Gambit software was used to reconstruct the shape of the narrow segment, and two-dimensional mesh was used to set the boundary conditions. Finally, the hemodynamic numerical simulation was carried out with Fluent software, and the wall shear stress before and after stent implantation was compared. Changes of pressure and blood flow velocity. Results: after numerical simulation, it was concluded that, The mean blood flow velocity of stenosis segment was 7.83 鹵5.00 m / s before operation, 2.18 鹵0.66 m / s / s after operation, 0.72 鹵0.35 m / s before operation, 1.91 鹵0.22 m / s, P 0.05 before operation, and 2.18 鹵0.66 m / s / s after operation, respectively. The pressure value was 9008 鹵2211.01 Paa, 13460 鹵1655.43 Paa P0.05, the mean distal pressure of stenosis segment was 3562 鹵1536.18 Paa, postoperative 11677 鹵2524.57 PaP0.05, the mean preoperative stenosis segment WSS was 3.57 鹵2.68 Paa, and the postoperative mean stenosis segment was 0.95 鹵0.36PaP0.05. Conclusion: it is feasible to simulate the specific two-dimensional hemodynamics of carotid artery with stenosis rate of more than 95%. Numerical simulation is a good method to evaluate the hemodynamic characteristics before and after CAS. After operation, the blood flow velocity of carotid artery stenosis segment decreased, the distal end blood flow velocity of stenosis segment increased, the pressure value of stenosis segment increased, the distal pressure value of stenosis segment increased, and WSS of stenosis segment decreased.
【學位授予單位】：大連醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R653;R816.2

【參考文獻】

相關期刊論文 前6條

1 劉恒方;黃曉松;劉尊敬;楊期東;;頸動脈狹窄動物模型制作的研究進展[J];國際神經(jīng)病學神經(jīng)外科學雜志;2006年01期

2 沈珠軍;冠狀動脈球囊成形術及支架術后再狹窄[J];基礎醫(yī)學與臨床;2001年02期

3 劉有軍,喬愛科,主海文,高松;頸動脈分支的血流動力學數(shù)值模擬[J];計算力學學報;2004年04期

4 梁國光;血漿是非牛頓流體[J];西安醫(yī)科大學學報;1997年02期

5 符偉國;王利新;王玉琦;;顱外段頸動脈狹窄治療指南[J];中國實用外科雜志;2008年11期

6 王捷;楊宏;李淼;楊新健;徐忠信;;彈性壁兔頸動脈狹窄模型的建立及切應力數(shù)值模擬[J];中國實驗診斷學;2009年04期

本文編號：1550794