本文關(guān)鍵詞： 激光多普勒 興奮性氨基酸 腎上腺髓質(zhì)素 海人酸　出處：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的探討蛛網(wǎng)膜下腔出血后氧化應(yīng)激鏈中興奮性氨基酸對(duì)腦微循環(huán)的影響。方法頸內(nèi)血管穿刺法制作大鼠蛛網(wǎng)膜下腔出血模型。實(shí)驗(yàn)共分3組,出血模型3天組與急性期組(對(duì)照)。其中,出血后3天組又分2組,一組大鼠確定海馬CA3區(qū),另一組確定側(cè)腦室區(qū),分別采用微量進(jìn)樣器直接注射興奮性氨基酸類似物海人酸(KA)與腎上腺髓質(zhì)素(ADM),激光多普勒監(jiān)測(cè),觀察并對(duì)比三者腦表面局部血流灌注量的變化趨勢(shì)。結(jié)果ADM能提高SAH后腦表面局部微循環(huán)血流灌注量,KA能、降低其腦表面局部微循環(huán)血流灌注量。結(jié)論SAH后產(chǎn)生的氧化應(yīng)激鏈中興奮性氨基酸能夠顯著降低腦表面局部微循環(huán)血流灌注量。
[Abstract]:Objective to investigate the effect of excitatory amino acids in oxidative stress chain on cerebral microcirculation after subarachnoid hemorrhage. The hemorrhage model group was divided into two groups: one group determined the CA3 area of hippocampus, the other group determined the lateral ventricular area, 3 days after bleeding, the rats were divided into two groups. The model group was divided into two groups: one group was divided into two groups, one group was the hippocampus CA3 area, the other group was the lateral ventricle area. The excitatory amino acid analogue kainic acid (kainic acid) and adrenal medullin (ADMN) were injected directly into the microsampler and monitored by laser Doppler. Results ADM could increase the amount of blood perfusion of local microcirculation on the surface of brain after SAH. Conclusion the excitatory amino acids produced in oxidative stress chain after SAH can significantly decrease the amount of regional microcirculation perfusion on brain surface.
【作者單位】： 華北理工大學(xué)附屬醫(yī)院神經(jīng)外科;河北省遵化市人民醫(yī)院神經(jīng)外科;華北理工大學(xué)基礎(chǔ)醫(yī)學(xué)院(河北省慢性疾病重點(diǎn)實(shí)驗(yàn)室 唐山市慢性病臨床基礎(chǔ)研究重點(diǎn)實(shí)驗(yàn)室);
【基金】：河北省級(jí)重大醫(yī)學(xué)項(xiàng)目(No:Zd2013093)
【分類號(hào)】：R743.35

【參考文獻(xiàn)】

相關(guān)期刊論文 前1條

1 凌鵬;李月月;錢恒;連曉媛;;星形膠質(zhì)細(xì)胞對(duì)興奮性氨基酸神經(jīng)遞質(zhì)的調(diào)控及與癲癇的關(guān)系[J];神經(jīng)藥理學(xué)報(bào);2015年02期

【共引文獻(xiàn)】

相關(guān)期刊論文 前3條

1 高建亮;劉振剛;孫林林;付愛(ài)軍;李建民;^且，

本文編號(hào)：1539810