本文關(guān)鍵詞： 事件相關(guān)電位 外源性電位 聽刺激 成熟化　出處：《第三軍醫(yī)大學(xué)學(xué)報》2017年17期 　論文類型：期刊論文

【摘要】：目的遵循2009年國際事件相關(guān)電位(event-related potentials,ERPs)指南,獲取不同年齡組兒童聽覺ERPs外源性反應(yīng)電位主要波形潛伏期及波幅正常值,總結(jié)兒童聽覺ERPs外源性反應(yīng)電位發(fā)育規(guī)律和臨床應(yīng)用前景。方法收集2008-2010年156名兒童與成人(兒童來源于重慶醫(yī)科大學(xué)附屬兒童醫(yī)院兒童保健科門診,骨科、普外科、呼吸及消化科呼吸道感染及消化道感染恢復(fù)期的住院患兒,成人為重慶醫(yī)科大學(xué)健康在讀大學(xué)生),分為3~5、5~7、7~9歲和9~17歲組,以及22~29歲青年成人組。采用經(jīng)典的"Oddball"模式進行聽覺ERPs檢測,每名受試者均進行2次以上測試,以判斷波形的重復(fù)性。電位儀分別顯示靶刺激和非靶刺激下ERPs疊加后圖形,對ERPs各外源性成分P1、N1、P2和N2波形測量,包括波潛伏期及波幅。結(jié)果靶刺激或非靶刺激誘發(fā)的外源性電位潛伏期均隨年齡增長非勻速地成熟性縮短。無論靶刺激或非靶刺激,各年齡組的所有外源性電位波潛伏期均值中,95%以上都在2SD范圍內(nèi)。除N1波外,靶刺激下P1、P2、N2波幅隨年齡增加呈先增高后降低趨勢,成人和青少年期波幅反較兒童期低(P0.05)。非靶刺激下,95%的健康成人甚至不能引出N2波形。所有外源性電位波幅均值皆伴有較大標(biāo)準(zhǔn)差,提示存在明顯個體差異性。結(jié)論 ERPs外源性電位各波潛伏期同樣隨年齡規(guī)律性縮短,靶刺激較非靶刺激有更恒定的檢測結(jié)果,可直接反映顳葉初級聽覺皮層功能,且不受患者合作程度影響。
[Abstract]:Objective to obtain the normal amplitude and latency of auditory ERPs exogenous response potential in children of different ages according to the guidelines of international event-related potentials on 2009. Methods from 2008 to 2010, 156 children and adults (children from the Children's Health Department, Department of Children's Health, Department of Orthopaedics, General surgery Department of Chongqing Medical University) were collected. The hospitalized children with respiratory tract infection and digestive tract infection in the Department of Respiratory and Digestive Diseases were divided into 3 groups, aged 9 years old and 9 years old, who were enrolled in Chongqing Medical University. The auditory ERPs was detected by classical "Oddball" mode. Each subject was tested for more than two times to judge the repeatability of the waveform. The potentiometer showed the superposition pattern of ERPs under target and non-target stimuli, respectively. The wave latencies and amplitudes of P _ 1N _ 1N _ 2 and N _ 2 waveforms of various exogenous components of ERPs were measured. Results the latency of exogenous potentials induced by target or non-target stimuli decreased with age, regardless of target or non-target stimuli. More than 95% of the latency of all exogenous potential waves in all age groups were in the range of 2SD. With the exception of N1 wave, the amplitudes of P1P _ 2N _ 2 under target stimulation increased first and then decreased with the increase of age. The amplitude of wave in adults and adolescents was lower than that in children (P 0.05). 95% of healthy adults without target stimulation could not even elicit N2 waveforms. All the mean amplitude of exogenous potentials were accompanied by larger standard deviation. Conclusion the latencies of exogenous potentials of ERPs are also shortened with age, and the results of target stimulation are more constant than those of non-target stimuli, which can directly reflect the function of the primary auditory cortex in temporal lobe. And not affected by the degree of patient cooperation.
【作者單位】： 重慶醫(yī)科大學(xué)附屬兒童醫(yī)院神經(jīng)內(nèi)科;鄭州兒童醫(yī)院神經(jīng)內(nèi)科;
【基金】：重慶市自然科學(xué)基金(CSTC2009BB5274)~~
【分類號】：R741.044

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