發(fā)布時(shí)間：2018-02-13 05:42

  本文關(guān)鍵詞： 底丘腦核 帕金森病 腦深部電刺激 T2序列 腦老化　出處：《河北醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：利用3.0T MRI對底丘腦核進(jìn)行多序列及多方位掃描，尋找顯示底丘腦核的最佳掃描參數(shù)及掃描方位；評價(jià)正常腦老化過程中底丘腦核的形態(tài)變化，旨在探索底丘腦核的生理老化規(guī)律，為底丘腦核相關(guān)疾病的研究奠定基礎(chǔ)。 方法：首先選取3名健康右利手志愿者，男1名，，女2名，年齡20~79歲，行MRI T1、T2、FLAIR常規(guī)檢查，并采用T2-3D-DRIVE CLEAR、T2*、SWI序列分別進(jìn)行軸位、冠狀位及矢狀位三個(gè)方位的掃描，得出最佳掃描參數(shù)及掃描方位。選取134名健康右利手志愿者，男63名，女71名，年齡20~79歲，平均年齡49歲，中位年齡30歲，并按性別、年齡分組，進(jìn)行垂直于AC-PC線的T2-3D-DRIVE CLEAR冠狀位掃描，顯示出兩側(cè)核團(tuán)的最大截面，手工繪制感興趣區(qū)，測量兩側(cè)底丘腦核的最大長徑、短徑及最大截面積。應(yīng)用SPSS13.0軟件進(jìn)行統(tǒng)計(jì)分析。采用成組t檢驗(yàn)、配對t檢驗(yàn)等比較底丘腦核不同側(cè)別、性別、年齡組間各統(tǒng)計(jì)指標(biāo)的差異，探索底丘腦核的形態(tài)與年齡的相關(guān)關(guān)系。 結(jié)果： 1在應(yīng)用飛利浦公司Achieva3.0T超導(dǎo)磁共振設(shè)備條件下，經(jīng)過T1、FLAIR、SWI、T2*、T2幾種最常用且具有代表性的序列進(jìn)行篩選和對比觀察得出顯示底丘腦核的MRI最佳序列為T2，鑒于底丘腦核的解剖學(xué)特點(diǎn)，進(jìn)而選擇T2-3D-DRIVE CLEAR。 比較觀察包括軸位、矢狀位、冠狀位三個(gè)常用掃描方位對核團(tuán)的顯示情況，得出底丘腦核最理想的顯示方位為垂直于AC-PC線的冠狀位。 2對底丘腦核于垂直于AC-PC線的冠狀位最大截面形態(tài)進(jìn)行歸納總結(jié)，得出底丘腦核于冠狀位呈現(xiàn)三種形態(tài)類型：雙凸透鏡形、羊角形、柳葉形。 3底丘腦核冠狀位掃描所得兩側(cè)最大截面積、最大長徑及最大短徑三個(gè)結(jié)構(gòu)參數(shù)與性別、側(cè)別、不同年齡組、各組之間的統(tǒng)計(jì)學(xué)結(jié)果如下： 底丘腦核的冠狀位最大截面積、最大長徑及最大短徑男女之間均不存在差異（P0.05）。 底丘腦核的兩側(cè)冠狀位最大截面積、最大長徑及最大短徑均不存在側(cè)別差異(P0.05)。 底丘腦核的兩側(cè)冠狀位最大截面積、最大長徑及最大短徑不同年齡組間兩兩比較，得出結(jié)果為組間均無差異（P＞0.05） 結(jié)論： 1底丘腦核的MRI最佳掃描序列為T2序列；最理想的顯示方位為垂直于AC-PC線的冠狀位。 2底丘腦核于垂直于AC-PC線的冠狀位呈現(xiàn)三種形態(tài)類型：雙凸透鏡形、羊角形、柳葉形。 3底丘腦核冠狀位最大截面積、最大長徑及最大短徑值不存在性別差異；底丘腦核冠狀位最大截面積、最大長徑及最大短徑值不存在側(cè)別差異；底丘腦核的冠狀位最大截面積、最大長徑及最大短徑隨年齡的增長不發(fā)生變化。
[Abstract]:Objective: to evaluate the morphologic changes of subthalamic nucleus during normal brain aging by using 3.0T MRI to scan the subthalamic nucleus in order to find out the best scanning parameters and scanning orientation of the subthalamic nucleus. The purpose of this study was to explore the physiological aging law of subthalamic nucleus and to lay a foundation for the study of subthalamic nucleus-related diseases. Methods: three healthy right-handedness volunteers, one male and two female, aged 20 to 79 years old, were selected for routine MRI T1T2FLAIR examination. The axial, coronal and sagittal positions were scanned by T2-3D-DRIVE clear T2FLAIR sequence. The optimal scanning parameters and scanning orientation were obtained. 134 healthy right-handedness volunteers were selected, 63 males and 71 females, aged 2079 years, with an average age of 49 years, with a median age of 30 years, and were grouped according to sex and age. T2-3D-DRIVE CLEAR coronal scanning perpendicular to the AC-PC line showed the maximum cross-section of the bilateral nuclei, manually plotted the region of interest, and measured the maximum length and diameter of the bilateral subthalamic nuclei. Short diameter and maximum cross-sectional area were analyzed by SPSS13.0 software. The difference of statistical indexes among different sides, sex and age groups of subthalamic nucleus was compared by group t test and paired t test. To explore the correlation between the shape of subthalamic nucleus and age. Results:. 1 under the condition of Achieva3.0T superconducting magnetic resonance equipment of Philips Company, through screening and comparing several most commonly used and representative sequences of T _ (1) FLAIRI _ (SWI) T _ (2) T _ (2), it was found that the best sequence of MRI in the subthalamic nucleus was T _ (2), in view of the anatomical characteristics of the subthalamic nucleus. Then T2-3D-DRIVE clear. By comparing and observing the display of nuclei in axial, sagittal and coronal positions, it is concluded that the optimal display orientation of the subthalamic nucleus is perpendicular to the AC-PC line. 2 the maximum sectional shape of the subthalamic nucleus in the coronal position perpendicular to the AC-PC line was summarized, and three morphological types of the subthalamic nucleus in the coronal position were obtained: double convex lens, goat horn and willow leaf. 3The maximum cross sectional area, maximum length diameter and maximum short diameter of the subthalamic nucleus were obtained by coronal scanning of the subthalamic nucleus. The three structural parameters, sex, side and age group, were as follows:. There was no significant difference in coronal cross sectional area, maximum length diameter and maximum short diameter of subthalamic nucleus between male and female. The maximum coronal cross sectional area, the maximum length and the maximum short diameter of the subthalamic nucleus were not different from each other (P 0.05). The maximum coronal cross sectional area, maximum length diameter and maximum short diameter of subthalamic nucleus were compared between different age groups. The results showed that there was no difference between the two groups (P > 0.05). Conclusion:. 1the best scanning sequence of MRI in subthalamic nucleus was T2 sequence, and the optimal display orientation was coronal position perpendicular to AC-PC line. 2 the coronal position of the subthalamic nucleus perpendicular to the AC-PC line showed three morphological types: double convex lens, goat horn and willow leaf. (3) there was no gender difference in the maximum cross-sectional area, the maximum length and the maximum short diameter of the subthalamic nucleus, the maximum cross-sectional area, the maximum length and the maximum short diameter of the subthalamic nucleus were not different from those in the coronal position of the subthalamic nucleus, and the coronal maximum cross-sectional area of the subthalamic nucleus was not different from that of the subthalamic nucleus. The maximum length diameter and the maximum short diameter do not change with the increase of age.
【學(xué)位授予單位】：河北醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R445.2;R742.5

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