發(fā)布時(shí)間：2018-02-12 07:14

  本文關(guān)鍵詞： 血塞通膠囊 缺血性腦血管病 血液流變學(xué)　出處：《中國老年學(xué)雜志》2017年18期 　論文類型：期刊論文

【摘要】：目的探討血塞通膠囊對老年缺血性腦血管病(ICD)患者頸動(dòng)脈粥樣硬化軟斑塊及血液流變學(xué)的影響。方法老年ICD患者106例,采用隨機(jī)數(shù)字表法分為對照組(常規(guī)西藥治療)和觀察組(常規(guī)西藥治療的基礎(chǔ)上聯(lián)合血塞通膠囊治療)各53例。治療前及治療6個(gè)月后分別對兩組進(jìn)行彩超檢查、血脂檢查及血液流變學(xué)檢查。觀察并比較兩組治療過程中心血管事件的發(fā)生情況。結(jié)果治療6個(gè)月后兩組CAS軟斑塊的厚度、大小及頸動(dòng)脈內(nèi)膜中層厚度(IMT)均明顯下降,且觀察組低于對照組(P0.05)。治療前與治療6個(gè)月后,兩組甘油三酯(TG)、總膽固醇(TC)、低密度脂蛋白(LDL)水平均無統(tǒng)計(jì)學(xué)差異(P0.05),治療6個(gè)月后兩組均較治療前明顯降低(P0.05)。治療6個(gè)月后兩組全血粘度(低切變率、高切變率)、血漿黏度、網(wǎng)織紅細(xì)胞、血小板聚集率均明顯下降(P0.05),且觀察組明顯低于對照組(均P0.05)。觀察組心血管事件發(fā)生率明顯低于對照組(P0.05)。結(jié)論血塞通膠囊與常規(guī)西藥聯(lián)合治療老年ICD能有效改善患者的CAS軟斑塊和血液流變學(xué)指標(biāo),并具有較高的安全性。
[Abstract]:Objective to investigate the effect of Xuesaitong capsule on carotid atherosclerosis soft plaque and hemorheology in elderly patients with ischemic cerebrovascular disease. The patients were randomly divided into control group (conventional western medicine treatment) and observation group (53 cases treated with Xuesaitong capsule on the basis of routine western medicine treatment). The two groups were examined by color Doppler ultrasonography before and after 6 months of treatment. After 6 months of treatment, the thickness, size and intima-media thickness of CAS in the two groups were significantly decreased. And the observation group was lower than the control group (P 0.05). There was no significant difference in the levels of TGG, TC, LDL between the two groups. After 6 months of treatment, the whole blood viscosity (low shear rate, high shear rate, plasma viscosity) of the two groups was significantly lower than that of the pre-treatment group (low shear rate, high shear rate, plasma viscosity). Reticulocyte, The platelet aggregation rate decreased significantly in both groups, and the incidence of cardiovascular events in the observation group was significantly lower than that in the control group (P 0.05). Conclusion Xuesaitong capsule combined with conventional western medicine can effectively improve the incidence of ICD in the elderly. CAS soft plaque and hemorheology, And has high safety.
【作者單位】： 鄭州大學(xué)第五附屬醫(yī)院神經(jīng)內(nèi)五科;
【分類號】：R743.3

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